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Chemical Compound Review

RMH-79     5-nitrosoquinolin-8-ol

Synonyms: Hydron III, NSC-3852, ACMC-1CKMR, NCIMech_000145, AG-F-23634, ...
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Disease relevance of 4-Nitroquinoline-1-oxide


Psychiatry related information on 4-Nitroquinoline-1-oxide

  • In rats in which the application of 4NQO was discontinued earlier, the application period appeared to be in inverse proportion to the latency period i.e., the period between the last application of the carcinogen and the first clinical sign of squamous cell carcinoma [6].

High impact information on 4-Nitroquinoline-1-oxide


Chemical compound and disease context of 4-Nitroquinoline-1-oxide


Biological context of 4-Nitroquinoline-1-oxide

  • Transfer of this chromosome to XP-F cells restores approximately 20% of the resistance of wild-type cells to killing by UV radiation or by the UV-mimetic chemical 4-nitroquinoline-1-oxide (4NQO), as well as partial repair synthesis of DNA measured as unscheduled DNA synthesis [16].
  • RAD4 is not an essential gene, and no increased transcription of this gene is observed in cells exposed to the DNA-damaging agent 4-nitroquinoline-1-oxide [17].
  • Although the ddr48 mutant showed a slightly altered sensitivity to killing by 4-nitroquinoline-1-oxide and to heat shock compared with the DDR48 haploid, the spontaneous mutation rate of reversion of a his4 mutation was reduced 6- to 14-fold in the ddr48 strain [18].
  • In addition, the CSB mutant alleles were tested for their ability to complement the sensitivity of UV61 cells to the carcinogen 4-nitroquinoline-1-oxide (4-NQO), which introduces bulky DNA adducts repaired by global genome repair [19].
  • Similar ouar mutation frequencies were recorded in the two cell lines after 4-nitroquinoline-1-oxide (4NQO) treatment showing that the differences in cytotoxicity and mutagenesis are restricted to treatment with alkylating agents [20].

Anatomical context of 4-Nitroquinoline-1-oxide


Associations of 4-Nitroquinoline-1-oxide with other chemical compounds


Gene context of 4-Nitroquinoline-1-oxide


Analytical, diagnostic and therapeutic context of 4-Nitroquinoline-1-oxide


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  2. Effects in rats of sodium chloride on experimental gastric cancers induced by N-methyl-N-nitro-N-nitrosoguanidine or 4-nitroquinoline-1-oxide. Tatematsu, M., Takahashi, M., Fukushima, S., Hananouchi, M., Shirai, T. J. Natl. Cancer Inst. (1975) [Pubmed]
  3. RAD3 gene of Saccharomyces cerevisiae: nucleotide sequence of wild-type and mutant alleles, transcript mapping, and aspects of gene regulation. Naumovski, L., Chu, G., Berg, P., Friedberg, E.C. Mol. Cell. Biol. (1985) [Pubmed]
  4. Harvey ras (H-ras) point mutations are induced by 4-nitroquinoline-1-oxide in murine oral squamous epithelia, while squamous cell carcinomas and loss of heterozygosity occur without additional exposure. Yuan, B., Heniford, B.W., Ackermann, D.M., Hawkins, B.L., Hendler, F.J. Cancer Res. (1994) [Pubmed]
  5. Failure to complement abnormal phenotypes of simian virus 40-transformed Werner syndrome cells by introduction of a normal human chromosome 8. Kodama, S., Kashino, G., Suzuki, K., Takatsuji, T., Okumura, Y., Oshimura, M., Watanabe, M., Barrett, J.C. Cancer Res. (1998) [Pubmed]
  6. Epithelial dysplasia and squamous cell carcinoma of the Wistar rat palatal mucosa: 4NQO model. Nauta, J.M., Roodenburg, J.L., Nikkels, P.G., Witjes, M.J., Vermey, A. Head & neck. (1996) [Pubmed]
  7. Carcinogenicity of betel quid. III. Enhancement of 4-nitroquinoline-1-oxide- and N-2-fluorenylacetamide-induced carcinogenesis in rats by subsequent administration of betel nut. Tanaka, T., Kuniyasu, T., Shima, H., Sugie, S., Mori, H., Takahashi, M., Hirono, I. J. Natl. Cancer Inst. (1986) [Pubmed]
  8. Transformation and neoplastic development of hamster chondrocytes after exposure to 4-nitroquinoline-1-oxide and 3-methylcholanthrene in tissue culture. Katoh, Y. J. Natl. Cancer Inst. (1977) [Pubmed]
  9. Reduced DNA repair during differentiation of a myogenic cell line. Chan, A.C., Walker, I.G. J. Cell Biol. (1976) [Pubmed]
  10. RAD9-dependent G1 arrest defines a second checkpoint for damaged DNA in the cell cycle of Saccharomyces cerevisiae. Siede, W., Friedberg, A.S., Friedberg, E.C. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  11. Differentiation-inducing quinolines as experimental breast cancer agents in the MCF-7 human breast cancer cell model. Martirosyan, A.R., Rahim-Bata, R., Freeman, A.B., Clarke, C.D., Howard, R.L., Strobl, J.S. Biochem. Pharmacol. (2004) [Pubmed]
  12. Spontaneous and clastogen induced chromosomal breakage in scleroderma. Wolff, D.J., Needleman, B.W., Wasserman, S.S., Schwartz, S. J. Rheumatol. (1991) [Pubmed]
  13. Cytogenetical characterization of UV-sensitive repair-deficient CHO cell line 43-3B. II. Induction of cell killing, chromosomal aberrations and sister-chromatid exchanges by 4NQO, mono- and bi-functional alkylating agents. Darroudi, F., Natarajan, A.T., Lohman, P.H. Mutat. Res. (1989) [Pubmed]
  14. Sodium arsenite inhibits spontaneous and induced mutations in Escherichia coli. Nunoshiba, T., Nishioka, H. Mutat. Res. (1987) [Pubmed]
  15. A method to distinguish between the de novo induction of thymidine kinase mutants and the selection of pre-existing thymidine kinase mutants in the mouse lymphoma assay. Wang, J., Heflich, R.H., Moore, M.M. Mutat. Res. (2007) [Pubmed]
  16. Human chromosome 15 confers partial complementation of phenotypes to xeroderma pigmentosum group F cells. Saxon, P.J., Schultz, R.A., Stanbridge, E.J., Friedberg, E.C. Am. J. Hum. Genet. (1989) [Pubmed]
  17. RAD4 gene of Saccharomyces cerevisiae: molecular cloning and partial characterization of a gene that is inactivated in Escherichia coli. Fleer, R., Nicolet, C.M., Pure, G.A., Friedberg, E.C. Mol. Cell. Biol. (1987) [Pubmed]
  18. Structure of the DNA damage-inducible gene DDR48 and evidence for its role in mutagenesis in Saccharomyces cerevisiae. Treger, J.M., McEntee, K. Mol. Cell. Biol. (1990) [Pubmed]
  19. The ATPase domain but not the acidic region of Cockayne syndrome group B gene product is essential for DNA repair. Brosh, R.M., Balajee, A.S., Selzer, R.R., Sunesen, M., Proietti De Santis, L., Bohr, V.A. Mol. Biol. Cell (1999) [Pubmed]
  20. Cytotoxicity, mutations and SCEs induced by methylating agents are reduced in CHO cells expressing an active mammalian O6-methylguanine-DNA methyltransferase gene. Bignami, M., Terlizzese, M., Zijno, A., Calcagnile, A., Frosina, G., Abbondandolo, A., Dogliotti, E. Carcinogenesis (1987) [Pubmed]
  21. Loss of DNA repair capacity during successive subcultures of primary rat fibroblasts. Chan, A.C., Walker, I.G. J. Cell Biol. (1977) [Pubmed]
  22. Partial inhibition of postreplication repair and enhanced frequency of chemical transformation in rat cells infected with leukemia virus. Waters, R., Mishra, N., Bouck, N., DiMayorca, G., Regan, J.D. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
  23. A region within murine chromosome 7F4, syntenic to the human 11q13 amplicon, is frequently amplified in 4NQO-induced oral cavity tumors. Yuan, B., Oechsli, M.N., Hendler, F.J. Oncogene (1997) [Pubmed]
  24. Candida albicans as a promoter of oral mucosal neoplasia. O'Grady, J.F., Reade, P.C. Carcinogenesis (1992) [Pubmed]
  25. Expression of the yeast UB14 gene increases in response to DNA-damaging agents and in meiosis. Treger, J.M., Heichman, K.A., McEntee, K. Mol. Cell. Biol. (1988) [Pubmed]
  26. Mutagen sensitivity has high heritability: evidence from a twin study. Wu, X., Spitz, M.R., Amos, C.I., Lin, J., Shao, L., Gu, J., de Andrade, M., Benowitz, N.L., Shields, P.G., Swan, G.E. Cancer Res. (2006) [Pubmed]
  27. Multicell spheroid response to drugs predicted with the comet assay. Olive, P.L., Banáth, J.P. Cancer Res. (1997) [Pubmed]
  28. N-ras mutation in ultraviolet radiation-induced murine skin cancers. Pierceall, W.E., Kripke, M.L., Ananthaswamy, H.N. Cancer Res. (1992) [Pubmed]
  29. Increased expression of cyclooxygenase-2 protein in 4-nitroquinoline-1-oxide-induced rat tongue carcinomas and chemopreventive efficacy of a specific inhibitor, nimesulide. Shiotani, H., Denda, A., Yamamoto, K., Kitayama, W., Endoh, T., Sasaki, Y., Tsutsumi, N., Sugimura, M., Konishi, Y. Cancer Res. (2001) [Pubmed]
  30. Rsp5 ubiquitin-protein ligase mediates DNA damage-induced degradation of the large subunit of RNA polymerase II in Saccharomyces cerevisiae. Beaudenon, S.L., Huacani, M.R., Wang, G., McDonnell, D.P., Huibregtse, J.M. Mol. Cell. Biol. (1999) [Pubmed]
  31. Actions of a Histone Deacetylase Inhibitor NSC3852 (5-Nitroso-8-quinolinol) Link Reactive Oxygen Species to Cell Differentiation and Apoptosis in MCF-7 Human Mammary Tumor Cells. Martirosyan, A., Leonard, S., Shi, X., Griffith, B., Gannett, P., Strobl, J. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  32. DNA damage activates transcription and transposition of yeast Ty retrotransposons. Bradshaw, V.A., McEntee, K. Mol. Gen. Genet. (1989) [Pubmed]
  33. The yeast phosphotyrosyl phosphatase activator protein, yPtpa1/Rrd1, interacts with Sit4 phosphatase to mediate resistance to 4-nitroquinoline-1-oxide and UVA. Douville, J., David, J., Fortier, P.K., Ramotar, D. Curr. Genet. (2004) [Pubmed]
  34. Specific transcripts are elevated in Saccharomyces cerevisiae in response to DNA damage. McClanahan, T., McEntee, K. Mol. Cell. Biol. (1984) [Pubmed]
  35. DNA microfiltration assay: a simple technique for detecting DNA damage in mammalian cells. Leanderson, P., Wennerberg, K., Tagesson, C. Carcinogenesis (1994) [Pubmed]
  36. Absence of DNA repair deficiency in the confirmed heterozygotes of xeroderma pigmentosum group A. Moriwaki, S., Nishigori, C., Teramoto, T., Tanaka, T., Kore-eda, S., Takebe, H., Imamura, S. J. Invest. Dermatol. (1993) [Pubmed]
  37. The repair of large DNA adducts in mammalian cells. Waters, R., Jones, C.J., Martin, E.A., Yang, A.L., Jones, N.J. Mutat. Res. (1992) [Pubmed]
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