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Gene Review:

MNN9 - mannosyltransferase complex subunit MNN9

Saccharomyces cerevisiae S288c

Synonyms: M-Pol II subunit MNN9, M-pol I subunit MNN9, Mannan polymerase complexes subunit MNN9, P7102.01, YPL050C

Southard, S.B. et al., Osmond, B.C. et al., Horie, T. et al., Kim, S.Y. et al.

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High impact information on MNN9

In addition to finding, not surprisingly, that mutations in major cell wall-related genes such as FKS1 (glucan synthase) and mutations in any of the Golgi glycosylation complex genes (MNN9 family) are lethal in combination with chs3Delta, we found that a mutation in Srv2p, a bifunctional regulatory gene, is notably lethal in the chs3 deletion [1].
Here we describe the molecular analysis of the Candida albicans homolog of Saccharomyces cerevisiae MNN9, a gene required for the synthesis of N-linked outer-chain mannan in yeast, and the phenotypes associated with its disruption [2].
Molecular analysis of the Candida albicans homolog of Saccharomyces cerevisiae MNN9, required for glycosylation of cell wall mannoproteins [2].
Like all members of the S. cerevisiae MNN9 gene family the Camnn9Delta strain is resistant to sodium orthovanadate and sensitive to hygromycin B [2].
Our results suggest that, while the role MNN9 plays in glycosylation in both Candida and Saccharomyces is conserved, loss of MNN9 function in C. albicans leads to phenotypes that are inconsistent with the pathogenicity of the organism and thus identify CaMnn9p as a potential drug target [2].

Biological context of MNN9

Thus, double mutants of SED1 and either MNN9 or MNN10 were unable to grow and YOL155c on a multicopy plasmid could suppress their synthetic lethality [3].
This gene was cloned from a H. polymorpha genomic DNA library using the S. cerevisiae MNN9 gene as a probe [4].

References

Chitin synthase III: synthetic lethal mutants and "stress related" chitin synthesis that bypasses the CSD3/CHS6 localization pathway. Osmond, B.C., Specht, C.A., Robbins, P.W. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
Molecular analysis of the Candida albicans homolog of Saccharomyces cerevisiae MNN9, required for glycosylation of cell wall mannoproteins. Southard, S.B., Specht, C.A., Mishra, C., Chen-Weiner, J., Robbins, P.W. J. Bacteriol. (1999) [Pubmed]
Cooperative functions of the mannoprotein-encoding genes in the biogenesis and maintenance of the cell wall in Saccharomyces cerevisiae. Horie, T., Isono, K. Yeast (2001) [Pubmed]
Cloning and characterization of the Hansenula polymorpha homologue of the Saccharomyces cerevisiae MNN9 gene. Kim, S.Y., Sohn, J.H., Kang, H.A., Yoo, S.K., Pyun, Y.R., Choi, E.S. Yeast (2001) [Pubmed]

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AGOS_AGL259C	Ashbya gossypii ATCC 10895
KLLA0E12849g	Kluyveromyces lactis NRRL Y-1140
MGG_00171	Magnaporthe oryzae 70-15
NCU02635	Neurospora crassa OR74A
mnn9	Schizosaccharomyces pombe 972h-

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