The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

CYP17A1  -  cytochrome P450, family 17, subfamily A,...

Homo sapiens

Synonyms: 17-alpha-hydroxyprogesterone aldolase, CPT7, CYP17, CYPXVII, Cytochrome P450 17A1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of CYP17A1


High impact information on CYP17A1


Chemical compound and disease context of CYP17A1


Biological context of CYP17A1


Anatomical context of CYP17A1

  • Aldosterone synthase (CYP11B2) messenger ribonucleic acid was detected in the aorta and fetal heart, but not in any region of the adult heart, and 17alpha-hydroxylase (CYP17) was not detected in any cardiac sample [16].
  • Adrenocorticotropin/cyclic adenosine 3',5'-monophosphate-mediated transcription of the human CYP17 gene in the adrenal cortex is dependent on phosphatase activity [15].
  • Thus, specific set of genetic polymorphisms (carrying of CYP17 A1 allele and combination of longest A6 or A7 CYP19 alleles) may predispose to the induction of higher rate of local estrogen biosynthesis in malignant endometrium, that in its turn may support growth of the latter [17].
  • The male baby born of this pregnancy had normal genitalia but showed a urinary steroid profile indicating partial deficiencies of P450c17 and P450c21 [18].
  • Since high 17,20-lyase activity is required for the production of androgens in the testis, we wanted to determine the importance of this second cDNA in the modulation of P450c17 17,20-lyase activity and hence, its role in the formation of active androgens [19].

Associations of CYP17A1 with chemical compounds


Physical interactions of CYP17A1


Enzymatic interactions of CYP17A1

  • 3. Human steroidogenic CYP17 also catalysed aminopyrine N-demethylation and the activity was comparable with that for CYP3A4 which is a dominant P450 in human liver [10].
  • Like the pig CYP17, the human CYP17 also catalysed the cytochrome b5-dependent direct cleavage of pregnenolone into the delta 5,16-steroid, but unlike it the human enzyme did not cleave progesterone at all [28].

Regulatory relationships of CYP17A1


Other interactions of CYP17A1

  • CYP17 (P = 0.05) and TP53 (P = 0.06) polymorphisms showed marginally significant associations in unstratified analyses [34].
  • CAMP-dependent protein kinase enhances CYP17 transcription via MKP-1 activation in H295R human adrenocortical cells [35].
  • We found no significant associations between breast density and the variant alleles for CYP1A1, CYP1B1 and CYP17 [36].
  • Transcriptional activation of human CYP17 in H295R adrenocortical cells depends on complex formation among p54(nrb)/NonO, protein-associated splicing factor, and SF-1, a complex that also participates in repression of transcription [37].
  • In summary, our studies demonstrate a role for sphingolipid metabolism and SREBP1 in ACTH-dependent CYP17 regulation and steroidogenesis [29].

Analytical, diagnostic and therapeutic context of CYP17A1


  1. Profiling genetic variation along the androgen biosynthesis and metabolism pathways implicates several single nucleotide polymorphisms and their combinations as prostate cancer risk factors. Mononen, N., Seppälä, E.H., Duggal, P., Autio, V., Ikonen, T., Ellonen, P., Saharinen, J., Saarela, J., Vihinen, M., Tammela, T.L., Kallioniemi, O., Bailey-Wilson, J.E., Schleutker, J. Cancer Res. (2006) [Pubmed]
  2. Variants in Estrogen Biosynthesis Genes, Sex Steroid Hormone Levels, and Endometrial Cancer: A HuGE Review. Olson, S.H., Bandera, E.V., Orlow, I. Am. J. Epidemiol. (2007) [Pubmed]
  3. Polymorphisms and haplotypes in the cytochrome P450 17A1, prolactin, and catechol-O-methyltransferase genes and non-Hodgkin lymphoma risk. Skibola, C.F., Bracci, P.M., Paynter, R.A., Forrest, M.S., Agana, L., Woodage, T., Guegler, K., Smith, M.T., Holly, E.A. Cancer Epidemiol. Biomarkers Prev. (2005) [Pubmed]
  4. Polymorphisms in cytochrome P450 17A1 and risk of non-Hodgkin lymphoma. Skibola, C.F., Lightfoot, T., Agana, L., Smith, A., Rollinson, S., Kao, A., Adamson, P., Morgan, G.J., Smith, M.T., Roman, E. Br. J. Haematol. (2005) [Pubmed]
  5. Functional maternal catechol-O-methyltransferase polymorphism and fetal growth restriction. Sata, F., Yamada, H., Suzuki, K., Saijo, Y., Yamada, T., Minakami, H., Kishi, R. Pharmacogenet. Genomics (2006) [Pubmed]
  6. Cytochrome P450 17A1 and catechol O-methyltransferase polymorphisms and age at Lynch syndrome colon cancer onset in Newfoundland. Campbell, P.T., Edwards, L., McLaughlin, J.R., Green, J., Younghusband, H.B., Woods, M.O. Clin. Cancer Res. (2007) [Pubmed]
  7. The genetic and functional basis of isolated 17,20-lyase deficiency. Geller, D.H., Auchus, R.J., Mendonça, B.B., Miller, W.L. Nat. Genet. (1997) [Pubmed]
  8. Decreases in ovarian cytochrome P450c17 alpha activity and serum free testosterone after reduction of insulin secretion in polycystic ovary syndrome. Nestler, J.E., Jakubowicz, D.J. N. Engl. J. Med. (1996) [Pubmed]
  9. Genetic modeling of estrogen metabolism as a risk factor of hormone-dependent disorders. Huber, J.C., Schneeberger, C., Tempfer, C.B. Maturitas. (2002) [Pubmed]
  10. Contribution of human hepatic cytochrome P450s and steroidogenic CYP17 to the N-demethylation of aminopyrine. Niwa, T., Sato, R., Yabusaki, Y., Ishibashi, F., Katagiri, M. Xenobiotica (1999) [Pubmed]
  11. Molecular genetics of congenital adrenal hyperplasia. White, P.C., New, M.I. Baillieres Clin. Endocrinol. Metab. (1988) [Pubmed]
  12. Biological oxidations and P450 reactions. Recombinant mouse CYP1B1 expressed in Escherichia coli exhibits selective binding by polycyclic hydrocarbons and metabolism which parallels C3H10T1/2 cell microsomes, but differs from human recombinant CYP1B1. Savas, U., Carstens, C.P., Jefcoate, C.R. Arch. Biochem. Biophys. (1997) [Pubmed]
  13. Association of polymorphisms in CYP17A1, MTP, and VLDLR with bone mineral density in community-dwelling Japanese women and men. Yamada, Y., Ando, F., Shimokata, H. Genomics (2005) [Pubmed]
  14. Polymorphisms in the P450 c17 (17-hydroxylase/17,20-Lyase) and P450 c19 (aromatase) genes: association with serum sex steroid concentrations and bone mineral density in postmenopausal women. Somner, J., McLellan, S., Cheung, J., Mak, Y.T., Frost, M.L., Knapp, K.M., Wierzbicki, A.S., Wheeler, M., Fogelman, I., Ralston, S.H., Hampson, G.N. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  15. Adrenocorticotropin/cyclic adenosine 3',5'-monophosphate-mediated transcription of the human CYP17 gene in the adrenal cortex is dependent on phosphatase activity. Sewer, M.B., Waterman, M.R. Endocrinology (2002) [Pubmed]
  16. Steroidogenic enzyme gene expression in the human heart. Kayes-Wandover, K.M., White, P.C. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  17. CYP17 and CYP19 genetic polymorphisms in endometrial cancer: association with intratumoral aromatase activity. Berstein, L.M., Imyanitov, E.N., Kovalevskij, A.J., Maximov, S.J., Vasilyev, D.A., Buslov, K.G., Sokolenko, A.P., Iyevleva, A.G., Chekmariova, E.V., Thijssen, J.H. Cancer Lett. (2004) [Pubmed]
  18. Prenatal diagnosis of P450 oxidoreductase deficiency (ORD): a disorder causing low pregnancy estriol, maternal and fetal virilization, and the Antley-Bixler syndrome phenotype. Shackleton, C., Marcos, J., Arlt, W., Hauffa, B.P. Am. J. Med. Genet. A (2004) [Pubmed]
  19. Assessment of the ability of type 2 cytochrome b5 to modulate 17,20-lyase activity of human P450c17. Soucy, P., Luu-The, V. J. Steroid Biochem. Mol. Biol. (2002) [Pubmed]
  20. Urine steroid hormone profile analysis in cytochrome P450 oxidoreductase deficiency: implication for the backdoor pathway to dihydrotestosterone. Homma, K., Hasegawa, T., Nagai, T., Adachi, M., Horikawa, R., Fujiwara, I., Tajima, T., Takeda, R., Fukami, M., Ogata, T. J. Clin. Endocrinol. Metab. (2006) [Pubmed]
  21. Cytochrome P450 oxidoreductase gene mutations and Antley-Bixler syndrome with abnormal genitalia and/or impaired steroidogenesis: molecular and clinical studies in 10 patients. Fukami, M., Horikawa, R., Nagai, T., Tanaka, T., Naiki, Y., Sato, N., Okuyama, T., Nakai, H., Soneda, S., Tachibana, K., Matsuo, N., Sato, S., Homma, K., Nishimura, G., Hasegawa, T., Ogata, T. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  22. Estrogen receptor-alpha mediates an intraovarian negative feedback loop on thecal cell steroidogenesis via modulation of Cyp17a1 (cytochrome P450, steroid 17alpha-hydroxylase/17,20 lyase) expression. Taniguchi, F., Couse, J.F., Rodriguez, K.F., Emmen, J.M., Poirier, D., Korach, K.S. FASEB J. (2007) [Pubmed]
  23. Estrogen-metabolizing gene polymorphisms, but not estrogen receptor-alpha gene polymorphisms, are associated with the onset of menarche in healthy postmenopausal Japanese women. Gorai, I., Tanaka, K., Inada, M., Morinaga, H., Uchiyama, Y., Kikuchi, R., Chaki, O., Hirahara, F. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  24. Association of CYP17, CYP19, CYP1B1, and COMT polymorphisms with serum and urinary sex hormone concentrations in postmenopausal women. Tworoger, S.S., Chubak, J., Aiello, E.J., Ulrich, C.M., Atkinson, C., Potter, J.D., Yasui, Y., Stapleton, P.L., Lampe, J.W., Farin, F.M., Stanczyk, F.Z., McTiernan, A. Cancer Epidemiol. Biomarkers Prev. (2004) [Pubmed]
  25. Coregulator Exchange and Sphingosine-Sensitive Cooperativity of Steroidogenic Factor-1, General Control Nonderepressed 5, p54, and p160 Coactivators Regulate Cyclic Adenosine 3',5'-Monophosphate-Dependent Cytochrome P450c17 Transcription Rate. Dammer, E.B., Leon, A., Sewer, M.B. Mol. Endocrinol. (2007) [Pubmed]
  26. Lysine mutagenesis identifies cationic charges of human CYP17 that interact with cytochrome b5 to promote male sex-hormone biosynthesis. Lee-Robichaud, P., Akhtar, M.E., Akhtar, M. Biochem. J. (1999) [Pubmed]
  27. Corticotropin-releasing hormone stimulates P450 17alpha-hydroxylase/17,20-lyase in human fetal adrenal cells via protein kinase C. Chakravorty, A., Mesiano, S., Jaffe, R.B. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
  28. Modulation of the activity of human 17 alpha-hydroxylase-17,20-lyase (CYP17) by cytochrome b5: endocrinological and mechanistic implications. Lee-Robichaud, P., Wright, J.N., Akhtar, M.E., Akhtar, M. Biochem. J. (1995) [Pubmed]
  29. Cyclic adenosine 5'-monophosphate-dependent sphingosine-1-phosphate biosynthesis induces human CYP17 gene transcription by activating cleavage of sterol regulatory element binding protein 1. Ozbay, T., Rowan, A., Leon, A., Patel, P., Sewer, M.B. Endocrinology (2006) [Pubmed]
  30. Adenovirus-delivered DKK3/WNT4 and Steroidogenesis in Primary Cultures of Adrenocortical Cells. Chen, M., Hornsby, P.J. Horm. Metab. Res. (2006) [Pubmed]
  31. The relationship between a polymorphism in CYP17 with plasma hormone levels and prostate cancer. Haiman, C.A., Stampfer, M.J., Giovannucci, E., Ma, J., Decalo, N.E., Kantoff, P.W., Hunter, D.J. Cancer Epidemiol. Biomarkers Prev. (2001) [Pubmed]
  32. Metabolism and interaction of bisphenol A in human hepatic cytochrome P450 and steroidogenic CYP17. Niwa, T., Fujimoto, M., Kishimoto, K., Yabusaki, Y., Ishibashi, F., Katagiri, M. Biol. Pharm. Bull. (2001) [Pubmed]
  33. The primate adrenal zona reticularis is defined by expression of cytochrome b5, 17alpha-hydroxylase/17,20-lyase cytochrome P450 (P450c17) and NADPH-cytochrome P450 reductase (reductase) but not 3beta-hydroxysteroid dehydrogenase/delta5-4 isomerase (3beta-HSD). Mapes, S., Corbin, C.J., Tarantal, A., Conley, A. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
  34. Effect of germ-line genetic variation on breast cancer survival in a population-based study. Goode, E.L., Dunning, A.M., Kuschel, B., Healey, C.S., Day, N.E., Ponder, B.A., Easton, D.F., Pharoah, P.P. Cancer Res. (2002) [Pubmed]
  35. CAMP-dependent protein kinase enhances CYP17 transcription via MKP-1 activation in H295R human adrenocortical cells. Sewer, M.B., Waterman, M.R. J. Biol. Chem. (2003) [Pubmed]
  36. An investigation of mammographic density and gene variants in healthy women. Maskarinec, G., Lurie, G., Williams, A.E., Le Marchand, L. Int. J. Cancer (2004) [Pubmed]
  37. Transcriptional activation of human CYP17 in H295R adrenocortical cells depends on complex formation among p54(nrb)/NonO, protein-associated splicing factor, and SF-1, a complex that also participates in repression of transcription. Sewer, M.B., Nguyen, V.Q., Huang, C.J., Tucker, P.W., Kagawa, N., Waterman, M.R. Endocrinology (2002) [Pubmed]
  38. A model for predicting age at menopause in white women. Hefler, L.A., Grimm, C., Bentz, E.K., Reinthaller, A., Heinze, G., Tempfer, C.B. Fertil. Steril. (2006) [Pubmed]
  39. Two single nucleotide polymorphisms in the CYP17 and COMT Genes--relation to bone mass and longitudinal bone changes in postmenopausal women with or without hormone replacement therapy. The Danish Osteoporosis Prevention Study. Tofteng, C.L., Abrahamsen, B., Jensen, J.E., Petersen, S., Teilmann, J., Kindmark, A., Vestergaard, P., Gram, J., Langdahl, B.L., Mosekilde, L. Calcif. Tissue Int. (2004) [Pubmed]
  40. Mutagenesis of putative serine-threonine phosphorylation sites proximal to Arg255 of human cytochrome P450c17 does not selectively promote its 17,20-lyase activity. Souter, I., Munir, I., Mallick, P., Weitsman, S.R., Geller, D.H., Magoffin, D.A. Fertil. Steril. (2006) [Pubmed]
WikiGenes - Universities