Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

ACY3 - aspartoacylase (aminocyclase) 3

Homo sapiens

Synonyms: ACY-3, ASPA2, Acylase III, Aminoacylase-3, Aspartoacylase-2, ...

Hwang, H. et al., Nuutinen, S. et al., Yashima, M. et al., Kukkonen, J.V. et al., Kukkonen, J.V. et al., et al.

Xu, Dawson, Tao, Li, Cao,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of ACY3

Body weight was not significantly affected by HCBP except during the 4th instar [1].
5. These results suggest that HCBP originates from beta-lipoprotein, and beta-lipoprotein may have an important role in cholesterol accumulation on radicular cysts [2].

High impact information on ACY3

This study determined desorption rates of four laboratory spiked compounds, benzo[a]pyrene (BaP), 2,4,5,2',4',5'-hexachlorobiphenyl (HCBP), 3,4,3',4'-tetrachlorobiphenyl (TCBP), and pyrene (PY), to evaluate the effect of sediment characteristics [3].
Bioaccumulation experiments were performed with Lumbriculus variegatus and Diporeia species exposed in seven sediments dosed with 2,4,5,2',4',5'-hexachlorobiphenyl (HCBP) and benzo[a]pyrene (BaP) or pyrene (PY) and 3,4,3',4'-tetrachlorobiphenyl (TCBP) [4].
Uptake, biotransformation, and elimination rates were determined for pentachlorophenol (PCP), methyl parathion (MP), fluoranthene (FU), and 2,2',4,4',5,5'-hexachlorobiphenyl (HCBP) using juvenile Hyalella azteca under water-only exposures [5].
The uptake clearance coefficients (k(u)) were 25.7 +/- 2.9, 11.5 +/- 1.1, 184.4 +/- 9.3, and 251.7 +/- 9.0 (ml g(-1) h(-1)) for PCP, MP, FU, and HCBP, respectively [5].
For low doses of Cu, oil, atrazine, HCBP, and hexazinone, exergy and structural exergy were either unchanged or only slightly changed, suggesting that the lake ecosystems were not significantly impacted by these chemical stressors [6].

Biological context of ACY3

Identifying body residues of HCBP associated with 10-d mortality and partial life cycle effects in the midge, Chironomus riparius [1].

Associations of ACY3 with chemical compounds

The relationship between the body residue of 2,2',4,4',5,5'-hexachlorobiphenyl (HCBP) and its effects, including 10-d mortality and chronic sublethal effects on the midge, Chironomus riparius, are examined in a partial life cycle assessment [1].
2. Relationship between the amounts of apo B and free cholesterol or activity of heat-stable cholesterol-binding protein (HCBP) were examined [2].

Analytical, diagnostic and therapeutic context of ACY3

HCBP is a gamma-globulin of restricted electrophoretic heterogeneity as shown by immunoelectrophoresis [7].

References

Identifying body residues of HCBP associated with 10-d mortality and partial life cycle effects in the midge, Chironomus riparius. Hwang, H., Fisher, S.W., Landrum, P.F. Aquat. Toxicol. (2001) [Pubmed]
Studies on cholesterol accumulation in radicular cyst fluid--origin of heat-stable cholesterol-binding protein. Yashima, M., Ogura, N., Abiko, Y. Int. J. Biochem. (1990) [Pubmed]
Sediment characteristics affecting desorption kinetics of select PAH and PCB congeners for seven laboratory spiked sediments. Kukkonen, J.V., Landrum, P.F., Mitra, S., Gossiaux, D.C., Gunnarsson, J., Weston, D. Environ. Sci. Technol. (2003) [Pubmed]
The contrasting roles of sedimentary plant-derived carbon and black carbon on sediment-spiked hydrophobic organic contaminant bioavailability to Diporeia species and Lumbriculus variegatus. Kukkonen, J.V., Mitra, S., Landrum, P.F., Gossiaux, D.C., Gunnarsson, J., Weston, D. Environ. Toxicol. Chem. (2005) [Pubmed]
Toxicokinetics of organic contaminants in Hyalella azteca. Nuutinen, S., Landrum, P.F., Schuler, L.J., Kukkonen, J.V., Lydy, M.J. Arch. Environ. Contam. Toxicol. (2003) [Pubmed]
System-level responses of lake ecosystems to chemical stresses using exergy and structural exergy as ecological indicators. Xu, F.L., Dawson, R.W., Tao, S., Li, B.G., Cao, J. Chemosphere (2002) [Pubmed]
Carcinoembryonic antigen-binding immunoglobulin isolated from normal human serum by affinity chromatography. Pressman, D., Chu, T.M., Grossberg, A.L. J. Natl. Cancer Inst. (1979) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

acy3.1	Danio rerio
acy3.2	Danio rerio
ACY3	Macaca mulatta
Acy3	Mus musculus
ACY3	Pan troglodytes
Acy3	Rattus norvegicus
acy3	Xenopus (Silurana) tropicalis

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.