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Gene Review

COX6  -  cytochrome c oxidase subunit VI

Saccharomyces cerevisiae S288c

Synonyms: Cytochrome c oxidase polypeptide VI, Cytochrome c oxidase subunit 6, mitochondrial, YHR051W
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High impact information on COX6

  • In contrast, mRNAs encoding Cox6p, Cox5a, Aac1p, and Mir1p are found enriched in free cytoplasmic polysome fractions [1].
  • Domain 1 is essential for transcription per se in cells grown on repressing carbon sources, is required for optimal transcription in cells grown on a derepressing carbon source, is sufficient for glucose repression-derepression, and is the element of UAS6 at which HAP2 affects COX6 transcription [2].
  • ABF1 is a phosphoprotein and plays a role in carbon source control of COX6 transcription in Saccharomyces cerevisiae [3].
  • The phosphorylation patterns that we have observed correlate with the regulation of a specific target gene, COX6, which encodes subunit VI of cytochrome c oxidase [3].
  • In an ssn6 mutant genetic background, both COX6 and CYC1 were expressed constitutively at high levels in repressing media [4].

Biological context of COX6

  • Through 5' deletion analysis we have also found that the effects of heme and HAP2 on COX6 are mediated by sequences between 135 and 590 base pairs upstream of its initiation codon [5].
  • In this study, by deletion mutagenesis of the COX6 promoter, we identified two regions that are important for transcription [6].
  • It contained two of the three major 5' termini of COX6 mRNAs and a putative TATA box [6].
  • The nucleotide sequence of COX6 also predicts that subunit VI is derived from a precursor with a highly basic 40-amino acid NH2-terminal presequence [7].
  • An additional open reading frame, consisting of 82 codons, terminates 22 codons upstream from COX6 [7].

Regulatory relationships of COX6

  • These findings identify COX6 as the fourth respiratory protein gene that is known to be regulated positively by heme and HAP2 [5].

Other interactions of COX6


Analytical, diagnostic and therapeutic context of COX6

  • Northern blot analysis of poly(A+) RNA from strain D273-10B reveals that COX6 is homologous to three RNAs of 1800, 900, and 700 bases in length [7].


  1. In yeast, the 3' untranslated region or the presequence of ATM1 is required for the exclusive localization of its mRNA to the vicinity of mitochondria. Corral-Debrinski, M., Blugeon, C., Jacq, C. Mol. Cell. Biol. (2000) [Pubmed]
  2. Regulation of yeast COX6 by the general transcription factor ABF1 and separate HAP2- and heme-responsive elements. Trawick, J.D., Kraut, N., Simon, F.R., Poyton, R.O. Mol. Cell. Biol. (1992) [Pubmed]
  3. ABF1 is a phosphoprotein and plays a role in carbon source control of COX6 transcription in Saccharomyces cerevisiae. Silve, S., Rhode, P.R., Coll, B., Campbell, J., Poyton, R.O. Mol. Cell. Biol. (1992) [Pubmed]
  4. Release of two Saccharomyces cerevisiae cytochrome genes, COX6 and CYC1, from glucose repression requires the SNF1 and SSN6 gene products. Wright, R.M., Poyton, R.O. Mol. Cell. Biol. (1990) [Pubmed]
  5. Transcription of yeast COX6, the gene for cytochrome c oxidase subunit VI, is dependent on heme and on the HAP2 gene. Trawick, J.D., Wright, R.M., Poyton, R.O. J. Biol. Chem. (1989) [Pubmed]
  6. Identification of an upstream activation sequence and other cis-acting elements required for transcription of COX6 from Saccharomyces cerevisiae. Trawick, J.D., Rogness, C., Poyton, R.O. Mol. Cell. Biol. (1989) [Pubmed]
  7. Isolation and sequence of the structural gene for cytochrome c oxidase subunit VI from Saccharomyces cerevisiae. Wright, R.M., Ko, C., Cumsky, M.G., Poyton, R.O. J. Biol. Chem. (1984) [Pubmed]
  8. Oxygen regulation of the cytochrome c oxidase subunit VI gene, COX6, in Saccharomyces cerevisiae. Wright, R.M., Simpson, S.L., Lanoil, B.D. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
  9. Mitochondrial function is required for resistance to oxidative stress in the yeast Saccharomyces cerevisiae. Grant, C.M., MacIver, F.H., Dawes, I.W. FEBS Lett. (1997) [Pubmed]
  10. Affinity purification of yeast cytochrome oxidase with biotinylated subunits 4, 5, or 6. Glerum, D.M., Tzagoloff, A. Anal. Biochem. (1998) [Pubmed]
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