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Gene Review

ECs5026  -  LexA repressor

Escherichia coli O157:H7 str. Sakai

 
 
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Disease relevance of ECs5026

  • The Escherichia coli LexA repressor-operator system works in mammalian cells [1].
  • Considerable homology has also been detected between UmuD, MucA, and the COOH-terminal domains of the LexA repressor and the repressors of phage lambda, 434, and P22 [2].
  • To investigate integration site selection, and to possibly influence this process, we have used a model system in which the avian sarcoma virus (ASV) IN, and segments thereof, have been fused to the Escherichia coli LexA repressor protein DNA binding domain (DBD) [3].
 

High impact information on ECs5026

 

Chemical compound and disease context of ECs5026

 

Biological context of ECs5026

References

  1. The Escherichia coli LexA repressor-operator system works in mammalian cells. Smith, G.M., Mileham, K.A., Cooke, S.E., Woolston, S.J., George, H.K., Charles, A.D., Brammar, W.J. EMBO J. (1988) [Pubmed]
  2. umuDC and mucAB operons whose products are required for UV light- and chemical-induced mutagenesis: UmuD, MucA, and LexA proteins share homology. Perry, K.L., Elledge, S.J., Mitchell, B.B., Marsh, L., Walker, G.C. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  3. Targeting of retroviral integrase by fusion to a heterologous DNA binding domain: in vitro activities and incorporation of a fusion protein into viral particles. Katz, R.A., Merkel, G., Skalka, A.M. Virology (1996) [Pubmed]
  4. Signal transduction and transcriptional regulation by glucocorticoid receptor-LexA fusion proteins. Godowski, P.J., Picard, D., Yamamoto, K.R. Science (1988) [Pubmed]
  5. SOS-inducible DNA repair proteins, RuvA and RuvB, of Escherichia coli: functional interactions between RuvA and RuvB for ATP hydrolysis and renaturation of the cruciform structure in supercoiled DNA. Shiba, T., Iwasaki, H., Nakata, A., Shinagawa, H. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  6. C-terminal truncated Escherichia coli RecA protein RecA5327 has enhanced binding affinities to single- and double-stranded DNAs. Tateishi, S., Horii, T., Ogawa, T., Ogawa, H. J. Mol. Biol. (1992) [Pubmed]
  7. SOS induction in Escherichia coli by single-stranded DNA of mutant filamentous phage: monitoring by cleavage of LexA repressor. Higashitani, N., Higashitani, A., Horiuchi, K. J. Bacteriol. (1995) [Pubmed]
  8. Evidence that UV-inducible error-prone repair is absent in Haemophilus influenzae Rd, with a discussion of the relation to error-prone repair of alkylating-agent damage. Kimball, R.F., Boling, M.E., Perdue, S.W. Mutat. Res. (1977) [Pubmed]
  9. The role of electrostatic interactions in the mechanism of peptide bond hydrolysis by a Ser-Lys catalytic dyad. Slilaty, S.N., Vu, H.K. Protein Eng. (1991) [Pubmed]
  10. Structure and regulation of the Escherichia coli ruv operon involved in DNA repair and recombination. Shinagawa, H., Makino, K., Amemura, M., Kimura, S., Iwasaki, H., Nakata, A. J. Bacteriol. (1988) [Pubmed]
  11. Coupling of DNA replication and cell division: sulB is an allele of ftsZ. Lutkenhaus, J.F. J. Bacteriol. (1983) [Pubmed]
  12. Induction of only one SOS operon, umuDC, is required for SOS mutagenesis in Escherichia coli. Sommer, S., Knezevic, J., Bailone, A., Devoret, R. Mol. Gen. Genet. (1993) [Pubmed]
  13. Partial suppression of the LexA phenotype by mutations (rnm) which restore ultraviolet resistance but not ultraviolet mutability to Escherichia coli B/r uvr A lexA. Volkert, M.R., George, D.L., Witkin, E.M. Mutat. Res. (1976) [Pubmed]
  14. Indirect and intragenic suppression of the lexA102 mutation in E. coli B/r. Volkert, M.R., Spencer, D.F., Clark, A.J. Mol. Gen. Genet. (1979) [Pubmed]
 
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