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UGA1  -  4-aminobutyrate transaminase

Saccharomyces cerevisiae S288c

Synonyms: 4-aminobutyrate aminotransferase, GABA aminotransferase, GABA transaminase, GABA-AT, Gamma-amino-N-butyrate transaminase, ...
 
 
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High impact information on UGA1

 

Biological context of UGA1

  • Analysis of the 5' region of the UGA1 and UGA4 genes led to the identification of a conserved GC-rich sequence (UASGABA) essential to induction by gamma-aminobutyrate [3].
  • While the ugatA gene under the control of the A. nidulans gatA promoter was able to fully complement a gatA- phenotype in A. nidulans, the full-length ugatA gene was not, suggesting a lack of expression from the U. maydis promoter in A. nidulans [6].
  • It is likely that upon duplication approximately 200 million years ago, a specialized Uga1p evolved into a 'novel' transaminase enzyme with broader substrate specificity [7].
 

Associations of UGA1 with chemical compounds

  • The fact that L-norleucine-leucine aminotransferase, 4-aminobutyrate aminotransferase and delta-aminovalerate aminotransferase are strongly induced by growing the yeast Candida on L-lysine suggests new hypothetic pathways for the catabolism of L-lysine where the main substrate of each aminotransferase could be an intermediary metabolite [8].
 

Other interactions of UGA1

  • Some of them simultaneously control the expression of the UGA1 and UGA2 genes [9].
  • Measurements of UGA1-specific transcripts show that induction of UGA1 correlates with accumulation of its RNA and requires a functional UGA3 gene [10].

References

  1. Expression of the DAL80 gene, whose product is homologous to the GATA factors and is a negative regulator of multiple nitrogen catabolic genes in Saccharomyces cerevisiae, is sensitive to nitrogen catabolite repression. Cunningham, T.S., Cooper, T.G. Mol. Cell. Biol. (1991) [Pubmed]
  2. The DAL81 gene product is required for induced expression of two differently regulated nitrogen catabolic genes in Saccharomyces cerevisiae. Bricmont, P.A., Daugherty, J.R., Cooper, T.G. Mol. Cell. Biol. (1991) [Pubmed]
  3. Cis- and trans-acting elements determining induction of the genes of the gamma-aminobutyrate (GABA) utilization pathway in Saccharomyces cerevisiae. Talibi, D., Grenson, M., André, B. Nucleic Acids Res. (1995) [Pubmed]
  4. Nucleotide sequence of the yeast UGA1 gene encoding GABA transaminase. André, B., Jauniaux, J.C. Nucleic Acids Res. (1990) [Pubmed]
  5. Regulatory circuit for responses of nitrogen catabolic gene expression to the GLN3 and DAL80 proteins and nitrogen catabolite repression in Saccharomyces cerevisiae. Daugherty, J.R., Rai, R., el Berry, H.M., Cooper, T.G. J. Bacteriol. (1993) [Pubmed]
  6. Characterization of the ugatA gene of Ustilago maydis, isolated by homology to the gatA gene of Aspergillus nidulans. Straffon, M.J., Hynes, M.J., Davis, M.A. Curr. Genet. (1996) [Pubmed]
  7. A gene duplication led to specialized gamma-aminobutyrate and beta-alanine aminotransferase in yeast. Andersen, G., Andersen, B., Dobritzsch, D., Schnackerz, K.D., Piskur, J. FEBS J. (2007) [Pubmed]
  8. Lysine degradation in Candida. Characterization and probable role of L-norleucine-leucine, 4-aminobutyrate and delta-aminovalerate:2-oxoglutarate aminotransferases. Der Garabedian, P.A., Vermeersch, J.J. Biochimie (1989) [Pubmed]
  9. Positive and negative regulatory elements control the expression of the UGA4 gene coding for the inducible 4-aminobutyric-acid-specific permease in Saccharomyces cerevisiae. Vissers, S., Andre, B., Muyldermans, F., Grenson, M. Eur. J. Biochem. (1989) [Pubmed]
  10. The UGA3 gene regulating the GABA catabolic pathway in Saccharomyces cerevisiae codes for a putative zinc-finger protein acting on RNA amount. André, B. Mol. Gen. Genet. (1990) [Pubmed]
 
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