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Gene Review

HIS1  -  ATP phosphoribosyltransferase

Saccharomyces cerevisiae S288c

Synonyms: ATP-PRT, ATP-PRTase, YER055C
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High impact information on HIS1


Biological context of HIS1


Anatomical context of HIS1


Other interactions of HIS1

  • Each of the his1-his7 mutant strains were unable to grow in the presence of elevated levels of Cu, Co, or Ni at nearly neutral pHs, in contrast to His(+) strains, which grew under these conditions [9].
  • Treatment of S. pombe cells with 3-AT leads to a small increase in the level of the his5 transcript, but no effect is seen on the level of the his1 transcript [10].
  • All 8 induced 2-5-fold increases in reversion frequencies over background at the trp5 locus--5 of these induced 1.5-3-fold increases at the hom3 locus and 1 induced a doubling at his1 [11].

Analytical, diagnostic and therapeutic context of HIS1

  • The resulting heterogeneity of the HIS1/KanMX4 markers, together with quantitative PCR and densitometric analysis on chromosome V, confirmed its diploid complement, thereby indicating that an endoreduplication event had taken place [8].


  1. Structure of the yeast HOM3 gene which encodes aspartokinase. Rafalski, J.A., Falco, S.C. J. Biol. Chem. (1988) [Pubmed]
  2. Repeated DNA sequences upstream from HIS1 also occur at several other co-regulated genes in Saccharomyces cerevisiae. Hinnebusch, A.G., Fink, G.R. J. Biol. Chem. (1983) [Pubmed]
  3. The purine-cytosine permease gene of Saccharomyces cerevisiae: primary structure and deduced protein sequence of the FCY2 gene product. Weber, E., Rodriguez, C., Chevallier, M.R., Jund, R. Mol. Microbiol. (1990) [Pubmed]
  4. Reversion at the HiS1 locus of yeast. Fogel, S., Lax, C., Hurst, D.D. Genetics (1978) [Pubmed]
  5. Gene-enzyme relationships in the proline biosynthetic pathway of Saccharomyces cerevisiae. Tomenchok, D.M., Brandriss, M.C. J. Bacteriol. (1987) [Pubmed]
  6. The predicted presence of large helical structural variation in yeast HIS4 upstream region is correlated with general amino acid control on the CYC1 gene. Nussinov, R. J. Biomol. Struct. Dyn. (1985) [Pubmed]
  7. Cloning of the Candida albicans HIS1 gene by direct complementation of a C. albicans histidine auxotroph using an improved double-ARS shuttle vector. Pla, J., Pérez-Díaz, R.M., Navarro-García, F., Sánchez, M., Nombela, C. Gene (1995) [Pubmed]
  8. Chromosome V loss due to centromere knockout or MAD2-deletion is immediately followed by restitution of homozygous diploidy in Saccharomyces cerevisiae. Zang, Y., Garrè, M., Gjuracic, K., Bruschi, C.V. Yeast (2002) [Pubmed]
  9. Toxicity of copper, cobalt, and nickel salts is dependent on histidine metabolism in the yeast Saccharomyces cerevisiae. Pearce, D.A., Sherman, F. J. Bacteriol. (1999) [Pubmed]
  10. Characterization of Schizosaccharomyces pombe his1 and his5 cDNAs. Erickson, F.L., Hannig, E.M. Yeast (1995) [Pubmed]
  11. Mutagenicity of constituents of pulp and paper mill effluent in growing cells of Saccharomyces cerevisiae. Nestmann, E.R., Lee, E.G. Mutat. Res. (1983) [Pubmed]
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