The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

ECs0175  -  1-deoxy-D-xylulose 5-phosphate...

Escherichia coli O157:H7 str. Sakai

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of ECs0175


High impact information on ECs0175


Chemical compound and disease context of ECs0175


Biological context of ECs0175


Associations of ECs0175 with chemical compounds


  1. Characterization of 1-deoxy-D-xylulose 5-phosphate reductoisomerase, an enzyme involved in isopentenyl diphosphate biosynthesis, and identification of its catalytic amino acid residues. Kuzuyama, T., Takahashi, S., Takagi, M., Seto, H. J. Biol. Chem. (2000) [Pubmed]
  2. The 1.9 A resolution structure of Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate reductoisomerase, a potential drug target. Henriksson, L.M., Björkelid, C., Mowbray, S.L., Unge, T. Acta Crystallogr. D Biol. Crystallogr. (2006) [Pubmed]
  3. Tools for discovery of inhibitors of the 1-deoxy-D-xylulose 5-phosphate (DXP) synthase and DXP reductoisomerase: an approach with enzymes from the pathogenic bacterium Pseudomonas aeruginosa. Altincicek, B., Hintz, M., Sanderbrand, S., Wiesner, J., Beck, E., Jomaa, H. FEMS Microbiol. Lett. (2000) [Pubmed]
  4. Substrate analogs for the investigation of deoxyxylulose 5-phosphate reductoisomerase inhibition: synthesis and evaluation. Phaosiri, C., Proteau, P.J. Bioorg. Med. Chem. Lett. (2004) [Pubmed]
  5. Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol 4-phosphate synthase (IspC). Implications for the catalytic mechanism and anti-malaria drug development. Steinbacher, S., Kaiser, J., Eisenreich, W., Huber, R., Bacher, A., Rohdich, F. J. Biol. Chem. (2003) [Pubmed]
  6. E. coli MEP synthase: steady-state kinetic analysis and substrate binding. Koppisch, A.T., Fox, D.T., Blagg, B.S., Poulter, C.D. Biochemistry (2002) [Pubmed]
  7. Isolation of the dxr gene of Zymomonas mobilis and characterization of the 1-deoxy-D-xylulose 5-phosphate reductoisomerase. Grolle, S., Bringer-Meyer, S., Sahm, H. FEMS Microbiol. Lett. (2000) [Pubmed]
  8. A mutant pyruvate dehydrogenase E1 subunit allows survival of Escherichia coli strains defective in 1-deoxy-D-xylulose 5-phosphate synthase. Sauret-Güeto, S., Urós, E.M., Ibáñez, E., Boronat, A., Rodríguez-Concepción, M. FEBS Lett. (2006) [Pubmed]
WikiGenes - Universities