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Gene Review

HOC1  -  Hoc1p

Saccharomyces cerevisiae S288c

Synonyms: J1830, M-Pol II subunit Hoc1p, Mannan polymerase II complex HOC1 subunit, YJR075W
 
 
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Disease relevance of HOC1

 

High impact information on HOC1

  • Functional characterization of the Hansenula polymorpha HOC1, OCH1, and OCR1 genes as members of the yeast OCH1 mannosyltransferase family involved in protein glycosylation [2].
  • Analysis of interactions between the proteins in this complex shows that Mnn10p, and four previously characterized proteins (Anp1p, Mnn9p, Mnn11p, and Hoc1p) are indeed all components of the same large structure [3].
  • Saccharomyces cerevisiae HOC1, a suppressor of pkc1, encodes a putative glycosyltransferase [1].
  • While overexpression of HOC1 rescued the pkc1-371 temperature-sensitive cell lysis phenotype, disruption of HOC1 lowered the restrictive temperature of the pkc1-371 allele [1].
  • Taken together, these results suggest that HOC1 encodes a Golgi-localized putative mannosyltransferase required for the proper construction of the cell wall [1].
 

Biological context of HOC1

  • Here we describe the characterization of HOC1, a gene identified by its ability to suppress the cell lysis phenotype of pkc1-371 cells [1].
 

Anatomical context of HOC1

 

Associations of HOC1 with chemical compounds

  • When solubilized by Triton X-100, it was recovered in two distinct complexes both having mannosyltransferase activity; one with Van1 protein (V-complex) and the other with Anp1, Hoc1, Mnn10, and Mnn11 proteins (A-complex) [4].
 

Other interactions of HOC1

  • The HOC1 gene (Homologous to OCH1) is predicted to encode a type II integral membrane protein that strongly resembles Och 1p, an alpha-1,6-mannosyltransferase [1].

References

  1. Saccharomyces cerevisiae HOC1, a suppressor of pkc1, encodes a putative glycosyltransferase. Neiman, A.M., Mhaiskar, V., Manus, V., Galibert, F., Dean, N. Genetics (1997) [Pubmed]
  2. Functional characterization of the Hansenula polymorpha HOC1, OCH1, and OCR1 genes as members of the yeast OCH1 mannosyltransferase family involved in protein glycosylation. Kim, M.W., Kim, E.J., Kim, J.Y., Park, J.S., Oh, D.B., Shimma, Y., Chiba, Y., Jigami, Y., Rhee, S.K., Kang, H.A. J. Biol. Chem. (2006) [Pubmed]
  3. The Saccharomyces cerevisiae protein Mnn10p/Bed1p is a subunit of a Golgi mannosyltransferase complex. Jungmann, J., Rayner, J.C., Munro, S. J. Biol. Chem. (1999) [Pubmed]
  4. Interaction among the subunits of Golgi membrane mannosyltransferase complexes of the yeast Saccharomyces cerevisiae. Kojima, H., Hashimoto, H., Yoda, K. Biosci. Biotechnol. Biochem. (1999) [Pubmed]
 
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