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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review

CDK13  -  cyclin-dependent kinase 13

Homo sapiens

Synonyms: CDC2-related protein kinase 5, CDC2L, CDC2L5, CHED, Cell division cycle 2-like protein kinase 5, ...
 
 
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Disease relevance of CDC2L5

  • We propose that aberrations in the CDC2L genes may contribute to the pathogenesis or progression of melanoma [1].
 

High impact information on CDC2L5

  • Therefore, these findings strengthen the link between cholinergic signaling and cell division control in hematopoiesis and implicate both CHED and cholinesterases in this differentiation process [2].
  • Library screening, RNA blot hybridization, and direct PCR amplification of cDNA reverse-transcribed from cellular mRNA revealed that CHED mRNA is expressed in multiple tissues, including bone marrow [2].
  • AS-CHED treatment selectively inhibited megakaryocyte development in murine bone marrow cultures but did not prevent other hematopoietic pathways, as evidenced by increasing numbers of mononuclear cells [2].
  • The CHED protein includes the consensus ATP binding and phosphorylation domains characteristic of kinases, displays 34-42% identically aligned amino acid residues with other cdc2-related kinases, and is considerably longer at its amino and carboxyl termini [2].
  • We now present cloning of a cDNA coding for CHED (cholinesterase-related cell division controller), a human homolog of the Schizosaccharomyces pombe cell division cycle 2 (cdc2)-like kinases, universal controllers of the mitotic cell cycle [2].
 

Biological context of CDC2L5

 

Physical interactions of CDC2L5

 

Other interactions of CDC2L5

  • In the present work, we identified sea urchin and human cDNAs encoding homologues of a high molecular mass CDC2-like kinase (designated CDC2L5) sharing respectively a PITAVRE and PITAIRE motif [4].
 

Analytical, diagnostic and therapeutic context of CDC2L5

References

  1. Abnormalities in the p34cdc2-related PITSLRE protein kinase gene complex (CDC2L) on chromosome band 1p36 in melanoma. Nelson, M.A., Ariza, M.E., Yang, J.M., Thompson, F.H., Taetle, R., Trent, J.M., Wymer, J., Massey-Brown, K., Broome-Powell, M., Easton, J., Lahti, J.M., Kidd, V.J. Cancer Genet. Cytogenet. (1999) [Pubmed]
  2. Cloning and antisense oligodeoxynucleotide inhibition of a human homolog of cdc2 required in hematopoiesis. Lapidot-Lifson, Y., Patinkin, D., Prody, C.A., Ehrlich, G., Seidman, S., Ben-Aziz, R., Benseler, F., Eckstein, F., Zakut, H., Soreq, H. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  3. CDK13/CDC2L5 interacts with L-type cyclins and regulates alternative splicing. Chen, H.H., Wong, Y.H., Geneviere, A.M., Fann, M.J. Biochem. Biophys. Res. Commun. (2007) [Pubmed]
  4. A new subfamily of high molecular mass CDC2-related kinases with PITAI/VRE motifs. Marqués, F., Moreau, J.L., Peaucellier, G., Lozano, J.C., Schatt, P., Picard, A., Callebaut, I., Perret, E., Genevière, A.M. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  5. Results of penetrating keratoplasty in CHED. Congenital hereditary endothelial dystrophy. Sajjadi, H., Javadi, M.A., Hemmati, R., Mirdeghan, A., Parvin, M., Nassiri, N. Cornea (1995) [Pubmed]
 
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