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Chemical Compound Review

FR 31564     sodiumN-hydroxy-N-[3- (hydroxy-oxido...

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Disease relevance of fosmidomycin


High impact information on fosmidomycin


Chemical compound and disease context of fosmidomycin


Biological context of fosmidomycin


Anatomical context of fosmidomycin

  • Inhibition of DXR activity by fosmidomycin showed that plastid isoprenoid biosynthesis is required for tomato fruit carotenogenesis but not for other ripening processes [17].

Associations of fosmidomycin with other chemical compounds


Gene context of fosmidomycin


Analytical, diagnostic and therapeutic context of fosmidomycin


  1. Chlamydial histone-DNA interactions are disrupted by a metabolite in the methylerythritol phosphate pathway of isoprenoid biosynthesis. Grieshaber, N.A., Fischer, E.R., Mead, D.J., Dooley, C.A., Hackstadt, T. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  2. Fosmidomycin plus clindamycin for treatment of pediatric patients aged 1 to 14 years with Plasmodium falciparum malaria. Borrmann, S., Lundgren, I., Oyakhirome, S., Impouma, B., Matsiegui, P.B., Adegnika, A.A., Issifou, S., Kun, J.F., Hutchinson, D., Wiesner, J., Jomaa, H., Kremsner, P.G. Antimicrob. Agents Chemother. (2006) [Pubmed]
  3. Fosmidomycin-clindamycin for the treatment of Plasmodium falciparum malaria. Borrmann, S., Issifou, S., Esser, G., Adegnika, A.A., Ramharter, M., Matsiegui, P.B., Oyakhirome, S., Mawili-Mboumba, D.P., Missinou, M.A., Kun, J.F., Jomaa, H., Kremsner, P.G. J. Infect. Dis. (2004) [Pubmed]
  4. In vitro and in vivo antibacterial activity of FR-31564, a phosphonic acid antimicrobial agent. Neu, H.C., Kamimura, T. Antimicrob. Agents Chemother. (1981) [Pubmed]
  5. Synergy of fosmidomycin (FR-31564) and other antimicrobial agents. Neu, H.C., Kamimura, T. Antimicrob. Agents Chemother. (1982) [Pubmed]
  6. Crosstalk between cytosolic and plastidial pathways of isoprenoid biosynthesis in Arabidopsis thaliana. Laule, O., Fürholz, A., Chang, H.S., Zhu, T., Wang, X., Heifetz, P.B., Gruissem, W., Lange, M. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  7. Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol 4-phosphate synthase (IspC). Implications for the catalytic mechanism and anti-malaria drug development. Steinbacher, S., Kaiser, J., Eisenreich, W., Huber, R., Bacher, A., Rohdich, F. J. Biol. Chem. (2003) [Pubmed]
  8. The Arabidopsis csb3 mutant reveals a regulatory link between salicylic acid-mediated disease resistance and the methyl-erythritol 4-phosphate pathway. Gil, M.J., Coego, A., Mauch-Mani, B., Jordá, L., Vera, P. Plant J. (2005) [Pubmed]
  9. The crystal structure of E.coli 1-deoxy-D-xylulose-5-phosphate reductoisomerase in a ternary complex with the antimalarial compound fosmidomycin and NADPH reveals a tight-binding closed enzyme conformation. Mac Sweeney, A., Lange, R., Fernandes, R.P., Schulz, H., Dale, G.E., Douangamath, A., Proteau, P.J., Oefner, C. J. Mol. Biol. (2005) [Pubmed]
  10. Fosfomycin resistance plasmids do not affect fosfomycin transport into Escherichia coli. León, J., García-Lobo, J.M., Ortiz, J.M. Antimicrob. Agents Chemother. (1982) [Pubmed]
  11. A gene cluster for the mevalonate pathway from Streptomyces sp. Strain CL190. Takagi, M., Kuzuyama, T., Takahashi, S., Seto, H. J. Bacteriol. (2000) [Pubmed]
  12. Inhibition of bacterial isoprenoid synthesis by fosmidomycin, a phosphonic acid-containing antibiotic. Shigi, Y. J. Antimicrob. Chemother. (1989) [Pubmed]
  13. 1-Deoxy-D-xylulose 5-phosphate reductoisomerase (IspC) from Mycobacterium tuberculosis: towards understanding mycobacterial resistance to fosmidomycin. Dhiman, R.K., Schaeffer, M.L., Bailey, A.M., Testa, C.A., Scherman, H., Crick, D.C. J. Bacteriol. (2005) [Pubmed]
  14. Cloning of a gene from Escherichia coli that confers resistance to fosmidomycin as a consequence of amplification. Fujisaki, S., Ohnuma, S., Horiuchi, T., Takahashi, I., Tsukui, S., Nishimura, Y., Nishino, T., Kitabatake, M., Inokuchi, H. Gene (1996) [Pubmed]
  15. A fragment-based approach to understanding inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase. Mercklé, L., de Andrés-Gómez, A., Dick, B., Cox, R.J., Godfrey, C.R. Chembiochem (2005) [Pubmed]
  16. Impact of ozone on monoterpene emissions and evidence for an isoprene-like antioxidant action of monoterpenes emitted by Quercus ilex leaves. Loreto, F., Pinelli, P., Manes, F., Kollist, H. Tree Physiol. (2004) [Pubmed]
  17. 1-Deoxy-D-xylulose 5-phosphate reductoisomerase and plastid isoprenoid biosynthesis during tomato fruit ripening. Rodríguez-Concepción, M., Ahumada, I., Diez-Juez, E., Sauret-Güeto, S., Lois, L.M., Gallego, F., Carretero-Paulet, L., Campos, N., Boronat, A. Plant J. (2001) [Pubmed]
  18. 13C labeling reveals chloroplastic and extrachloroplastic pools of dimethylallyl pyrophosphate and their contribution to isoprene formation. Loreto, F., Pinelli, P., Brancaleoni, E., Ciccioli, P. Plant Physiol. (2004) [Pubmed]
  19. In vitro and in vivo synergy of fosmidomycin, a novel antimalarial drug, with clindamycin. Wiesner, J., Henschker, D., Hutchinson, D.B., Beck, E., Jomaa, H. Antimicrob. Agents Chemother. (2002) [Pubmed]
  20. Synthesis and biological evaluation of cyclopropyl analogues of fosmidomycin as potent Plasmodium falciparum growth inhibitors. Devreux, V., Wiesner, J., Goeman, J.L., Van der Eycken, J., Jomaa, H., Van Calenbergh, S. J. Med. Chem. (2006) [Pubmed]
  21. Enhanced flux through the methylerythritol 4-phosphate pathway in Arabidopsis plants overexpressing deoxyxylulose 5-phosphate reductoisomerase. Carretero-Paulet, L., Cair??, A., Botella-Pav??a, P., Besumbes, O., Campos, N., Boronat, A., Rodr??guez-Concepci??n, M. Plant Mol. Biol. (2006) [Pubmed]
  22. Fosmidomycin resistance in adenylate cyclase deficient (cya) mutants of Escherichia coli. Sakamoto, Y., Furukawa, S., Ogihara, H., Yamasaki, M. Biosci. Biotechnol. Biochem. (2003) [Pubmed]
  23. Cloning and heterologous expression of a cDNA encoding 1-deoxy-D-xylulose-5-phosphate reductoisomerase of Arabidopsis thaliana. Schwender, J., Müller, C., Zeidler, J., Lichtenthaler, H.K. FEBS Lett. (1999) [Pubmed]
  24. AFMoC enhances predictivity of 3D QSAR: a case study with DOXP-reductoisomerase. Silber, K., Heidler, P., Kurz, T., Klebe, G. J. Med. Chem. (2005) [Pubmed]
  25. Pharmacokinetics of fosmidomycin, a new phosphonic acid antibiotic. Murakawa, T., Sakamoto, H., Fukada, S., Konishi, T., Nishida, M. Antimicrob. Agents Chemother. (1982) [Pubmed]
  26. Activity of fosmidomycin in an in vitro model of the treatment of bacterial cystitis. Kanimoto, Y., Greenwood, D. Infection (1987) [Pubmed]
  27. Bioassay for determination of fosmidomycin in plasma and urine: Application for pharmacokinetic dose optimisation. Cheoymang, A., Hudchinton, D., Kioy, D., Na-Bangchang, K. J. Microbiol. Methods (2007) [Pubmed]
  28. Determination of fosmidomycin in human serum and urine by capillary electrophoresis. Bronner, S., Renault, C., Hintz, M., Wiesner, J., Jomaa, H., Monteil, H., Jehl, F. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (2004) [Pubmed]
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