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FUS2  -  Fus2p

Saccharomyces cerevisiae S288c

Synonyms: Nuclear fusion protein FUS2, YM9959.14, YMR232W
 
 
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High impact information on FUS2

  • We found that polarisome components and the cell fusion proteins Fus1 and Fus2 are important for the termination of projection growth [1].
  • Based on double mutant analysis, AXL1 in a MATalpha strain acted genetically in the same pathway with FUS2, a fusion-dedicated gene [2].
  • Rvs161p interacts with Fus2p to promote cell fusion in Saccharomyces cerevisiae [3].
  • FUS2 encodes a unique open reading frame of 617 residues that only is expressed in haploid cells in response to mating pheromone [4].
  • These, and other results suggest that Fus2 defines a novel cell fusion function and subcellular structure that is also required for the alignment of parental nuclei before nuclear fusion [4].
 

Biological context of FUS2

 

Anatomical context of FUS2

  • Consistent with a role in cell fusion, Fus2 protein localizes with discrete structures that could be of cytoskeletal or vesicular origin that accumulate at the tip of pheromone-induced shmoos and at the junction of paired cells in zygotes [4].
  • Fus2 is predicted to be a coiled-coil protein and fractionates with a 100,000 g pellet, suggesting that it is associated with cytoskeleton, membranes, or other macromolecular structures [4].
 

Other interactions of FUS2

  • In contrast, Fus2p and Rvs161p appeared to act after vesicle positioning [7].
  • In addition, we found that the defect in default mating caused by mutations in SPA2 is partially suppressed by multiple copies of two genes, FUS2 and MFA2 [8].
  • We characterized two genes, FUS1 and FUS2, which are required for fusion of Saccharomyces cerevisiae cells during conjugation [9].

References

  1. Regulation of polarized growth initiation and termination cycles by the polarisome and Cdc42 regulators. Bidlingmaier, S., Snyder, M. J. Cell Biol. (2004) [Pubmed]
  2. A role for a protease in morphogenic responses during yeast cell fusion. Elia, L., Marsh, L. J. Cell Biol. (1998) [Pubmed]
  3. Rvs161p interacts with Fus2p to promote cell fusion in Saccharomyces cerevisiae. Brizzio, V., Gammie, A.E., Rose, M.D. J. Cell Biol. (1998) [Pubmed]
  4. Fus2 localizes near the site of cell fusion and is required for both cell fusion and nuclear alignment during zygote formation. Elion, E.A., Trueheart, J., Fink, G.R. J. Cell Biol. (1995) [Pubmed]
  5. Extracting protein alignment models from the sequence database. Neuwald, A.F., Liu, J.S., Lipman, D.J., Lawrence, C.E. Nucleic Acids Res. (1997) [Pubmed]
  6. A novel link between a rab GTPase and Rvs proteins: the yeast amphiphysin homologues. Talarek, N., Balguerie, A., Aigle, M., Durrens, P. Cell Biochem. Funct. (2005) [Pubmed]
  7. Distinct morphological phenotypes of cell fusion mutants. Gammie, A.E., Brizzio, V., Rose, M.D. Mol. Biol. Cell (1998) [Pubmed]
  8. Genetic analysis of default mating behavior in Saccharomyces cerevisiae. Dorer, R., Boone, C., Kimbrough, T., Kim, J., Hartwell, L.H. Genetics (1997) [Pubmed]
  9. Two genes required for cell fusion during yeast conjugation: evidence for a pheromone-induced surface protein. Trueheart, J., Boeke, J.D., Fink, G.R. Mol. Cell. Biol. (1987) [Pubmed]
 
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