Psychiatry related information on CH25H

• Association studies of cholesterol metabolism genes (CH25H, ABCA1 and CH24H) in Alzheimer's disease [1].

High impact information on CH25H

• The cholesterol 25-hydroxylase gene lacks introns, and in the human it is located on chromosome 10q23 [2].
• Unlike most other sterol hydroxylases, cholesterol 25-hydroxylase is not a cytochrome P450, but rather it is a member of a small family of enzymes that utilize diiron cofactors to catalyze the hydroxylation of hydrophobic substrates [2].
• Using 286 patients with AD and 162 controls we analyzed several single nucleotide polymorphisms (SNPs) within LIPA, CH25H, and FLJ22476 [3].
• Cholesterol 25-hydroxylase (CH25H) is an enzyme converting cholesterol into 25-hydroxycholesterol [4].
• Here we show that 10 nM 1alpha,25(OH)2D3 and 500 nM 25OHD3 upregulate CH25H mRNA expression in human primary prostate stromal cells (P29SN) [4].

Biological context of CH25H

• 1alpha,25(OH)2D3 has no effect on CH25H mRNA stability [4].
• Protein synthesis inhibitor cycloheximide does not block 1alpha,25(OH)2D3 mediated upregulation of CH25H mRNA [4].
• A CH25H enzyme inhibitor, desmosterol, increases basal cell number but has no significant effect on vitamin D3 treated cells [4].
• Sequencing of the 5' region of CH25H revealed three common haplotypes, CH25Hchi2, CH25Hchi3 and CH25Hchi4; CSF levels of the cholesterol precursor lathosterol were higher in carriers of the CH25Hchi4 haplotype [5].

Associations of CH25H with chemical compounds

• Transcription inhibitor actinomycin D blocks basal level as well as 1alpha,25(OH)2D3 induced CH25H mRNA expression [4].

References