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Gene Review

CKA2  -  casein kinase 2 catalytic subunit CKA2

Saccharomyces cerevisiae S288c

Synonyms: CK II, Casein kinase II subunit alpha', YOR061W, YOR29-12
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High impact information on CKA2

  • The alpha' subunit encoded by the CKA2 gene is 60% identical to the CKA1-encoded alpha subunit and 55% identical to the Drosophila alpha subunit (A. Saxena, R. Padmanabha, and C. V. C. Glover, Mol. Cell. Biol. 7:3409-3417, 1987) [1].
  • Null mutations in the CKA1 gene do not confer a detectable phenotype (J. L.-P. Chen-Wu, R. Padmanabha, and C. V. C. Glover, Mol. Cell. Biol. 8:4981-4990, 1988), presumably because of the presence of the CKA2 gene [1].
  • Haploid cells in which the CKA2 gene alone is disrupted show no detectable phenotype, but haploid cells carrying disruptions in both the CKA1 and CKA2 genes are inviable [1].
  • We report here the identification of CDC37, which encodes a putative Hsp90 co-chaperone, as a multicopy suppressor of a temperature-sensitive allele (cka2-13(ts)) of the CKA2 gene encoding the alpha' catalytic subunit of protein kinase CKII [2].
  • Five independent temperature-sensitive alleles of the CKA2 gene were isolated and used to analyze the function of CKII during the cell cycle [3].

Biological context of CKA2


Anatomical context of CKA2

  • The cka2 mutants, on the other hand, exhibited only 25 to 30% of the in vitro CS activity found in wild-type membranes, indicating that the alpha' subunit of CK2 kinase is necessary for full activation of CS [6].

Associations of CKA2 with chemical compounds


Other interactions of CKA2

  • In addition, a mutation in CRZ1, which specifies a homologue of the Saccharomyces cerevisiae transcription factor that is a major target of calcineurin, suppresses fluconazole resistance of cka2 mutants [4].
  • We suggest that a Cka2p-dependent regulatory pathway is altered by clinically derived azole resistance mutations [4].
  • Two of them correspond to CK-II and the other three have been called RAP-1, RAP-II, and RAP-III [8].


  1. Isolation, sequencing, and disruption of the yeast CKA2 gene: casein kinase II is essential for viability in Saccharomyces cerevisiae. Padmanabha, R., Chen-Wu, J.L., Hanna, D.E., Glover, C.V. Mol. Cell. Biol. (1990) [Pubmed]
  2. A positive feedback loop between protein kinase CKII and Cdc37 promotes the activity of multiple protein kinases. Bandhakavi, S., McCann, R.O., Hanna, D.E., Glover, C.V. J. Biol. Chem. (2003) [Pubmed]
  3. Casein kinase II is required for cell cycle progression during G1 and G2/M in Saccharomyces cerevisiae. Hanna, D.E., Rethinaswamy, A., Glover, C.V. J. Biol. Chem. (1995) [Pubmed]
  4. Regulation of azole drug susceptibility by Candida albicans protein kinase CK2. Bruno, V.M., Mitchell, A.P. Mol. Microbiol. (2005) [Pubmed]
  5. Halogenated benzimidazole inhibitors of phosphorylation, in vitro and in vivo, of the surface acidic proteins of the yeast ribosomal 60S subunit by endogenous protein kinases CK-II and PK60S. Szyszka, R., Boguszewska, A., Shugar, D., Grankowski, N. Acta Biochim. Pol. (1996) [Pubmed]
  6. Ceramide/long-chain base phosphate rheostat in Saccharomyces cerevisiae: regulation of ceramide synthesis by Elo3p and Cka2p. Kobayashi, S.D., Nagiec, M.M. Eukaryotic Cell (2003) [Pubmed]
  7. Genetic interactions among ZDS1,2, CDC37, and protein kinase CK2 in Saccharomyces cerevisiae. Bandhakavi, S., McCann, R.O., Hanna, D.E., Glover, C.V. FEBS Lett. (2003) [Pubmed]
  8. Ribosomal stalk protein phosphorylating activities in Saccharomyces cerevisiae. Bou, G., Remacha, M., Ballesta, J.P. Arch. Biochem. Biophys. (2000) [Pubmed]
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