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Gene Review

PGD1  -  Pgd1p

Saccharomyces cerevisiae S288c

Synonyms: HRS1, Hyper-recombination suppressor protein 1, MED3, Mediator complex subunit 3, Mediator of RNA polymerase II transcription subunit 3, ...
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Disease relevance of PGD1

  • We have purified a His(6) tagged version of Hrs1p protein from E. coli and have obtained specific anti-Hrs1p polyclonal antibodies [1].

High impact information on PGD1

  • Hence, the Gal11p/Med2p/Pgd1p triad may contribute to TBP recruitment independently of the rest of mediator [2].
  • Thus, the Gal11p/Med2p/Pgd1p triad is both necessary for recruitment of intact mediator and appears to be sufficient for recruitment by Gcn4p as a free subcomplex [2].
  • Second, mutation of pgd1 causes partial disruption of the Sin4 complex and leads to a defect in transcription reinitiation [3].
  • Hrs1p/Mcp6p on the meiotic SPB organizes astral microtubule arrays for oscillatory nuclear movement [4].
  • Hrs1p interacted with components of the gamma-tubulin ring complex (gamma-TuRC) as well as with a meiotic SPB component [4].

Biological context of PGD1

  • We provide genetic evidence that HRS1/PGD1, a yeast gene previously identified as a suppressor of the hyper-recombination phenotype of hpr1, has positive and negative roles in transcriptional regulation [5].
  • Our results suggest that Hrs1p is required for the formation of deletions between direct repeats and that it may function in gene expression [1].
  • We have cloned, sequenced and deleted from the genome the HRS1 gene [1].
  • In addition, Hrs1p was required for mating-factor expression, telomere-linked DNA silencing and DNA supercoiling of plasmids [5].
  • The DNA sequence of the HRS1 gene reveals that it is identical to PGD1, a gene with no reported function, and that the Hrs1p protein contains polyglutamine stretches typically found in transcription factors [1].

Anatomical context of PGD1

  • Furthermore, hrs1 delta cells show reduced induction of the GAL1,10 promoter relative to wild-type cells [1].

Associations of PGD1 with chemical compounds

  • The yeast HRS1 gene encodes a polyglutamine-rich nuclear protein required for spontaneous and hpr1-induced deletions between direct repeats [1].
  • Finally, artificial holoenzyme recruitment assays support a model by which the contact between the corepressor and the Hrs1/Mediator may prevent pol II holoenzyme recruitment to the core promoter [6].
  • Two-hybrid and glutathione S-transferase interaction assays show that Hrs1 can associate directly with Cyc8-Tup1 [6].

Regulatory relationships of PGD1

  • RESULTS: Fusions with Med2 or Pgd1 activated CUP1 independently of TFIIE [7].

Other interactions of PGD1

  • The hrs1 delta null mutation reduces the frequency of deletions in wild-type and hpr1 delta backgrounds sevenfold below wild-type and rad52 levels [1].

Analytical, diagnostic and therapeutic context of PGD1


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