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Gene Review

PIP2  -  Pip2p

Saccharomyces cerevisiae S288c

Synonyms: OAF2, Oleate-activated transcription factor 2, Peroxisome proliferation transcriptional regulator, YOR363C
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High impact information on PIP2


Biological context of PIP2


Anatomical context of PIP2


Associations of PIP2 with chemical compounds


Physical interactions of PIP2

  • Studies based on lacZ reporter genes and in vitro protein-DNA interactions revealed that the PEX25 ORE could bind Pip2p-Oaf1p and confer activation on a basal promoter [14].
  • We demonstrate that the induction of Oaf1/Pip2 activity by the fatty acid oleate depends on oleate's direct binding to the Oaf1 LBD [15].

Other interactions of PIP2

  • In addition, the amount of Pip2p-Oaf1p that bound to a target ORE in vitro was reduced in mutant extracts compared with the wild-type [5].
  • Regulation of the yeast SPS19 gene encoding peroxisomal 2,4-dienoyl-CoA reductase by the transcription factors Pip2p and Oaf1p: beta-oxidation is dispensable for Saccharomyces cerevisiae sporulation in acetate medium [6].
  • However, regulation of ODC1 does not require the transcription factors Oaf1p and Pip2p, known to mediate oleic acid induction of other genes [16].
  • UAS(SPS19), which is similar to a transcriptional enhancer in the promoter of the sporulation-specific gene SPS4, was shown specifically to bind several proteins, including Pip2p and Oaflp [17].
  • The PEX25 promoter contains an oleate response element (ORE)-like sequence comprising a CGG palindrome lacking a canonical adenine, which is considered critical for element function and Pip2p-Oaf1p binding [14].

Analytical, diagnostic and therapeutic context of PIP2


  1. Phosphatidylinositol 4 phosphate regulates targeting of clathrin adaptor AP-1 complexes to the Golgi. Wang, Y.J., Wang, J., Sun, H.Q., Martinez, M., Sun, Y.X., Macia, E., Kirchhausen, T., Albanesi, J.P., Roth, M.G., Yin, H.L. Cell (2003) [Pubmed]
  2. Essential role for phosphatidylinositol 4,5-bisphosphate in yeast cell proliferation. Uno, I., Fukami, K., Kato, H., Takenawa, T., Ishikawa, T. Nature (1988) [Pubmed]
  3. Interactions with PIP2, ADP-actin monomers, and capping protein regulate the activity and localization of yeast twinfilin. Palmgren, S., Ojala, P.J., Wear, M.A., Cooper, J.A., Lappalainen, P. J. Cell Biol. (2001) [Pubmed]
  4. Pip2p: a transcriptional regulator of peroxisome proliferation in the yeast Saccharomyces cerevisiae. Rottensteiner, H., Kal, A.J., Filipits, M., Binder, M., Hamilton, B., Tabak, H.F., Ruis, H. EMBO J. (1996) [Pubmed]
  5. Saccharomyces cerevisiae PIP2 mediating oleic acid induction and peroxisome proliferation is regulated by Adr1p and Pip2p-Oaf1p. Rottensteiner, H., Wabnegger, L., Erdmann, R., Hamilton, B., Ruis, H., Hartig, A., Gurvitz, A. J. Biol. Chem. (2003) [Pubmed]
  6. Regulation of the yeast SPS19 gene encoding peroxisomal 2,4-dienoyl-CoA reductase by the transcription factors Pip2p and Oaf1p: beta-oxidation is dispensable for Saccharomyces cerevisiae sporulation in acetate medium. Gurvitz, A., Rottensteiner, H., Hiltunen, J.K., Binder, M., Dawes, I.W., Ruis, H., Hamilton, B. Mol. Microbiol. (1997) [Pubmed]
  7. Peroxisomal degradation of trans-unsaturated fatty acids in the yeast Saccharomyces cerevisiae. Gurvitz, A., Hamilton, B., Ruis, H., Hartig, A. J. Biol. Chem. (2001) [Pubmed]
  8. A heterodimer of the Zn2Cys6 transcription factors Pip2p and Oaf1p controls induction of genes encoding peroxisomal proteins in Saccharomyces cerevisiae. Rottensteiner, H., Kal, A.J., Hamilton, B., Ruis, H., Tabak, H.F. Eur. J. Biochem. (1997) [Pubmed]
  9. Global regulatory functions of Oaf1p and Pip2p (Oaf2p), transcription factors that regulate genes encoding peroxisomal proteins in Saccharomyces cerevisiae. Karpichev, I.V., Small, G.M. Mol. Cell. Biol. (1998) [Pubmed]
  10. Phosphatidylinositol transfer proteins: a requirement in signal transduction and vesicle traffic. Cockcroft, S. Bioessays (1998) [Pubmed]
  11. The stress-activated phosphatidylinositol 3-phosphate 5-kinase Fab1p is essential for vacuole function in S. cerevisiae. Cooke, F.T., Dove, S.K., McEwen, R.K., Painter, G., Holmes, A.B., Hall, M.N., Michell, R.H., Parker, P.J. Curr. Biol. (1998) [Pubmed]
  12. Effects of acid phospholipids on nucleotide exchange properties of ADP-ribosylation factor 1. Evidence for specific interaction with phosphatidylinositol 4,5-bisphosphate. Terui, T., Kahn, R.A., Randazzo, P.A. J. Biol. Chem. (1994) [Pubmed]
  13. Genetic and biochemical characterization of a phosphatidylinositol-specific phospholipase C in Saccharomyces cerevisiae. Flick, J.S., Thorner, J. Mol. Cell. Biol. (1993) [Pubmed]
  14. Saccharomyces cerevisiae Pip2p-Oaf1p regulates PEX25 transcription through an adenine-less ORE. Rottensteiner, H., Hartig, A., Hamilton, B., Ruis, H., Erdmann, R., Gurvitz, A. Eur. J. Biochem. (2003) [Pubmed]
  15. Fungi and animals may share a common ancestor to nuclear receptors. Phelps, C., Gburcik, V., Suslova, E., Dudek, P., Forafonov, F., Bot, N., Maclean, M., Fagan, R.J., Picard, D. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  16. Yeast mitochondrial oxodicarboxylate transporters are important for growth on oleic acid. Tibbetts, A.S., Sun, Y., Lyon, N.A., Ghrist, A.C., Trotter, P.J. Arch. Biochem. Biophys. (2002) [Pubmed]
  17. A novel element in the promoter of the Saccharomyces cerevisiae gene SPS19 enhances ORE-dependent up-regulation in oleic acid and is essential for de-repression. Gurvitz, A., Hamilton, B., Hartig, A., Ruis, H., Dawes, I.W., Rottensteiner, H. Mol. Gen. Genet. (1999) [Pubmed]
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