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Gene Review

PEX25  -  Pex25p

Saccharomyces cerevisiae S288c

Synonyms: Peroxin-25, Peroxisomal membrane protein PEX25, YPL112C
 
 
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High impact information on PEX25

  • Inp1p binds Pex25p, Pex30p, and Vps1p, which have been implicated in controlling peroxisome division [1].
  • Although Rho1p has been shown to be tethered to membranes of the secretory pathway, we show that it is specifically recruited to peroxisomes upon their induction in a process dependent on its interaction with the peroxisome membrane protein Pex25p [2].
  • Overexpression of the genes PEX25 or VPS1, but not the gene PEX11, restored the wild-type phenotype to cells deleted for one or both of the YHR150w and YDR479c genes [3].
  • Together, our data suggest a role for Yhr150p and Ydr479p, together with Pex25p and Vps1p, in regulating peroxisome number, size, and distribution in S. cerevisiae [3].
  • Ypl112p, renamed Pex25p, is a novel peroxin required for the regulation of peroxisome size and maintenance [4].
 

Biological context of PEX25

 

Anatomical context of PEX25

 

Associations of PEX25 with chemical compounds

 

Other interactions of PEX25

  • Yor193p is a peripheral peroxisomal membrane protein that exhibits high sequence similarity not only to Pex25p but also to the peroxisomal membrane peroxin Pex11p [7].

References

  1. Inp1p is a peroxisomal membrane protein required for peroxisome inheritance in Saccharomyces cerevisiae. Fagarasanu, M., Fagarasanu, A., Tam, Y.Y., Aitchison, J.D., Rachubinski, R.A. J. Cell Biol. (2005) [Pubmed]
  2. Quantitative mass spectrometry reveals a role for the GTPase Rho1p in actin organization on the peroxisome membrane. Marelli, M., Smith, J.J., Jung, S., Yi, E., Nesvizhskii, A.I., Christmas, R.H., Saleem, R.A., Tam, Y.Y., Fagarasanu, A., Goodlett, D.R., Aebersold, R., Rachubinski, R.A., Aitchison, J.D. J. Cell Biol. (2004) [Pubmed]
  3. YHR150w and YDR479c encode peroxisomal integral membrane proteins involved in the regulation of peroxisome number, size, and distribution in Saccharomyces cerevisiae. Vizeacoumar, F.J., Torres-Guzman, J.C., Tam, Y.Y., Aitchison, J.D., Rachubinski, R.A. J. Cell Biol. (2003) [Pubmed]
  4. Transcriptome profiling to identify genes involved in peroxisome assembly and function. Smith, J.J., Marelli, M., Christmas, R.H., Vizeacoumar, F.J., Dilworth, D.J., Ideker, T., Galitski, T., Dimitrov, K., Rachubinski, R.A., Aitchison, J.D. J. Cell Biol. (2002) [Pubmed]
  5. Conserved function of pex11p and the novel pex25p and pex27p in peroxisome biogenesis. Rottensteiner, H., Stein, K., Sonnenhol, E., Erdmann, R. Mol. Biol. Cell (2003) [Pubmed]
  6. Saccharomyces cerevisiae Pip2p-Oaf1p regulates PEX25 transcription through an adenine-less ORE. Rottensteiner, H., Hartig, A., Hamilton, B., Ruis, H., Erdmann, R., Gurvitz, A. Eur. J. Biochem. (2003) [Pubmed]
  7. Pex11-related proteins in peroxisome dynamics: a role for the novel peroxin Pex27p in controlling peroxisome size and number in Saccharomyces cerevisiae. Tam, Y.Y., Torres-Guzman, J.C., Vizeacoumar, F.J., Smith, J.J., Marelli, M., Aitchison, J.D., Rachubinski, R.A. Mol. Biol. Cell (2003) [Pubmed]
 
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