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Gene Review

SNORD25  -  small nucleolar RNA, C/D box 25

Homo sapiens

Synonyms: RNU25, U25
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Disease relevance of SNORD25

  • Metal ion-induced changes in HIV-1 TAR RNA internal dynamics were determined by the changes in EPR spectral width for TAR RNAs containing spin-labeled nucleotides (U23, U25, U38, and U40) [1].
  • The cytotoxicity was measured in MTT tests using the cisplatin resistant human U25 1 malignant glioma cell line as a model [2].

High impact information on SNORD25

  • Depletion of U25 from the Xenopus oocyte abolished 2'-O-methylation of G1448 in 18S rRNA; methylation could be restored by injecting either the Xenopus or human U25 transcript into U25-depleted oocytes [3].
  • TAR RNAs containing single nitroxide spin-labels in the 2'-position of U23, U25, U38, or U40 were incubated with compounds known to inhibit TAR-Tat complex formation [4].
  • Mg(2+), Co(2+), Ni(2+), Zn(2+), and Ba(2+) had similar effects on U23, U38, and U40, but the mobility of U25 was markedly increased [1].
  • While Li(+) and K(+) had little effect on TAR RNA internal dynamics, Na(+) unexpectedly had a dynamic signature that was similar to Ca(2+) and Sr(2+), with a decrease in mobility at U23 and U38, little or no change at U25, and an increase in mobility at U40 [1].
  • DNA binding, cellular penetration, and cytotoxicity were compared in three human glioma cell lines (T98G, U87-MG, and U25 IN) and a human fibroblast cell strain (HS 68) [5].

Chemical compound and disease context of SNORD25


  1. EPR spectroscopic analysis of TAR RNA-metal ion interactions. Edwards, T.E., Sigurdsson, S.T. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  2. Rational design of platinum chemotherapeutic drugs: hydrophobicity increases cytotoxicity. Moeller, N., Kangarloo, B.S., Puscasu, I., Mock, C., Krebs, B., Wolff, J.E. Anticancer Res. (2000) [Pubmed]
  3. A small nucleolar RNA requirement for site-specific ribose methylation of rRNA in Xenopus. Tycowski, K.T., Smith, C.M., Shu, M.D., Steitz, J.A. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  4. Electron paramagnetic resonance dynamic signatures of TAR RNA-small molecule complexes provide insight into RNA structure and recognition. Edwards, T.E., Sigurdsson, S.T. Biochemistry (2002) [Pubmed]
  5. Cellular accumulation determines the activity of three novel tricyclic platinum agents. Gangopadhyay, S.B., Roendigs, A., Kangarloo, S.B., Krebs, B., Wolff, J.E. Anticancer Res. (2001) [Pubmed]
  6. Tamoxifen interacts with NEU/C-ERBB-2 receptor and inhibits growth of human malignant glioma cell lines. Liu, Z., Kokunai, T., Tamaki, N. The Kobe journal of medical sciences. (2001) [Pubmed]
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