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Gene Review

FCY2  -  Fcy2p

Saccharomyces cerevisiae S288c

Synonyms: Cytosine/purine transport protein FCY2, Fluorocytosine resistance protein 2, PCP FCY2, Purine-cytosine permease FCY2, YER056C
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Disease relevance of FCY2

  • By applying a highly sensitive assay, a low-level but dose-dependent toxicity of 5-FC in fcy2 mutants was detected, whereas cells deficient in the cytosine deaminase (encoded by FCY1), which is essential for intracellular conversion of 5-FC to 5-fluorouracil, display strong dose-independent resistance [1].

High impact information on FCY2


Biological context of FCY2


Anatomical context of FCY2


Associations of FCY2 with chemical compounds


Analytical, diagnostic and therapeutic context of FCY2

  • In ELISA, sera reacted with the synthetic peptide and with specific proteins of plasma-membrane-enriched fractions of mutant Saccharomyces cerevisiae pAB strains (amplified FCY2 gene) with high titers and high avidity [6].


  1. Various cytosine/adenine permease homologues are involved in the toxicity of 5-fluorocytosine in Saccharomyces cerevisiae. Paluszynski, J.P., Klassen, R., Rohe, M., Meinhardt, F. Yeast (2006) [Pubmed]
  2. The purine-cytosine permease gene of Saccharomyces cerevisiae: primary structure and deduced protein sequence of the FCY2 gene product. Weber, E., Rodriguez, C., Chevallier, M.R., Jund, R. Mol. Microbiol. (1990) [Pubmed]
  3. The isolation and characterization of Saccharomyces cerevisiae mutants that constitutively express purine biosynthetic genes. Guetsova, M.L., Lecoq, K., Daignan-Fornier, B. Genetics (1997) [Pubmed]
  4. New plasmid system to select for Saccharomyces cerevisiae purine-cytosine permease affinity mutants. Wagner, R., Straub, M.L., Souciet, J.L., Potier, S., de Montigny, J. J. Bacteriol. (2001) [Pubmed]
  5. In vivo and in vitro studies of the purine-cytosine permease of Saccharomyces cerevisiae. Functional analysis of a mutant with an altered apparent transport constant of uptake. Brèthes, D., Chirio, M.C., Napias, C., Chevallier, M.R., Lavie, J.L., Chevallier, J. Eur. J. Biochem. (1992) [Pubmed]
  6. Detection of purine cytosine permease of S. cerevisiae: use of antibodies against a synthetic peptide corresponding to a predicted sequence in the N-terminal domain of the protein. Grandier-Vazeille, X., Neaud, V., Geoffre, S. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  7. In vivo phosphorylation of the purine/cytosine permease from the plasma membrane of the yeast Saccharomyces cerevisiae. Pinson, B., Pillois, X., Brèthes, D., Chevallier, J., Napias, C. Eur. J. Biochem. (1996) [Pubmed]
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