Gene Review:
MOT2 - CCR4-NOT core ubiquitin-protein ligase...
Saccharomyces cerevisiae S288c
Synonyms:
CCL1, General negative regulator of transcription subunit 4, Modulator of transcription 2, NOT4, SIG1, ...
- The yeast MOT2 gene encodes a putative zinc finger protein that serves as a global negative regulator affecting expression of several categories of genes, including mating-pheromone-responsive genes. Irie, K., Yamaguchi, K., Kawase, K., Matsumoto, K. Mol. Cell. Biol. (1994)
- NOT1(CDC39), NOT2(CDC36), NOT3, and NOT4 encode a global-negative regulator of transcription that differentially affects TATA-element utilization. Collart, M.A., Struhl, K. Genes Dev. (1994)
- The Ccr4-not complex and yTAF1 (yTaf(II)130p/yTaf(II)145p) show physical and functional interactions. Deluen, C., James, N., Maillet, L., Molinete, M., Theiler, G., Lemaire, M., Paquet, N., Collart, M.A. Mol. Cell. Biol. (2002)
- MOT2 encodes a negative regulator of gene expression that affects basal expression of pheromone-responsive genes in Saccharomyces cerevisiae. Cade, R.M., Errede, B. Mol. Cell. Biol. (1994)
- Deletion of the NOT4 gene impairs hyphal development and pathogenicity in Candida albicans. Krueger, K.E., Ghosh, A.K., Krom, B.P., Cihlar, R.L. Microbiology (Reading, Engl.) (2004)
- Genetic evidence supports a role for the yeast CCR4-NOT complex in transcriptional elongation. Denis, C.L., Chiang, Y.C., Cui, Y., Chen, J. Genetics (2001)
- The inactivation of KlNOT4, a Kluyveromyces lactis gene encoding a component of the CCR4-NOT complex, reveals new regulatory functions. Mazzoni, C., Serafini, A., Falcone, C. Genetics (2005)
- DNA damage and replication stress induced transcription of RNR genes is dependent on the Ccr4-Not complex. Mulder, K.W., Winkler, G.S., Timmers, H.T. Nucleic Acids Res. (2005)
- Characterization of NOT5 that encodes a new component of the Not protein complex. Oberholzer, U., Collart, M.A. Gene (1998)
- The TATA-binding protein-associated factor yTafII19p functionally interacts with components of the global transcriptional regulator Ccr4-Not complex and physically interacts with the Not5 subunit. Lemaire, M., Collart, M.A. J. Biol. Chem. (2000)
- The Yeast Ccr4-Not Complex Controls Ubiquitination of the Nascent-associated Polypeptide (NAC-EGD) Complex. Panasenko, O., Landrieux, E., Feuermann, M., Finka, A., Paquet, N., Collart, M.A. J. Biol. Chem. (2006)