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Gene Review

MND1  -  Mnd1p

Saccharomyces cerevisiae S288c

Synonyms: G1604, Meiotic nuclear division protein 1, YGL183C
 
 
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High impact information on MND1

 

Biological context of MND1

  • We used a functional genomics approach to identify a gene required for meiotic recombination, YGL183c or MND1 [5].
  • CONCLUSION: We conclude that AtMND1 is required for homologous pairing and is likely to play a role in the repair of DNA double strand breaks during meiosis in Arabidopsis, thus showing conservation of function with that of MND1 during meiosis in yeast [6].
  • The mnd1-null mutant arrests in meiotic prophase, with most double-strand breaks (DSBs) unrepaired [7].
  • The Arabidopsis thaliana MND1 homologue plays a key role in meiotic homologous pairing, synapsis and recombination [8].
  • Localization studies suggest that Mnd1 carries out this function without being specifically recruited to the sites of DNA repair [9].
 

Anatomical context of MND1

  • Although the rna mutants do not regulate ribosome synthesis during sporulation, all of these diploid strains fail to complete sporulation at 34 degrees C. The cells are arrested after the second meiotic nuclear division but before ascus formation [10].
 

Associations of MND1 with chemical compounds

 

Physical interactions of MND1

  • In Saccharomyces cerevisiae, the Hop2 protein forms a complex with the Mnd1 protein and is required for the alignment of homologous chromosomes during meiosis, probably through extensive homology matching between them [12].
 

Regulatory relationships of MND1

 

Other interactions of MND1

References

  1. Segregation of recombined chromosomes in meiosis I requires DNA topoisomerase II. Rose, D., Thomas, W., Holm, C. Cell (1990) [Pubmed]
  2. Gametogenesis in yeast is regulated by a transcriptional cascade dependent on Ndt80. Chu, S., Herskowitz, I. Mol. Cell (1998) [Pubmed]
  3. The pachytene checkpoint. Roeder, G.S., Bailis, J.M. Trends Genet. (2000) [Pubmed]
  4. Heterodimeric complexes of Hop2 and Mnd1 function with Dmc1 to promote meiotic homolog juxtaposition and strand assimilation. Chen, Y.K., Leng, C.H., Olivares, H., Lee, M.H., Chang, Y.C., Kung, W.M., Ti, S.C., Lo, Y.H., Wang, A.H., Chang, C.S., Bishop, D.K., Hsueh, Y.P., Wang, T.F. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  5. Mnd1p: an evolutionarily conserved protein required for meiotic recombination. Gerton, J.L., DeRisi, J.L. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  6. AtMND1 is required for homologous pairing during meiosis in Arabidopsis. Panoli, A.P., Ravi, M., Sebastian, J., Nishal, B., Reddy, T.V., Marimuthu, M.P., Subbiah, V., Vijaybhaskar, V., Siddiqi, I. BMC Mol. Biol. (2006) [Pubmed]
  7. The Mnd1 protein forms a complex with hop2 to promote homologous chromosome pairing and meiotic double-strand break repair. Tsubouchi, H., Roeder, G.S. Mol. Cell. Biol. (2002) [Pubmed]
  8. The Arabidopsis thaliana MND1 homologue plays a key role in meiotic homologous pairing, synapsis and recombination. Kerzendorfer, C., Vignard, J., Pedrosa-Harand, A., Siwiec, T., Akimcheva, S., Jolivet, S., Sablowski, R., Armstrong, S., Schweizer, D., Mercier, R., Schlögelhofer, P. J. Cell. Sci. (2006) [Pubmed]
  9. Mnd1 is required for meiotic interhomolog repair. Zierhut, C., Berlinger, M., Rupp, C., Shinohara, A., Klein, F. Curr. Biol. (2004) [Pubmed]
  10. Changes in regulation of ribosome synthesis during different stages of the life cycle of Saccharomyces cerevisiae. Pearson, N.J., Haber, J.E. Mol. Gen. Genet. (1977) [Pubmed]
  11. Inhibiton by sulfanilamide of sporulation in Saccharomyces cerevisiae. Colonna, W.J., Gentile, J.M., Magee, P.T. Can. J. Microbiol. (1977) [Pubmed]
  12. Stimulation of DNA strand exchange by the human TBPIP/Hop2-Mnd1 complex. Enomoto, R., Kinebuchi, T., Sato, M., Yagi, H., Kurumizaka, H., Yokoyama, S. J. Biol. Chem. (2006) [Pubmed]
  13. SPO13 negatively regulates the progression of mitotic and meiotic nuclear division in Saccharomyces cerevisiae. McCarroll, R.M., Esposito, R.E. Genetics (1994) [Pubmed]
  14. Analysis of close stable homolog juxtaposition during meiosis in mutants of Saccharomyces cerevisiae. Lui, D.Y., Peoples-Holst, T.L., Mell, J.C., Wu, H.Y., Dean, E.W., Burgess, S.M. Genetics (2006) [Pubmed]
  15. Expression and nuclear localization of BLM, a chromosome stability protein mutated in Bloom's syndrome, suggest a role in recombination during meiotic prophase. Moens, P.B., Freire, R., Tarsounas, M., Spyropoulos, B., Jackson, S.P. J. Cell. Sci. (2000) [Pubmed]
  16. Genetic and biochemical characterization of the yeast spo12 protein. Grether, M.E., Herskowitz, I. Mol. Biol. Cell (1999) [Pubmed]
 
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