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Gene Review

betB  -  betaine aldehyde dehydrogenase

Pseudomonas aeruginosa PAO1

 
 
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Disease relevance of betB

 

High impact information on betB

  • As with every aldehyde dehydrogenase studied so far, BADH possesses an essential cysteine residue involved in the formation of the intermediate thiohemiacetal with the aldehyde substrate [1].
  • Betaine aldehyde dehydrogenase (BADH) catalyses the irreversible NAD(P)(+)-dependent oxidation of betaine aldehyde to glycine betaine [1].
  • Thus it seems that to gain protection against oxidation without compromising catalytic efficiency, BADH from P. aeruginosa has evolved a complex and previously undescribed mechanism, involving several conformational rearrangements of the active site, to suit the reactivity of the essential thiol to the availability of coenzyme and substrate [1].
  • The kinetics of P. aeruginosa BADH is very similar to that of glucose-6-phosphate dehydrogenase, suggesting that both enzymes fulfil a similar amphibolic metabolic role when the bacteria grow in choline and when they grow in glucose [2].
  • Steady-state kinetic mechanism of the NADP+- and NAD+-dependent reactions catalysed by betaine aldehyde dehydrogenase from Pseudomonas aeruginosa [2].
 

Chemical compound and disease context of betB

 

Associations of betB with chemical compounds

References

  1. Modulation of the reactivity of the essential cysteine residue of betaine aldehyde dehydrogenase from Pseudomonas aeruginosa. González-Segura, L., Velasco-García, R., Muñoz-Clares, R.A. Biochem. J. (2002) [Pubmed]
  2. Steady-state kinetic mechanism of the NADP+- and NAD+-dependent reactions catalysed by betaine aldehyde dehydrogenase from Pseudomonas aeruginosa. Velasco-García, R., González-Segura, L., Muñoz-Clares, R.A. Biochem. J. (2000) [Pubmed]
  3. Disulfiram irreversibly aggregates betaine aldehyde dehydrogenase--a potential target for antimicrobial agents against Pseudomonas aeruginosa. Velasco-García, R., Zaldívar-Machorro, V.J., Mújica-Jiménez, C., González-Segura, L., Muñoz-Clares, R.A. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  4. Inactivation of betaine aldehyde dehydrogenase from Pseudomonas aeruginosa and Amaranthus hypochondriacus L. leaves by disulfiram. Velasco-García, R., Chacón-Aguilar, V.M., Hervert-Hernández, D., Muñoz-Clares, R.A. Chem. Biol. Interact. (2003) [Pubmed]
 
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