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Gene Review

CACNA2D2  -  calcium channel, voltage-dependent, alpha...

Homo sapiens

Synonyms: KIAA0558, Voltage-dependent calcium channel subunit alpha-2/delta-2, Voltage-gated calcium channel subunit alpha-2/delta-2
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Disease relevance of CACNA2D2


High impact information on CACNA2D2


Biological context of CACNA2D2


Associations of CACNA2D2 with chemical compounds

  • Together, these results suggest that one of the pathways in CACNA2D2-induced apoptosis is mediated through disruption of mitochondria membrane integrity, the release of cyt c, and the activation of caspases, a process that is associated with regulation of cytosolic free Ca(2+) contents [2].


  1. Functional properties of a new voltage-dependent calcium channel alpha(2)delta auxiliary subunit gene (CACNA2D2). Gao, B., Sekido, Y., Maximov, A., Saad, M., Forgacs, E., Latif, F., Wei, M.H., Lerman, M., Lee, J.H., Perez-Reyes, E., Bezprozvanny, I., Minna, J.D. J. Biol. Chem. (2000) [Pubmed]
  2. CACNA2D2-mediated apoptosis in NSCLC cells is associated with alterations of the intracellular calcium signaling and disruption of mitochondria membrane integrity. Carboni, G.L., Gao, B., Nishizaki, M., Xu, K., Minna, J.D., Roth, J.A., Ji, L. Oncogene (2003) [Pubmed]
  3. Cerebellar ataxia, seizures, premature death, and cardiac abnormalities in mice with targeted disruption of the Cacna2d2 gene. Ivanov, S.V., Ward, J.M., Tessarollo, L., McAreavey, D., Sachdev, V., Fananapazir, L., Banks, M.K., Morris, N., Djurickovic, D., Devor-Henneman, D.E., Wei, M.H., Alvord, G.W., Gao, B., Richardson, J.A., Minna, J.D., Rogawski, M.A., Lerman, M.I. Am. J. Pathol. (2004) [Pubmed]
  4. Discovery of frequent homozygous deletions in chromosome 3p21.3 LUCA and AP20 regions in renal, lung and breast carcinomas. Senchenko, V.N., Liu, J., Loginov, W., Bazov, I., Angeloni, D., Seryogin, Y., Ermilova, V., Kazubskaya, T., Garkavtseva, R., Zabarovska, V.I., Kashuba, V.I., Kisselev, L.L., Minna, J.D., Lerman, M.I., Klein, G., Braga, E.A., Zabarovsky, E.R. Oncogene (2004) [Pubmed]
  5. A G-to-A single nucleotide polymorphism in intron 2 of the human CACNA2D2 gene that maps at 3p21.3. Angeloni, D., Duh, F.M., Wei, M.F., Johnson, B.E., Lerman, M.I. Mol. Cell. Probes (2001) [Pubmed]
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