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Gene Review

MNN10  -  Mnn10p

Saccharomyces cerevisiae S288c

Synonyms: BED1, Bud emergence delay protein 1, M-Pol II subunit MNN10, Mannan polymerase II complex MNN10 subunit, REC41, ...
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High impact information on MNN10

  • During a screen based on the inability of cells impaired in the budding process to survive when the morphogenesis checkpoint control is abolished, we identified and characterized BED1, a new gene that is required for efficient budding [1].
  • Our results suggest that Bed1 is a type II membrane protein localized in the endoplasmic reticulum [1].
  • BED1 is significantly homologous to gma12+, a S. pombe gene coding for an alpha-1,2,-galactosyltransferase, suggesting that glycosylation of specific proteins or lipids could be important for signaling in the switch to polarized growth and in bud emergence [1].
  • Thus, double mutants of SED1 and either MNN9 or MNN10 were unable to grow and YOL155c on a multicopy plasmid could suppress their synthetic lethality [2].
  • The expression of the HO gene does not lead to inviability of rec41 cells [3].

Biological context of MNN10


Other interactions of MNN10

  • Diploid strains homozygous for the rec41 rad52 mutations had the same gamma-ray sensitivity as single rad52 diploids and exhibited dramatically decreased growth rate [3].
  • The genes MNN10 and MNN11 of Saccharomyces cerevisiae encode mannosyltransferases responsible for the majority of the alpha-1,6-polymerizing activity of the mannosyltransferase complex [4].

Analytical, diagnostic and therapeutic context of MNN10


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