Gene Review:
CSNK2A1 - casein kinase 2, alpha 1 polypeptide
Homo sapiens
Synonyms:
CK II alpha, CK2A1, CKII, CSNK2A3, Casein kinase II subunit alpha
- Recombinant human casein kinase II. A study with the complete set of subunits (alpha, alpha' and beta), site-directed autophosphorylation mutants and a bicistronically expressed holoenzyme. Bodenbach, L., Fauss, J., Robitzki, A., Krehan, A., Lorenz, P., Lozeman, F.J., Pyerin, W. Eur. J. Biochem. (1994)
- Casein kinase II phosphorylation increases the rate of serum response factor-binding site exchange. Marais, R.M., Hsuan, J.J., McGuigan, C., Wynne, J., Treisman, R. EMBO J. (1992)
- Casein kinase II phosphorylates I kappa B alpha at S-283, S-289, S-293, and T-291 and is required for its degradation. McElhinny, J.A., Trushin, S.A., Bren, G.D., Chester, N., Paya, C.V. Mol. Cell. Biol. (1996)
- Casein kinase II alpha subunit and C1-inhibitor are independent predictors of outcome in patients with squamous cell carcinoma of the lung. O-charoenrat, P., Rusch, V., Talbot, S.G., Sarkaria, I., Viale, A., Socci, N., Ngai, I., Rao, P., Singh, B. Clin. Cancer Res. (2004)
- The MYCN protein of human neuroblastoma cells is phosphorylated by casein kinase II in the central region and at serine 367. Hamann, U., Wenzel, A., Frank, R., Schwab, M. Oncogene (1991)
- Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity. Ayer, D.E., Kretzner, L., Eisenman, R.N. Cell (1993)
- Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity. Lin, A., Frost, J., Deng, T., Smeal, T., al-Alawi, N., Kikkawa, U., Hunter, T., Brenner, D., Karin, M. Cell (1992)
- Casein kinase II enhances the DNA binding activity of serum response factor. Manak, J.R., de Bisschop, N., Kris, R.M., Prywes, R. Genes Dev. (1990)
- Activation of skeletal muscle casein kinase II by insulin is not diminished in subjects with insulin resistance. Maeda, R., Raz, I., Zurlo, F., Sommercorn, J. J. Clin. Invest. (1991)
- Regulation of endosome sorting by a specific PP2A isoform. Molloy, S.S., Thomas, L., Kamibayashi, C., Mumby, M.C., Thomas, G. J. Cell Biol. (1998)
- Casein kinase II is a selective target of HIV-1 transcriptional inhibitors. Critchfield, J.W., Coligan, J.E., Folks, T.M., Butera, S.T. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Assembly of hepatitis delta virus particles: package of multimeric hepatitis delta virus genomic RNA and role of phosphorylation. Yeh, T.S., Lee, Y.H. Virology (1998)
- Genomic organization and promoter identification of the human protein kinase CK2 catalytic subunit alpha (CSNK2A1). Wirkner, U., Voss, H., Ansorge, W., Pyerin, W. Genomics (1998)
- Phosphorylation of vitronectin by casein kinase II. Identification of the sites and their promotion of cell adhesion and spreading. Seger, D., Gechtman, Z., Shaltiel, S. J. Biol. Chem. (1998)
- Phosphorylation of threonine 10 on CKBBP1/SAG/ROC2/Rbx2 by protein kinase CKII promotes the degradation of IkappaBalpha and p27Kip1. Kim, Y.S., Lee, J.Y., Son, M.Y., Park, W., Bae, Y.S. J. Biol. Chem. (2003)
- Phosphorylation of the DNA repair protein APE/REF-1 by CKII affects redox regulation of AP-1. Fritz, G., Kaina, B. Oncogene (1999)
- The human gene (CSNK2A1) coding for the casein kinase II subunit alpha is located on chromosome 20 and contains tandemly arranged Alu repeats. Wirkner, U., Voss, H., Lichter, P., Ansorge, W., Pyerin, W. Genomics (1994)
- Casein kinase II-mediated phosphorylation regulates alpha-synuclein/synphilin-1 interaction and inclusion body formation. Lee, G., Tanaka, M., Park, K., Lee, S.S., Kim, Y.M., Junn, E., Lee, S.H., Mouradian, M.M. J. Biol. Chem. (2004)
- Casein kinase II phosphorylates the neural cell adhesion molecule L1. Wong, E.V., Schaefer, A.W., Landreth, G., Lemmon, V. J. Neurochem. (1996)
- Human-immunodeficiency-virus-type-1-encoded Vpu protein is phosphorylated by casein kinase II. Schubert, U., Schneider, T., Henklein, P., Hoffmann, K., Berthold, E., Hauser, H., Pauli, G., Porstmann, T. Eur. J. Biochem. (1992)
- The DNA-binding and transcriptional activities of MAZ, a myc-associated zinc finger protein, are regulated by casein kinase II. Tsutsui, H., Geltinger, C., Murata, T., Itakura, K., Wada, T., Handa, H., Yokoyama, K.K. Biochem. Biophys. Res. Commun. (1999)
- Identification and partial characterization of factor Va heavy chain kinase from human platelets. Kalafatis, M. J. Biol. Chem. (1998)
- Casein kinase II interacts with the bZIP domains of several transcription factors. Yamaguchi, Y., Wada, T., Suzuki, F., Takagi, T., Hasegawa, J., Handa, H. Nucleic Acids Res. (1998)
- Molecular dissection of nucleolin's role in growth and cell proliferation: new insights. Srivastava, M., Pollard, H.B. FASEB J. (1999)
- The highly basic ribosomal protein L41 interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase IIalpha by CKII. Lee, J.H., Kim, J.M., Kim, M.S., Lee, Y.T., Marshak, D.R., Bae, Y.S. Biochem. Biophys. Res. Commun. (1997)
- Interaction between casein kinase II and the 90-kDa stress protein, HSP90. Miyata, Y., Yahara, I. Biochemistry (1995)
- Copurification of casein kinase II with transcription factor ATF/E4TF3. Wada, T., Takagi, T., Yamaguchi, Y., Kawase, H., Hiramoto, M., Ferdous, A., Takayama, M., Lee, K.A., Hurst, H.C., Handa, H. Nucleic Acids Res. (1996)
- Phosphorylation of the oncogenic transcription factor interferon regulatory factor 2 (IRF2) in vitro and in vivo. Birnbaum, M.J., van Zundert, B., Vaughan, P.S., Whitmarsh, A.J., van Wijnen, A.J., Davis, R.J., Stein, G.S., Stein, J.L. J. Cell. Biochem. (1997)
- Specific phosphorylation of the acidic central region of the N-myc protein by casein kinase II. Hagiwara, T., Nakaya, K., Nakamura, Y., Nakajima, H., Nishimura, S., Taya, Y. Eur. J. Biochem. (1992)
- Serine 32 and serine 36 of IkappaBalpha are directly phosphorylated by protein kinase CKII in vitro. Taylor, J.A., Bren, G.D., Pennington, K.N., Trushin, S.A., Asin, S., Paya, C.V. J. Mol. Biol. (1999)
- Purification and characterization of echinoderm casein kinase II. Regulation by protein kinase C. Sanghera, J.S., Charlton, L.A., Paddon, H.B., Pelech, S.L. Biochem. J. (1992)
- Differential phosphorylations of Spi-B and Spi-1 transcription factors. Mao, C., Ray-Gallet, D., Tavitian, A., Moreau-Gachelin, F. Oncogene (1996)
- Human CD5 signaling and constitutive phosphorylation of C-terminal serine residues by casein kinase II. Calvo, J., Vildà, J.M., Places, L., Simarro, M., Padilla, O., Andreu, D., Campbell, K.S., Aussel, C., Lozano, F. J. Immunol. (1998)
- A structural model for elongation factor 1 (EF-1) and phosphorylation by protein kinase CKII. Sheu, G.T., Traugh, J.A. Mol. Cell. Biochem. (1999)
- Growth-dependent modulation of casein kinase II and its substrate nucleolin in primary human cell cultures and HeLa cells. Schneider, H.R., Issinger, O.G. Biochim. Biophys. Acta (1989)