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Gene Review

SLC30A1  -  solute carrier family 30 (zinc...

Homo sapiens

Synonyms: Solute carrier family 30 member 1, ZNT1, ZRC1, Zinc transporter 1, ZnT-1
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Disease relevance of SLC30A1


Psychiatry related information on SLC30A1

  • Alterations in zinc transporter protein-1 (ZnT-1) in the brain of subjects with mild cognitive impairment, early, and late-stage Alzheimer's disease [4].

High impact information on SLC30A1


Chemical compound and disease context of SLC30A1

  • ZnT-1 reduces intracellular zinc accumulation and confers resistance against cadmium toxicity by a mechanism which is still unresolved [2].
  • Taken together, our results indicate that endogenously-expressed ZnT-1, by modulating LTCC, has a dual role: regulating calcium influx, and attenuating Cd(2+) and Zn(2+) permeation and toxicity in neurons and other cell types [2].

Biological context of SLC30A1

  • Furthermore, ZnT-1 may play a role in cellular ion homeostasis and thereby confer protection against pathophysiological events linked to cellular Ca(2+) or Zn(2+) permeation and cell death [7].
  • Differential regulation of zinc efflux transporters ZnT-1, ZnT-5 and ZnT-7 gene expression by zinc levels: a real-time RT-PCR study [8].
  • Complementation of a yeast Zn transport-defective mutant with a T. caerulescens cDNA library resulted in the recovery of a cDNA, ZNT1, that encodes a Zn transporter [9].
  • Moreover in HepG2 cells, immunochemical and fluorescence techniques showed the presence and the localisation of the zinc membrane exporter ZnT-1 as a further mechanism of defence/homeostasis against zinc toxicity [10].
  • Downregulation of ZnT-1 mRNA and partial loss of loosely bound Zn were observed with 50muM Cd [11].

Anatomical context of SLC30A1

  • In enterocytes of the small intestine and renal tubular cells, ZnT-1 is localized to the basolateral membrane, suggesting an orientation that is consistent with zinc absorption/retention [12].
  • Immunolocalization places ZnT-1 at the basolateral membrane of intestinal enterocytes and epithelial cells of the distal renal tubules [1].
  • In the whole pancreas of 3-day-old rats, ZnT-1 was the only zinc transporter mRNA detected and its level was moderate [13].
  • To evaluate the potential applications of using both zinc transporter genes as biomarkers of zinc status, we measured the expression levels of ZIP1 and ZNT1 in the peripheral leukocytes collected from 2 different age groups of Korean women [14].
  • In the human placental cell line JAR, however, expression at the mRNA level of a number of Zn transporters is not modified by Zn availability, whilst ZnT1 and hZTL1/ZnT5 proteins are reduced under Zn-supplemented conditions [15].

Associations of SLC30A1 with chemical compounds


Regulatory relationships of SLC30A1

  • Zinc has been shown to modify specifically the metabolism of cGMP, the activities of protein kinase C and mitogen activated protein kinases, and the activity of transcription factor MTF-1 which controls the transcription of the genes for metallothionein and the zinc transporter ZnT-1 [17].

Other interactions of SLC30A1

  • These findings suggest that factors such as ZnT1 and metallothioneins other than ZnT3 are associated with the low intracellular zinc content in AIDL cells [18].
  • Different induction of metallothioneins and Hsp70 and presence of the membrane transporter ZnT-1 in HepG2 cells exposed to copper and zinc [10].

Analytical, diagnostic and therapeutic context of SLC30A1

  • Western blot and dot-blot analysis showed statistically significant (p 0.05) elevations of ZnT-1 in AD AMY, HPG, and IPL and significantly depleted ZnT-1 in AD SMTG compared to age-matched control subjects [4].
  • Likely candidates include two proteins identified by molecular cloning termed zinc transporter 1 and divalent cation transporter DCT1 [19].
  • Sequence analysis of ZNT1 indicated it is a member of a recently discovered micronutrient transport gene family which includes the Arabidopsis Fe transporter, IRT1, and the ZIP Zn transporters [9].
  • Using real-time quantitative PCR, we showed that both zinc (Zn) and cadmium (Cd) transiently upregulate ZnT-1 mRNA to comparable levels [11].


  1. Integrative aspects of zinc transporters. Cousins, R.J., McMahon, R.J. J. Nutr. (2000) [Pubmed]
  2. Silencing of ZnT-1 expression enhances heavy metal influx and toxicity. Ohana, E., Sekler, I., Kaisman, T., Kahn, N., Cove, J., Silverman, W.F., Amsterdam, A., Hershfinkel, M. J. Mol. Med. (2006) [Pubmed]
  3. Regulation of metallothionein and zinc transporter expression in human prostate cancer cells and tissues. Hasumi, M., Suzuki, K., Matsui, H., Koike, H., Ito, K., Yamanaka, H. Cancer Lett. (2003) [Pubmed]
  4. Alterations in zinc transporter protein-1 (ZnT-1) in the brain of subjects with mild cognitive impairment, early, and late-stage Alzheimer's disease. Lovell, M.A., Smith, J.L., Xiong, S., Markesbery, W.R. Neurotoxicity research. (2005) [Pubmed]
  5. Chromium(VI) down-regulates heavy metal-induced metallothionein gene transcription by modifying transactivation potential of the key transcription factor, metal-responsive transcription factor 1. Majumder, S., Ghoshal, K., Summers, D., Bai, S., Datta, J., Jacob, S.T. J. Biol. Chem. (2003) [Pubmed]
  6. Constitutive expression of hZnT4 zinc transporter in human breast epithelial cells. Michalczyk, A.A., Allen, J., Blomeley, R.C., Ackland, M.L. Biochem. J. (2002) [Pubmed]
  7. A role for ZnT-1 in regulating cellular cation influx. Segal, D., Ohana, E., Besser, L., Hershfinkel, M., Moran, A., Sekler, I. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  8. Differential regulation of zinc efflux transporters ZnT-1, ZnT-5 and ZnT-7 gene expression by zinc levels: a real-time RT-PCR study. Devergnas, S., Chimienti, F., Naud, N., Pennequin, A., Coquerel, Y., Chantegrel, J., Favier, A., Seve, M. Biochem. Pharmacol. (2004) [Pubmed]
  9. Molecular physiology of zinc transport in the Zn hyperaccumulator Thlaspi caerulescens. Lasat, M.M., Pence, N.S., Garvin, D.F., Ebbs, S.D., Kochian, L.V. J. Exp. Bot. (2000) [Pubmed]
  10. Different induction of metallothioneins and Hsp70 and presence of the membrane transporter ZnT-1 in HepG2 cells exposed to copper and zinc. Urani, C., Calini, V., Melchioretto, P., Morazzoni, F., Canevali, C., Camatini, M. Toxicology in vitro : an international journal published in association with BIBRA. (2003) [Pubmed]
  11. Cadmium and zinc induction of ZnT-1 mRNA in an established carp cell line. Muylle, F., Robbens, J., De Coen, W., Timmermans, J.P., Blust, R. Comp. Biochem. Physiol. C Toxicol. Pharmacol. (2006) [Pubmed]
  12. Mammalian zinc transporters. McMahon, R.J., Cousins, R.J. J. Nutr. (1998) [Pubmed]
  13. Survey of mRNAs encoding zinc transporters and other metal complexing proteins in pancreatic islets of rats from birth to adulthood: similar patterns in the Sprague-Dawley and Wistar BB strains. Clifford, K.S., MacDonald, M.J. Diabetes Res. Clin. Pract. (2000) [Pubmed]
  14. Investigation of lymphocyte gene expression for use as biomarkers for zinc status in humans. Andree, K.B., Kim, J., Kirschke, C.P., Gregg, J.P., Paik, H., Joung, H., Woodhouse, L., King, J.C., Huang, L. J. Nutr. (2004) [Pubmed]
  15. Intestinal and placental zinc transport pathways. Ford, D. The Proceedings of the Nutrition Society. (2004) [Pubmed]
  16. Changes in chicken intestinal zinc exporter mRNA expression and small intestinal functionality following intra-amniotic zinc-methionine administration. Tako, E., Ferket, P.R., Uni, Z. J. Nutr. Biochem. (2005) [Pubmed]
  17. Functions of zinc in signaling, proliferation and differentiation of mammalian cells. Beyersmann, D., Haase, H. Biometals (2001) [Pubmed]
  18. Zinc and metallothionein levels and expression of zinc transporters in androgen-independent subline of LNCaP cells. Iguchi, K., Otsuka, T., Usui, S., Ishii, K., Onishi, T., Sugimura, Y., Hirano, K. J. Androl. (2004) [Pubmed]
  19. Zinc transport in the brain: routes of zinc influx and efflux in neurons. Colvin, R.A., Davis, N., Nipper, R.W., Carter, P.A. J. Nutr. (2000) [Pubmed]
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