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Gene Review

DOT5  -  Dot5p

Saccharomyces cerevisiae S288c

Synonyms: Disrupter of telomere silencing protein 5, Nuclear thiol peroxidase, Peroxiredoxin DOT5, Thioredoxin reductase, YIL010W, ...
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Disease relevance of DOT5

  • A double mutant (C107S/C112S) of nTPx overexpressed in Escherichia coli was spontaneously degraded upon freezing and thawing and its truncated form (residues 57-215; MW = 17837 Da) was crystallized with PEG 3350 and mercury(II) acetate as precipitants using the hanging-drop vapour-diffusion method [1].
  • Hemolysate thioredoxin reductase and glutathione peroxidase activities correlate with serum selenium in a group of New Zealand men at high prostate cancer risk [2].

High impact information on DOT5


Other interactions of DOT5

  • Furthermore, Dot5 does not affect redox regulation of the Yap1 transcription factor [5].


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