Gene Review:
PEX19 - peroxisomal biogenesis factor 19
Homo sapiens
Synonyms:
33 kDa housekeeping protein, D1S2223E, HK33, OK/SW-cl.22, PBD12A, ...
- Domain architecture and activity of human Pex19p, a chaperone-like protein for intracellular trafficking of peroxisomal membrane proteins. Shibata, H., Kashiwayama, Y., Imanaka, T., Kato, H. J. Biol. Chem. (2004)
- Intermittent claudication in diabetics: treatment with exercise and pentoxifylline--a 6-month, controlled, randomized trial. Belcaro, G., Nicolaides, A.N., Griffin, M., De Sanctis, M.T., Cesarone, M.R., Incandela, L., Ippolito, E., Pomante, P., Geroulakos, G., Ramaswami, G. Angiology. (2002)
- Treatment of venous ulcers with pentoxifylline: a 6-month randomized, double-blind, placebo controlled trial. Belcaro, G., Cesarone, M.R., Nicolaides, A.N., De Sanctis, M.T., Incandela, L., Geroulakos, G. Angiology. (2002)
- Argon versus selective laser trabeculoplasty. Van de Veire, S., Zeyen, T., Stalmans, I. Bulletin de la Société belge d'ophtalmologie. (2006)
- Treatment of retinal vein thrombosis with pentoxifylline: a controlled, randomized trial. De Sanctis, M.T., Cesarone, M.R., Belcaro, G., Incandela, L., Steigerwalt, R., Nicolaides, A.N., Griffin, M., Geroulakos, G. Angiology. (2002)
- Contribution of the endoplasmic reticulum to peroxisome formation. Hoepfner, D., Schildknegt, D., Braakman, I., Philippsen, P., Tabak, H.F. Cell (2005)
- PEX3 functions as a PEX19 docking factor in the import of class I peroxisomal membrane proteins. Fang, Y., Morrell, J.C., Jones, J.M., Gould, S.J. J. Cell Biol. (2004)
- PEX19 is a predominantly cytosolic chaperone and import receptor for class 1 peroxisomal membrane proteins. Jones, J.M., Morrell, J.C., Gould, S.J. J. Cell Biol. (2004)
- Multiple distinct targeting signals in integral peroxisomal membrane proteins. Jones, J.M., Morrell, J.C., Gould, S.J. J. Cell Biol. (2001)
- Function of the PEX19-binding site of human adrenoleukodystrophy protein as targeting motif in man and yeast. PMP targeting is evolutionarily conserved. Halbach, A., Lorenzen, S., Landgraf, C., Volkmer-Engert, R., Erdmann, R., Rottensteiner, H. J. Biol. Chem. (2005)
- Two splice variants of human PEX19 exhibit distinct functions in peroxisomal assembly. Mayerhofer, P.U., Kattenfeld, T., Roscher, A.A., Muntau, A.C. Biochem. Biophys. Res. Commun. (2002)
- Interaction of PEX3 and PEX19 visualized by fluorescence resonance energy transfer (FRET). Muntau, A.C., Roscher, A.A., Kunau, W.H., Dodt, G. Adv. Exp. Med. Biol. (2003)
- Functional domain mapping of peroxin Pex19p: interaction with Pex3p is essential for function and translocation. Matsuzono, Y., Matsuzaki, T., Fujiki, Y. J. Cell. Sci. (2006)
- PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis. Sacksteder, K.A., Jones, J.M., South, S.T., Li, X., Liu, Y., Gould, S.J. J. Cell Biol. (2000)
- Identification of trypanosomatid PEX19: functional characterization reveals impact on cell growth and glycosome size and number. Banerjee, S.K., Kessler, P.S., Saveria, T., Parsons, M. Mol. Biochem. Parasitol. (2005)
- Interaction of a farnesylated protein with renal type IIa Na/Pi co-transporter in response to parathyroid hormone and dietary phosphate. Ito, M., Iidawa, S., Izuka, M., Haito, S., Segawa, H., Kuwahata, M., Ohkido, I., Ohno, H., Miyamoto, K. Biochem. J. (2004)
- Targeting of the tail-anchored peroxisomal membrane proteins PEX26 and PEX15 occurs through C-terminal PEX19-binding sites. Halbach, A., Landgraf, C., Lorenzen, S., Rosenkranz, K., Volkmer-Engert, R., Erdmann, R., Rottensteiner, H. J. Cell. Sci. (2006)
- Pex19p, a farnesylated protein essential for peroxisome biogenesis. Götte, K., Girzalsky, W., Linkert, M., Baumgart, E., Kammerer, S., Kunau, W.H., Erdmann, R. Mol. Cell. Biol. (1998)
- Stress chaperones, mortalin, and pex19p mediate 5-aza-2' deoxycytidine-induced senescence of cancer cells by DNA methylation-independent pathway. Widodo, N., Deocaris, C.C., Kaur, K., Hasan, K., Yaguchi, T., Yamasaki, K., Sugihara, T., Ishii, T., Wadhwa, R., Kaul, S.C. J. Gerontol. A Biol. Sci. Med. Sci. (2007)
- Analysis of human Pex19p's domain structure by pentapeptide scanning mutagenesis. Fransen, M., Vastiau, I., Brees, C., Brys, V., Mannaerts, G.P., Van Veldhoven, P.P. J. Mol. Biol. (2005)
- Targeting elements in the amino-terminal part direct the human 70-kDa peroxisomal integral membrane protein (PMP70) to peroxisomes. Biermanns, M., Gärtner, J. Biochem. Biophys. Res. Commun. (2001)
- Human adrenoleukodystrophy protein and related peroxisomal ABC transporters interact with the peroxisomal assembly protein PEX19p. Gloeckner, C.J., Mayerhofer, P.U., Landgraf, P., Muntau, A.C., Holzinger, A., Gerber, J.K., Kammerer, S., Adamski, J., Roscher, A.A. Biochem. Biophys. Res. Commun. (2000)
- The interaction between human PEX3 and PEX19 characterized by fluorescence resonance energy transfer (FRET) analysis. Muntau, A.C., Roscher, A.A., Kunau, W.H., Dodt, G. Eur. J. Cell Biol. (2003)
- Clinical, biochemical and genetic aspects and neuronal migration in peroxisome biogenesis disorders. Suzuki, Y., Shimozawa, N., Imamura, A., Fukuda, S., Zhang, Z., Orii, T., Kondo, N. J. Inherit. Metab. Dis. (2001)
- Human PEX19: cDNA cloning by functional complementation, mutation analysis in a patient with Zellweger syndrome, and potential role in peroxisomal membrane assembly. Matsuzono, Y., Kinoshita, N., Tamura, S., Shimozawa, N., Hamasaki, M., Ghaedi, K., Wanders, R.J., Suzuki, Y., Kondo, N., Fujiki, Y. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Functional domains and dynamic assembly of the peroxin Pex14p, the entry site of matrix proteins. Itoh, R., Fujiki, Y. J. Biol. Chem. (2006)
- Potential role for Pex19p in assembly of PTS-receptor docking complexes. Fransen, M., Vastiau, I., Brees, C., Brys, V., Mannaerts, G.P., Van Veldhoven, P.P. J. Biol. Chem. (2004)
- Role of Pex19p in the targeting of PMP70 to peroxisome. Kashiwayama, Y., Asahina, K., Shibata, H., Morita, M., Muntau, A.C., Roscher, A.A., Wanders, R.J., Shimozawa, N., Sakaguchi, M., Kato, H., Imanaka, T. Biochim. Biophys. Acta (2005)