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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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About

Terms

 

Gene Review: 

ACPT  -  acid phosphatase, testicular

Homo sapiens

Synonyms: Testicular acid phosphatase
 
 
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Disease relevance of ACPT

  • Increasing severity of obstructive sleep apnea (OSA) or sleep disturbance was associated with daytime inactivity/sleepiness and autistic-relating behavior (DBC) and with impulsiveness (ACPT) [1].
 

Psychiatry related information on ACPT

  • Examination of right frontal and parietal cortex ACPT task substrates revealed decreased parietal blood flow in PTSD-SA, which may represent a pathophysiology for poor attentional task performance in PTSD-SA [2].
  • The test battery included the Auditory Continuous Performance Test (ACPT), SCAN (a screening test for auditory processing disorders in children), and the Token Test for Children. Results indicated that there was significant improvement in the children's performance on all measures when on methylphenidate [3].
  • This study investigated the effect of variable interstimulus intervals (ISIs) on behavioral reaction time (RT) and on the latency and amplitude of the auditory P300 using an auditory continuous performance task (ACPT) paradigm [4].
 

High impact information on ACPT

  • None of the ACPT isomers showed a significant effect on ionotropic NMDA, KA, and AMPA receptors [5].
  • We have cloned a new human acid phosphatase gene (named testicular acid phosphatase, ACPT), which is expressed mainly in testis and to a lower extent in the prostate, trachea, and other tissues [6].
  • ACPT test was used for quantitative assessment of A beta, A sigma, and C fiber transmission, which are associated with pain, by three (2000, 250, and 5 Hz) different frequencies of electric stimulation [7].
  • Positron emission tomography (PET) scans with 15O-butanol were used to compare regional cerebral blood flow (rCBF) between the groups during rest and during an auditory continuous performance task (ACPT) [8].
  • CA-PTSD patients had significantly higher rCBF in right amygdala and left parahippocampal gyrus than normals during the ACPT [8].
 

Associations of ACPT with chemical compounds

  • However, ACPT performance was significantly better (p < .000) for the Ritalin versus placebo condition [9].
 

Other interactions of ACPT

 

Analytical, diagnostic and therapeutic context of ACPT

References

  1. Sleep-disordered breathing in Prader-Willi syndrome and its association with neurobehavioral abnormalities. O'Donoghue, F.J., Camfferman, D., Kennedy, J.D., Martin, A.J., Couper, T., Lack, L.D., Lushington, K., McEvoy, R.D. J. Pediatr. (2005) [Pubmed]
  2. Attention and regional cerebral blood flow in posttraumatic stress disorder patients with substance abuse histories. Semple, W.E., Goyer, P.F., McCormick, R., Compton-Toth, B., Morris, E., Donovan, B., Muswick, G., Nelson, D., Garnett, M.L., Sharkoff, J., Leisure, G., Miraldi, F., Schulz, S.C. Psychiatry research. (1996) [Pubmed]
  3. Effects of methylphenidate on the auditory processing abilities of children with attention deficit-hyperactivity disorder. Keith, R.W., Engineer, P. Journal of learning disabilities. (1991) [Pubmed]
  4. Interactions among variables in the P300 response to a continuous performance task. Salamat, M.T., McPherson, D.L. Journal of the American Academy of Audiology. (1999) [Pubmed]
  5. Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes. Acher, F.C., Tellier, F.J., Azerad, R., Brabet, I.N., Fagni, L., Pin, J.P. J. Med. Chem. (1997) [Pubmed]
  6. Molecular cloning of a novel human acid phosphatase gene (ACPT) that is highly expressed in the testis. Yousef, G.M., Diamandis, M., Jung, K., Diamandis, E.P. Genomics (2001) [Pubmed]
  7. Current perception thresholds of patients with long-term administration of maprotiline. Kudoh, A., Katagai, H., Takazawa, T. Pharmacopsychiatry (2003) [Pubmed]
  8. Higher brain blood flow at amygdala and lower frontal cortex blood flow in PTSD patients with comorbid cocaine and alcohol abuse compared with normals. Semple, W.E., Goyer, P.F., McCormick, R., Donovan, B., Muzic, R.F., Rugle, L., McCutcheon, K., Lewis, C., Liebling, D., Kowaliw, S., Vapenik, K., Semple, M.A., Flener, C.R., Schulz, S.C. Psychiatry. (2000) [Pubmed]
  9. Effects of methylphenidate (Ritalin) on auditory performance in children with attention and auditory processing disorders. Tillery, K.L., Katz, J., Keller, W.D. J. Speech Lang. Hear. Res. (2000) [Pubmed]
  10. Validity of the Auditory Continuous Performance Test in differentiating central processing auditory disorders with and without ADHD. Riccio, C.A., Cohen, M.J., Hynd, G.W., Keith, R.W. Journal of learning disabilities. (1996) [Pubmed]
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