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Gene Review

RRD1  -  peptidylprolyl isomerase RRD1

Saccharomyces cerevisiae S288c

Synonyms: NCS1, PPIase PTPA-1, Peptidyl-prolyl cis-trans isomerase PTPA-1, Phosphotyrosyl phosphatase activator 1, Rotamase PTPA-1, ...
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High impact information on RRD1

  • To understand the molecular mechanism of PTPA activity, Ypa1 was cocrystallized with a proline-containing PPIase peptide substrate [1].
  • Strains lacking both NCS1 and NOH1 were inviable and arrested as unbudded cells, implying that PTPA function is required for proper G(1) progression [2].
  • The phosphotyrosyl phosphatase activator, Ncs1p (Rrd1p), functions with Cla4p to regulate the G(2)/M transition in Saccharomyces cerevisiae [2].
  • Genetic and biochemical evidence suggested that the phosphatase Sit4p is a target for Ncs1p [2].
  • The point mutant Asp205 --> Gly (in Ypa1) identified this amino acid as essential for both activities [3].

Biological context of RRD1


Anatomical context of RRD1


Associations of RRD1 with chemical compounds


Regulatory relationships of RRD1

  • Strikingly, the interaction of Ypa2 with yeast PP2A is promoted by the presence of Ypa1, suggesting a positive role of Ypa1 in the regulation of PP2A association with other interacting proteins [11].

Other interactions of RRD1

  • While deletion of both YPA genes is lethal, deletion of YPA1 alone results in a phenotype resembling that of PP2A-deficient strains in specific aspects such as aberrant bud morphology, abnormal actin distribution, and similar growth defects under various growth conditions [12].


  1. Crystal structure of the PP2A phosphatase activator: implications for its PP2A-specific PPIase activity. Leulliot, N., Vicentini, G., Jordens, J., Quevillon-Cheruel, S., Schiltz, M., Barford, D., van Tilbeurgh, H., Goris, J. Mol. Cell (2006) [Pubmed]
  2. The phosphotyrosyl phosphatase activator, Ncs1p (Rrd1p), functions with Cla4p to regulate the G(2)/M transition in Saccharomyces cerevisiae. Mitchell, D.A., Sprague, G.F. Mol. Cell. Biol. (2001) [Pubmed]
  3. The protein phosphatase 2A phosphatase activator is a novel peptidyl-prolyl cis/trans-isomerase. Jordens, J., Janssens, V., Longin, S., Stevens, I., Martens, E., Bultynck, G., Engelborghs, Y., Lescrinier, E., Waelkens, E., Goris, J., Van Hoof, C. J. Biol. Chem. (2006) [Pubmed]
  4. The Saccharomyces cerevisiae phosphatase activator RRD1 is required to modulate gene expression in response to rapamycin exposure. Douville, J., David, J., Lemieux, K.M., Gaudreau, L., Ramotar, D. Genetics (2006) [Pubmed]
  5. Functional analysis of RRD1 (YIL153w) and RRD2 (YPL152w), which encode two putative activators of the phosphotyrosyl phosphatase activity of PP2A in Saccharomyces cerevisiae. Rempola, B., Kaniak, A., Migdalski, A., Rytka, J., Slonimski, P.P., di Rago, J.P. Mol. Gen. Genet. (2000) [Pubmed]
  6. The Saccharomyces cerevisiae homologue YPA1 of the mammalian phosphotyrosyl phosphatase activator of protein phosphatase 2A controls progression through the G1 phase of the yeast cell cycle. Van Hoof, C., Janssens, V., De Baere, I., de Winde, J.H., Winderickx, J., Dumortier, F., Thevelein, J.M., Merlevede, W., Goris, J. J. Mol. Biol. (2000) [Pubmed]
  7. A yeast homologue of the human phosphotyrosyl phosphatase activator PTPA is implicated in protection against oxidative DNA damage induced by the model carcinogen 4-nitroquinoline 1-oxide. Ramotar, D., Belanger, E., Brodeur, I., Masson, J.Y., Drobetsky, E.A. J. Biol. Chem. (1998) [Pubmed]
  8. Neuronal calcium sensor-1: a multifunctional regulator of secretion. Hilfiker, S. Biochem. Soc. Trans. (2003) [Pubmed]
  9. The phosphotyrosyl phosphatase activator of protein phosphatase 2A. A novel purification method, immunological and enzymic characterization. Van Hoof, C., Cayla, X., Bosch, M., Merlevede, W., Goris, J. Eur. J. Biochem. (1994) [Pubmed]
  10. The yeast phosphotyrosyl phosphatase activator protein, yPtpa1/Rrd1, interacts with Sit4 phosphatase to mediate resistance to 4-nitroquinoline-1-oxide and UVA. Douville, J., David, J., Fortier, P.K., Ramotar, D. Curr. Genet. (2004) [Pubmed]
  11. Specific interactions of PP2A and PP2A-like phosphatases with the yeast PTPA homologues, Ypa1 and Ypa2. Van Hoof, C., Martens, E., Longin, S., Jordens, J., Stevens, I., Janssens, V., Goris, J. Biochem. J. (2005) [Pubmed]
  12. The Saccharomyces cerevisiae phosphotyrosyl phosphatase activator proteins are required for a subset of the functions disrupted by protein phosphatase 2A mutations. Van Hoof, C., Janssens, V., De Baere, I., Stark, M.J., de Winde, J.H., Winderickx, J., Thevelein, J.M., Merlevede, W., Goris, J. Exp. Cell Res. (2001) [Pubmed]
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