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Gene Review

Slc30a1  -  solute carrier family 30 (zinc...

Mus musculus

Synonyms: AI839647, C130040I11Rik, Solute carrier family 30 member 1, Zinc transporter 1, ZnT-1, ...
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Disease relevance of Slc30a1

  • We propose that ZnT-1 transports zinc out of cells and that its absence accounts for the increased sensitivity of mutant cells to zinc toxicity [1].

High impact information on Slc30a1

  • It resembles ZnT-1 (a plasma membrane protein that stimulates zinc efflux) in overall topology in that it has six membrane-spanning domains, a histidine-rich intracellular loop and a long C-terminal tail; however, the overall amino acid identity is only 26% [2].
  • A cDNA encoding a zinc transporter (ZnT-1) was isolated from a rat kidney cDNA expression library by complementation of a mutated, zinc-sensitive BHK cell line [1].
  • In this study, the interplay between zinc binding by MT and its efflux by zinc transporter 1 (ZnT1) was examined genetically [3].
  • Only two, ZnT1 and ZnT2 (both cellular Zn exporters), show a progressive down-regulation under Zn-depleted conditions [4].
  • In Zn-adequate mice, ZnT1 is diffusely distributed in acinar cell cytoplasm and colocalizes with alpha-amylase but is not detected in pancreatic islets [4].

Chemical compound and disease context of Slc30a1


Biological context of Slc30a1

  • Changes in ZnT1 gene expression in these experiments paralleled those of metallothionein I (MT-I) [6].
  • Inactivation of the Znt1 gene in baby hamster kidney (BHK) cells that do not express their Mt genes results in a zinc-sensitive phenotype and a high level of "free" zinc [3].
  • Mouse zinc transporter 1 gene provides an essential function during early embryonic development [7].
  • These studies suggest that Znt1 serves an essential function of transporting maternal zinc into the embryonic environment during the egg cylinder stage of development, and further suggest that Znt1 plays a role in zinc homeostasis in adult mice [7].
  • The specific expression of ZnT-1 in the Sertoli cells, moreover, is consistent with their role in maintaining a nurturing, closely regulated environment for spermatogenesis [8].

Anatomical context of Slc30a1


Associations of Slc30a1 with chemical compounds

  • In cells incubated in medium supplemented with Chelex-treated fetal bovine serum, to remove metal ions, levels of ZnT1 mRNA were reduced, and induction of this message in response to zinc or cadmium was accentuated (up to 31-fold induction) [6].
  • Unlike activation of phase II genes by tBHQ, induction of Mt1 expression does not occur in the presence of EDTA, when cells are cultured in zinc-depleted medium, or in cells with reduced intracellular 'free' zinc due to overexpression of ZnT1, a zinc-efflux transporter, indicating that induction requires zinc [9].
  • Co-labeling for ZnT-1 and MT I/II demonstrated unique patterns of distribution for these proteins, with ZnT-1 present in Sertoli cells in addition to luminal spermatozoa and MT I/II restricted to spermatocytes [8].
  • The present study has investigated the effect of DEHP exposure on several key genes in zinc metabolism (MT-I, MT-II, ZnT-1) for early mouse embryos exposed in utero [10].
  • The distribution of ZnT-1 was compared to that of chelatable Zn(2+), visualized by means of neoTimm histochemistry or N-(6-methoxy-8-quinolyl)-p-toluene-sulfonamide (TSQ) histofluorescence [5].

Other interactions of Slc30a1


Analytical, diagnostic and therapeutic context of Slc30a1


  1. Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc. Palmiter, R.D., Findley, S.D. EMBO J. (1995) [Pubmed]
  2. ZnT-2, a mammalian protein that confers resistance to zinc by facilitating vesicular sequestration. Palmiter, R.D., Cole, T.B., Findley, S.D. EMBO J. (1996) [Pubmed]
  3. Protection against zinc toxicity by metallothionein and zinc transporter 1. Palmiter, R.D. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  4. Responsive transporter genes within the murine intestinal-pancreatic axis form a basis of zinc homeostasis. Liuzzi, J.P., Bobo, J.A., Lichten, L.A., Samuelson, D.A., Cousins, R.J. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  5. Distribution of the zinc transporter ZnT-1 in comparison with chelatable zinc in the mouse brain. Sekler, I., Moran, A., Hershfinkel, M., Dori, A., Margulis, A., Birenzweig, N., Nitzan, Y., Silverman, W.F. J. Comp. Neurol. (2002) [Pubmed]
  6. The transcription factor MTF-1 mediates metal regulation of the mouse ZnT1 gene. Langmade, S.J., Ravindra, R., Daniels, P.J., Andrews, G.K. J. Biol. Chem. (2000) [Pubmed]
  7. Mouse zinc transporter 1 gene provides an essential function during early embryonic development. Andrews, G.K., Wang, H., Dey, S.K., Palmiter, R.D. Genesis (2004) [Pubmed]
  8. Zinc-regulating proteins, ZnT-1, and metallothionein I/II are present in different cell populations in the mouse testis. Elgazar, V., Razanov, V., Stoltenberg, M., Hershfinkel, M., Huleihel, M., Nitzan, Y.B., Lunenfeld, E., Sekler, I., Silverman, W.F. J. Histochem. Cytochem. (2005) [Pubmed]
  9. Induction of metallothionein I by phenolic antioxidants requires metal-activated transcription factor 1 (MTF-1) and zinc. Bi, Y., Palmiter, R.D., Wood, K.M., Ma, Q. Biochem. J. (2004) [Pubmed]
  10. Altered expression of genes related to zinc homeostasis in early mouse embryos exposed to di-2-ethylhexyl phthalate. Lee, J., Park, J., Jang, B., Knudsen, T.B. Toxicol. Lett. (2004) [Pubmed]
  11. Increased abundance of labile intracellular zinc during cell proliferation was due to increased retention of extracellular zinc in 3T3 cells. Simpson, M., Xu, Z. J. Nutr. Biochem. (2006) [Pubmed]
  12. Cyproterone acetate induces a cellular tolerance to cadmium in rat liver epithelial cells involving reduced cadmium accumulation. Takiguchi, M., Cherrington, N.J., Hartley, D.P., Klaassen, C.D., Waalkes, M.P. Toxicology (2001) [Pubmed]
  13. Expression profiles of zinc transporters in rodent placental models. Asano, N., Kondoh, M., Ebihara, C., Fujii, M., Nakanishi, T., Soares, M.J., Nakashima, E., Tanaka, K., Sato, M., Watanabe, Y. Toxicol. Lett. (2004) [Pubmed]
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