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MeSH Review

Transurethral Resection of Prostate

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Disease relevance of Transurethral Resection of Prostate


High impact information on Transurethral Resection of Prostate


Chemical compound and disease context of Transurethral Resection of Prostate


Biological context of Transurethral Resection of Prostate

  • OBJECTIVE: To determine whether antisepsis with povidone-iodine solution applied at the external urethral meatus confers protection against infective complications following transurethral resection of the prostate (TURP) and compare that with antibacterial prophylaxis [14].
  • Absorption of glycine solution during transurethral resection of the prostate (TURP) changes the serum concentrations of most non-essential amino acids and inhibits diuresis by stimulating release of vasopressin [15].
  • A significant reduction in lymphocyte numbers and in the response of lymphocytes to the mitogens PPD and PWM and to histocompatibility antigens in mixed lymphocyte culture was seen in patients after TURP under a general anaesthetic but minimal changes were found in the patients who had a spinal anaesthetic [16].
  • RESULTS: Follow-up data at 2 years show a comparable, significant and maintained improvement in mean IPSS (TUVP: 4.3 vs. TURP: 6.3), quality of life score (TUVP: 1. 1 vs. TURP: 1.7), and maximum flow rate (TUVP: 22.4 vs. TURP: 21.2 ml/s) with fall in mean post-void residual volume (TUVP: 18.8 vs. TURP: 22.8 ml) [17].
  • METHODS: All TURP specimens accessioned to the general surgical pathology service of the Johns Hopkins Hospital (JHH) from March 1984 through December 1987 that did not contain adenocarcinoma of the prostate were reviewed for the presence of high-grade PIN (PIN 2 and PIN 3) [18].

Anatomical context of Transurethral Resection of Prostate

  • It also suggests a potential clinical benefit that might be derived by applying Lanreotide directly to the surgically traumatised genitourinary area by simple irrigation of the urethra and bladder during or shortly post TURP [19].
  • OBJECTIVE: To measure expression of vascular endothelial growth factor (VEGF) and microvessel density (MVD) in the prostates of men after transurethral resection of the prostate (TURP) following 2 weeks of treatment with finasteride [20].
  • To evaluate the role of small amounts of DHT in prostate tissue as a stimulus to epithelial cell growth (protein synthesis) we studied tissue from patients given various androgen-blocking drugs prior to transurethral resection of the prostate (TURP) and measured epithelial protein synthesis and DHT in the tissue specimens [21].

Associations of Transurethral Resection of Prostate with chemical compounds


Gene context of Transurethral Resection of Prostate

  • Adjacent serial sections of formalin-fixed, paraffin-embedded tumor specimens from TURPs on 51 consecutive patients with prostate carcinoma were immunostained for CD34 and von Willebrand Factor (vWF) [27].
  • After TURP, patients were randomly assigned to receive or not receive a COX-2 inhibitor (rofecoxib 25 mg/day) [28].
  • OBJECTIVES: To analyze whether the addition of a cyclooxygenase (COX)-2 inhibitor after transurethral resection of the prostate (TURP) offers an advantage compared with TURP alone in reducing postoperative urethral strictures [28].
  • TURP tissue contained mRNA for PKG Ialpha, Ibeta, and II and the K(ATP) channel subunits Kir6.1, Kir6.2, SUR2B, and SUR1 [29].
  • Optimal conditions for the quantitation of free prolactin binding components of human prostatic tissue obtained by TURP were studied by applying gamma receptor assay [30].

Analytical, diagnostic and therapeutic context of Transurethral Resection of Prostate

  • Norepinephrine levels were also measured in tissue specimens obtained from men undergoing enucleation prostatectomy and transurethral resection of the prostate (TURP) [31].
  • The distribution of cases using 34 beta E12 was 52% needle biopsies, 32% transurethral prostatic resections (TURPs) [32].
  • CONCLUSIONS: Urinary incontinence developed in 18% of patients who underwent TURP following prostate brachytherapy [33].
  • RT-PCR of two ubiquitously expressed gene transcripts (Galpha11, 256 bp and HPRT, 847 bp) yielded products of similar size and intensity between TURP and open prostatectomy derived samples [34].
  • A 55-year-old man on chronic hemodialysis underwent a transurethral resection of the prostate (TURP), during which 3% sorbitol solution was used for urethral irrigation [24].


  1. Effect of megestrol acetate (Megace) on steroid metabolism and steroid-protein binding in the human prostate. Geller, J., Albert, J., Geller, S., Lopez, D., Cantor, T., Yen, S. J. Clin. Endocrinol. Metab. (1976) [Pubmed]
  2. DNA analysis by flow cytometry of paraffin embedded core biopsies of the prostate. Warzynski, M.J., Soechtig, C.E., Maatman, T.J., Goldsmith, L.C., Carothers, G.C. Prostate (1994) [Pubmed]
  3. Prevention of bacteriuria after transurethral prostatectomy with nitrofurantoin macrocrystals. Matthew, A.D., Gonzalez, R., Jeffords, D., Pinto, M.H. J. Urol. (1978) [Pubmed]
  4. The post-transurethral resection of prostate syndrome: therapeutic proposals. Agarwal, R., Emmett, M. Am. J. Kidney Dis. (1994) [Pubmed]
  5. Transurethral resection of the prostate, serum glycine levels, and ocular evoked potentials. Wang, J.M., Creel, D.J., Wong, K.C. Anesthesiology (1989) [Pubmed]
  6. Mortality after prostatectomy: selection and surgical approach. Seagroatt, V. Lancet (1995) [Pubmed]
  7. Monitoring of TURP with ethanol. Hahn, R.G. Lancet (1991) [Pubmed]
  8. Finasteride: an update of its use in the management of symptomatic benign prostatic hyperplasia. Wilde, M.I., Goa, K.L. Drugs (1999) [Pubmed]
  9. Accumulation of glycolic acid and glyoxylic acid in serum in cases of transient hyperglycinemia after transurethral surgery. Perier, C., Frey, J., Auboyer, C., Richard, A., Aulagnier, G., Heritier, P., Gilloz, A. Clin. Chem. (1988) [Pubmed]
  10. Increased serum total creatine kinase and creatine kinase isoenzyme MB after cryosurgical ablation of the prostate. Long, J.P., Fallick, M.L., Rand, W. J. Urol. (1997) [Pubmed]
  11. Hormone therapy for locally advanced prostate cancer. Fowler, J.E., Bigler, S.A., White, P.C., Duncan, W.L. J. Urol. (2002) [Pubmed]
  12. Another feature of TURP syndrome: hyperglycaemia and lactic acidosis caused by massive absorption of sorbitol. Trépanier, C.A., Lessard, M.R., Brochu, J., Turcotte, G. British journal of anaesthesia. (2001) [Pubmed]
  13. Effect of intrathecal tramadol administration on postoperative pain after transurethral resection of prostate. Alhashemi, J.A., Kaki, A.M. British journal of anaesthesia. (2003) [Pubmed]
  14. Comparison of local povidone-iodine antisepsis with parenteral antibacterial prophylaxis for prevention of infective complications of TURP: a prospective randomized controlled study. Ibrahim, A.I., Rashid, M. Eur. Urol. (2002) [Pubmed]
  15. Vasopressin and amino acid concentrations in serum following absorption of irrigating fluid containing glycine and ethanol. Hahn, R.G., Rundgren, M. British journal of anaesthesia. (1989) [Pubmed]
  16. Immunological responsiveness after transurethral resection of the prostate: general versus spinal anaesthetic. Whelan, P., Morris, P.J. Clin. Exp. Immunol. (1982) [Pubmed]
  17. Two-year follow-up of a prospective randomised trial of electrovaporization versus resection of prostate. Hammadeh, M.Y., Madaan, S., Singh, M., Philp, T. Eur. Urol. (1998) [Pubmed]
  18. Incidence and clinical significance of high-grade prostatic intraepithelial neoplasia in TURP specimens. Gaudin, P.B., Sesterhenn, I.A., Wojno, K.J., Mostofi, F.K., Epstein, J.I. Urology (1997) [Pubmed]
  19. Proliferative response of human prostate tumour xenografts to surgical trauma and the transurethral resection of the prostate controversy. Bogden, A.E., LePage, D., Zwicker, S., Grant, W., Silver, M. Br. J. Cancer (1996) [Pubmed]
  20. Randomized, placebo-controlled trial showing that finasteride reduces prostatic vascularity rapidly within 2 weeks. Donohue, J.F., Hayne, D., Karnik, U., Thomas, D.R., Foster, M.C. BJU international. (2005) [Pubmed]
  21. Effect of antiandrogen and/or antiestrogen blockade on human prostate epithelial and stromal cell protein synthesis. Geller, J., Liu, J., Albert, J., Fay, W., Berry, C.C. J. Steroid Biochem. (1986) [Pubmed]
  22. A comparison of 1.5% glycine and 2.7% sorbitol-0.5% mannitol irrigants during transurethral prostate resection. Inman, R.D., Hussain, Z., Elves, A.W., Hallworth, M.J., Jones, P.W., Coppinger, S.W. J. Urol. (2001) [Pubmed]
  23. Low-dose intrathecal morphine for postoperative pain control in patients undergoing transurethral resection of the prostate. Kirson, L.E., Goldman, J.M., Slover, R.B. Anesthesiology (1989) [Pubmed]
  24. Severe hyponatremia without severe hypoosmolality following transurethral resection of the prostate (TURP) in end-stage renal disease. Campbell, H.T., Fincher, M.E., Sklar, A.H. Am. J. Kidney Dis. (1988) [Pubmed]
  25. Short-term prophylaxis with cefotaxime in prostatic surgery. Botto, H., Richard, F., Mathieu, F., Perreau, A.M., Camey, M. J. Antimicrob. Chemother. (1984) [Pubmed]
  26. Sexual Function of LUTS Patients Before and After Neodymium Laser Prostatectomy and Transurethral Resection of Prostate. A Prospective, Randomized Trial. Seftel, A. J. Urol. (2005) [Pubmed]
  27. Comparison of methods of microvascular staining and quantification in prostate carcinoma: relevance to prognosis. Offersen, B.V., Borre, M., Sørensen, F.B., Overgaard, J. APMIS (2002) [Pubmed]
  28. Use of cyclooxygenase-2 inhibitor for prevention of urethral strictures secondary to transurethral resection of the prostate. Sciarra, A., Salciccia, S., Albanesi, L., Cardi, A., D'Eramo, G., Di Silverio, F. Urology (2005) [Pubmed]
  29. Protein kinase G-induced activation of K(ATP) channels reduces contractility of human prostate tissue. Haynes, J.M., Cook, A.L. Prostate (2006) [Pubmed]
  30. Unoccupied prolactin binding components of the benign and malignant human prostate in a subclinical and clinical procedure. Tarle, M., Culig, Z., Kokić, I. International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology. (1989) [Pubmed]
  31. Determination of norepinephrine levels in the adult human prostate. Lepor, H., Shapiro, E., Bowsher, R.R., Henry, D.P. J. Urol. (1990) [Pubmed]
  32. The utility of basal cell-specific anti-cytokeratin antibody (34 beta E12) in the diagnosis of prostate cancer. A review of 228 cases. Wojno, K.J., Epstein, J.I. Am. J. Surg. Pathol. (1995) [Pubmed]
  33. Urinary morbidity and incontinence following transurethral resection of the prostate after brachytherapy. Kollmeier, M.A., Stock, R.G., Cesaretti, J., Stone, N.N. J. Urol. (2005) [Pubmed]
  34. Quality of nucleic acids extracted from fresh prostatic tissue obtained from TURP procedures. Margan, S.H., Handelsman, D.J., Mann, S., Russell, P., Rogers, J., Khadra, M.H., Dong, Q. J. Urol. (2000) [Pubmed]
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