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Gene Review

CCNB3  -  cyclin B3

Homo sapiens

Synonyms: CYCB3, G2/mitotic-specific cyclin-B3
 
 
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High impact information on CCNB3

 

Biological context of CCNB3

  • This may suggest a dominant-negative function of human cyclin B3 in competition with activating cyclins in G(0) and the G(1) phase of the cell cycle [3].
  • In order to determine whether downregulation of cyclin B3 at zygotene-pachytene transition was important for normal spermatogenesis, we investigated the consequences of expressing H. sapiens cyclin B3 after zygotene in mouse testes [4].
 

Physical interactions of CCNB3

  • It had been shown that cyclin B3 coimmunoprecipitates with cdk2; but this complex does not exhibit any kinase activity [3].
 

Analytical, diagnostic and therapeutic context of CCNB3

References

  1. The cloning of cyclin B3 and its gene expression during hormonally induced spermatogenesis in the teleost, Anguilla japonica. Kajiura-Kobayashi, H., Kobayashi, T., Nagahama, Y. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  2. Molecular cloning, gene localization, and structure of human cyclin B3. Lozano, J.C., Perret, E., Schatt, P., Arnould, C., Peaucellier, G., Picard, A. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  3. Human cyclin B3. Tschöp, K., Müller, G.A., Grosche, J., Engeland, K. FEBS J. (2006) [Pubmed]
  4. Misexpression of cyclin B3 leads to aberrant spermatogenesis. Refik-Rogers, J., Manova, K., Koff, A. Cell Cycle (2006) [Pubmed]
 
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