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Gene Review:

SAP4 - Sap4p

Saccharomyces cerevisiae S288c

Synonyms: SIT4-associating protein SAP4, YGL229C

Taylor, B.N. et al., Borg-von Zepelin, M. et al., Sanglard, D. et al., Schaller, M. et al., Luke, M.M. et al., et al.

Sanglard, Hube, Monod, Odds, Gow,

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Disease relevance of SAP4

These findings point to a link between morphogenetic development and expression of virulence genes during Candida vaginitis in mice, where host signals induce both hyphal formation and expression of SAP4 and SAP5, but temporal gene expression patterns are ultimately controlled by other factors [1].

High impact information on SAP4

By sequence homology, we isolated two additional SAP genes, SAP185 and SAP4 [2].
These results support a role for Sap4 to Sap6 in pathogenicity [3].
The expression of the secreted aspartyl proteinases Sap4 to Sap6 from Candida albicans in murine macrophages [3].
Using these antisera, together with sap null mutants obtained by targeted mutagenesis, we could demonstrate a high production of Sap4, Sap5 and Sap6 by C. albicans cells after phagocytosis by murine peritoneal macrophages [3].
Of the six SAP genes that were analyzed (SAP1 to SAP6), only SAP4 and SAP5 were detectably induced during infection in this model [1].

Biological context of SAP4

Two other homologs, SAP4 and SAP190, are without effect on K+ homeostasis [4].
A triple deletion of the secreted aspartyl proteinase genes SAP4, SAP5, and SAP6 of Candida albicans causes attenuated virulence [5].

Analytical, diagnostic and therapeutic context of SAP4

SAP2 and SAP8 RT-PCR products were first detected 60 h after infection, while SAP4 and SAP5 transcripts were never discovered [6].

References

Profile of Candida albicans-secreted aspartic proteinase elicited during vaginal infection. Taylor, B.N., Staib, P., Binder, A., Biesemeier, A., Sehnal, M., Röllinghoff, M., Morschhäuser, J., Schröppel, K. Infect. Immun. (2005) [Pubmed]
The SAP, a new family of proteins, associate and function positively with the SIT4 phosphatase. Luke, M.M., Della Seta, F., Di Como, C.J., Sugimoto, H., Kobayashi, R., Arndt, K.T. Mol. Cell. Biol. (1996) [Pubmed]
The expression of the secreted aspartyl proteinases Sap4 to Sap6 from Candida albicans in murine macrophages. Borg-von Zepelin, M., Beggah, S., Boggian, K., Sanglard, D., Monod, M. Mol. Microbiol. (1998) [Pubmed]
Ability of Sit4p to promote K+ efflux via Nha1p is modulated by Sap155p and Sap185p. Manlandro, C.M., Haydon, D.H., Rosenwald, A.G. Eukaryotic Cell (2005) [Pubmed]
A triple deletion of the secreted aspartyl proteinase genes SAP4, SAP5, and SAP6 of Candida albicans causes attenuated virulence. Sanglard, D., Hube, B., Monod, M., Odds, F.C., Gow, N.A. Infect. Immun. (1997) [Pubmed]
Differential expression of secreted aspartyl proteinases in a model of human oral candidosis and in patient samples from the oral cavity. Schaller, M., Schäfer, W., Korting, H.C., Hube, B. Mol. Microbiol. (1998) [Pubmed]

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