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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Task Performance and Analysis

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Disease relevance of Task Performance and Analysis


Psychiatry related information on Task Performance and Analysis


High impact information on Task Performance and Analysis

  • Transdermal nicotine replacement improved task performance in smokers and increased task-induced brain activation in the parietal cortex, thalamus, and caudate, while nicotine induced a generalized increase in occipital cortex activity [10].
  • We used a novel brain electrical imaging method to investigate rapid and continuous changes in brain activity during the continuous performance task (CPT) in normal boys and in boys with ADHD [11].
  • The brain metabolic patterns of clozapine- and fluphenazine-treated patients with schizophrenia during a continuous performance task [12].
  • Task-related neural activity in bilateral PFC showed a predicted pattern: an Emotion x Stimulus crossover interaction, with no main effects, with activity predicting task performance [13].
  • These findings suggest that cognitive activity can deplete extracellular glucose in the hippocampus and that exogenous glucose administration reverses the depletion while enhancing task performance [14].

Chemical compound and disease context of Task Performance and Analysis

  • During treatment with Lupron alone (i.e., with virtual absence of gonadal steroid hormones), there was marked attenuation of the typical Wisconsin Card Sorting Test activation pattern even though task performance did not change [15].
  • Interestingly, the increase in cortical activation during the working memory task in the hypodopaminergic state positively correlated with errors in task performance, and the increased activation in the cortical motor regions during the dopamine-replete state was positively correlated with improvement in motor function [16].
  • However, the combination of SIB-1508Y and levodopa/benserazide caused significant improvements in both cognition and motor aspects of task performance, and did so at one third to one sixth of the levodopa dose necessary to improve only motor function [17].
  • After stabilization on donepezil (5.7 +/- 1.7 weeks at 10 mg) patients showed increased frontal activity relative to unmedicated controls, which was positively correlated with improvement in task performance (r = 0.49, P = 0.05) as well as baseline hippocampal volume (r = 0.62, P < 0.05) [18].
  • Task performance accuracy diminished in the placebo group (P = 0.02), but remained constant in the raloxifene group (P = 0.60) [19].

Biological context of Task Performance and Analysis


Anatomical context of Task Performance and Analysis

  • They apply their model to neuroleptically treated schizophrenia patients who show improved task performance which they link to increased dopamine function and increased gain in the prefrontal cortex [25].
  • ERP correlates of computer-based Stroop task performance suggested a greater allocation of attention resources in the incongruent condition in both groups in the form of relatively greater negativity in the latency range 350 to 450 ms with a distribution consistent with the activation of the anterior cingulate gyrus [26].
  • We hypothesized that initial SEP amplitudes from cutaneous (sural nerve, SN) and muscle afferent (tibial nerve, TN) sources are dependent on the relevance of the specific afferent information to task performance [27].
  • Three of the four groups (treated and control adults and control old mice) did not differ from one another in task performance or neuron density in frontal cortex, cerebellum, dentate gyrus or CA1-2, CA3, CA4 hippocampal areas [28].

Gene context of Task Performance and Analysis


Analytical, diagnostic and therapeutic context of Task Performance and Analysis


  1. Cognitive and neural hippocampal effects of long-term moderate recurrent hypoglycemia. McNay, E.C., Williamson, A., McCrimmon, R.J., Sherwin, R.S. Diabetes (2006) [Pubmed]
  2. Impaired simultaneous cognitive task performance in Parkinson's disease: a dopamine-related dysfunction. Malapani, C., Pillon, B., Dubois, B., Agid, Y. Neurology (1994) [Pubmed]
  3. Kraepelinian and non-Kraepelinian schizophrenia subgroup differences in cerebral metabolic rate. Buchsbaum, M.S., Shihabuddin, L., Hazlett, E.A., Schröder, J., Haznedar, M.M., Powchik, P., Spiegel-Cohen, J., Wei, T., Singer, M.B., Davis, K.L. Schizophr. Res. (2002) [Pubmed]
  4. Residual neurobehavioral impairment in a water technician exposed to hydrazine-containing mixtures. Richter, E.D., Gal, A., Bitchatchi, E., Reches, A. Isr. J. Med. Sci. (1992) [Pubmed]
  5. Methylphenidate effects in attention deficit/hyperactivity disorder: electrodermal and ERP measures during a continuous performance task. Lawrence, C.A., Barry, R.J., Clarke, A.R., Johnstone, S.J., McCarthy, R., Selikowitz, M., Broyd, S.J. Psychopharmacology (Berl.) (2005) [Pubmed]
  6. The effects of food deprivation and incentive motivation on blood glucose levels and cognitive function. Green, M.W., Elliman, N.A., Rogers, P.J. Psychopharmacology (Berl.) (1997) [Pubmed]
  7. The rat nucleus accumbens is involved in guiding of instrumental responses by stimuli predicting reward magnitude. Giertler, C., Bohn, I., Hauber, W. Eur. J. Neurosci. (2003) [Pubmed]
  8. Single doses of Panax ginseng (G115) reduce blood glucose levels and improve cognitive performance during sustained mental activity. Reay, J.L., Kennedy, D.O., Scholey, A.B. J. Psychopharmacol. (Oxford) (2005) [Pubmed]
  9. Speed, speed variability, and accuracy of information processing in 5 to 6-year-old children at risk of ADHD. Kalff, A.C., De Sonneville, L.M., Hurks, P.P., Hendriksen, J.G., Kroes, M., Feron, F.J., Steyaert, J., van Zeben, T.M., Vles, J.S., Jolles, J. Journal of the International Neuropsychological Society : JINS. (2005) [Pubmed]
  10. Cognitive mechanisms of nicotine on visual attention. Lawrence, N.S., Ross, T.J., Stein, E.A. Neuron (2002) [Pubmed]
  11. Functional brain electrical activity mapping in boys with attention-deficit/hyperactivity disorder. Silberstein, R.B., Farrow, M., Levy, F., Pipingas, A., Hay, D.A., Jarman, F.C. Arch. Gen. Psychiatry (1998) [Pubmed]
  12. The brain metabolic patterns of clozapine- and fluphenazine-treated patients with schizophrenia during a continuous performance task. Cohen, R.M., Nordahl, T.E., Semple, W.E., Andreason, P., Litman, R.E., Pickar, D. Arch. Gen. Psychiatry (1997) [Pubmed]
  13. Integration of emotion and cognition in the lateral prefrontal cortex. Gray, J.R., Braver, T.S., Raichle, M.E. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  14. Decreases in rat extracellular hippocampal glucose concentration associated with cognitive demand during a spatial task. McNay, E.C., Fries, T.M., Gold, P.E. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  15. Modulation of cognition-specific cortical activity by gonadal steroids: a positron-emission tomography study in women. Berman, K.F., Schmidt, P.J., Rubinow, D.R., Danaceau, M.A., Van Horn, J.D., Esposito, G., Ostrem, J.L., Weinberger, D.R. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  16. Dopaminergic modulation of cortical function in patients with Parkinson's disease. Mattay, V.S., Tessitore, A., Callicott, J.H., Bertolino, A., Goldberg, T.E., Chase, T.N., Hyde, T.M., Weinberger, D.R. Ann. Neurol. (2002) [Pubmed]
  17. Effects of the nicotinic acetylcholine receptor agonist SIB-1508Y on object retrieval performance in MPTP-treated monkeys: comparison with levodopa treatment. Schneider, J.S., Van Velson, M., Menzaghi, F., Lloyd, G.K. Ann. Neurol. (1998) [Pubmed]
  18. Cholinergic enhancement of frontal lobe activity in mild cognitive impairment. Saykin, A.J., Wishart, H.A., Rabin, L.A., Flashman, L.A., McHugh, T.L., Mamourian, A.C., Santulli, R.B. Brain (2004) [Pubmed]
  19. Raloxifene exposure enhances brain activation during memory performance in healthy elderly males; its possible relevance to behavior. Goekoop, R., Duschek, E.J., Knol, D.L., Barkhof, F., Netelenbos, C., Scheltens, P., Rombouts, S.A. Neuroimage (2005) [Pubmed]
  20. Continuous-processing--related event-related potentials in children with attention deficit hyperactivity disorder. Strandburg, R.J., Marsh, J.T., Brown, W.S., Asarnow, R.F., Higa, J., Harper, R., Guthrie, D. Biol. Psychiatry (1996) [Pubmed]
  21. Cognitive performance is associated with glucose regulation in healthy elderly persons and can be enhanced with glucose and dietary carbohydrates. Kaplan, R.J., Greenwood, C.E., Winocur, G., Wolever, T.M. Am. J. Clin. Nutr. (2000) [Pubmed]
  22. Nicotine and behavioral markers of risk for schizophrenia: a double-blind, placebo-controlled, cross-over study. Dépatie, L., O'Driscoll, G.A., Holahan, A.L., Atkinson, V., Thavundayil, J.X., Kin, N.N., Lal, S. Neuropsychopharmacology (2002) [Pubmed]
  23. Modafinil improves cognition and attentional set shifting in patients with chronic schizophrenia. Turner, D.C., Clark, L., Pomarol-Clotet, E., McKenna, P., Robbins, T.W., Sahakian, B.J. Neuropsychopharmacology (2004) [Pubmed]
  24. Methamphetamine attenuates disruptions in performance and mood during simulated night-shift work. Hart, C.L., Ward, A.S., Haney, M., Nasser, J., Foltin, R.W. Psychopharmacology (Berl.) (2003) [Pubmed]
  25. Schizophrenic deficits: neuroleptics and the prefrontal cortex. Jobe, T.H., Harrow, M., Martin, E.M., Whitfield, H.J., Sands, J.R. Schizophrenia bulletin. (1994) [Pubmed]
  26. Effect of mild head injury on event-related potential correlates of Stroop task performance. Potter, D.D., Jory, S.H., Bassett, M.R., Barrett, K., Mychalkiw, W. Journal of the International Neuropsychological Society : JINS. (2002) [Pubmed]
  27. Task-relevant selective modulation of somatosensory afferent paths from the lower limb. Staines, W.R., Brooke, J.D., McIlroy, W.E. Neuroreport (2000) [Pubmed]
  28. Effect of chronic treatment with recombinant interleukin-2 on the central nervous system of adult and old mice. Nemni, R., Iannaccone, S., Quattrini, A., Smirne, S., Sessa, M., Lodi, M., Erminio, C., Canal, N. Brain Res. (1992) [Pubmed]
  29. Creatine kinase B-driven energy transfer in the brain is important for habituation and spatial learning behaviour, mossy fibre field size and determination of seizure susceptibility. Jost, C.R., Van Der Zee, C.E., In 't Zandt, H.J., Oerlemans, F., Verheij, M., Streijger, F., Fransen, J., Heerschap, A., Cools, A.R., Wieringa, B. Eur. J. Neurosci. (2002) [Pubmed]
  30. Pre- and postnatally administered ACTH, Organon 2766 and CRF facilitate or inhibit active avoidance task performance in young adult mice. Honour, L.C., White, M.H. Peptides (1988) [Pubmed]
  31. Differential effects of typical and atypical antipsychotics on nerve growth factor and choline acetyltransferase expression in the cortex and nucleus basalis of rats. Parikh, V., Khan, M.M., Terry, A., Mahadik, S.P. Journal of psychiatric research. (2004) [Pubmed]
  32. The effect of NMDA-NR2B receptor subunit over-expression on olfactory memory task performance in the mouse. White, T.L., Youngentob, S.L. Brain Res. (2004) [Pubmed]
  33. Attention and regional cerebral blood flow in posttraumatic stress disorder patients with substance abuse histories. Semple, W.E., Goyer, P.F., McCormick, R., Compton-Toth, B., Morris, E., Donovan, B., Muswick, G., Nelson, D., Garnett, M.L., Sharkoff, J., Leisure, G., Miraldi, F., Schulz, S.C. Psychiatry research. (1996) [Pubmed]
  34. Selective reductions in prefrontal glucose metabolism in murderers. Raine, A., Buchsbaum, M.S., Stanley, J., Lottenberg, S., Abel, L., Stoddard, J. Biol. Psychiatry (1994) [Pubmed]
  35. Ketamine and fMRI BOLD signal: distinguishing between effects mediated by change in blood flow versus change in cognitive state. Abel, K.M., Allin, M.P., Kucharska-Pietura, K., Andrew, C., Williams, S., David, A.S., Phillips, M.L. Human brain mapping. (2003) [Pubmed]
  36. Maintenance of alertness and performance by a brief nap after lunch under prior sleep deficit. Takahashi, M., Arito, H. Sleep. (2000) [Pubmed]
  37. Deficits in reaction times and movement times as correlates of hypokinesia in monkeys with MPTP-induced striatal dopamine depletion. Schultz, W., Studer, A., Romo, R., Sundström, E., Jonsson, G., Scarnati, E. J. Neurophysiol. (1989) [Pubmed]
  38. Specific abnormalities in serotonin release in the prefrontal cortex of isolation-reared rats measured during behavioural performance of a task assessing visuospatial attention and impulsivity. Dalley, J.W., Theobald, D.E., Pereira, E.A., Li, P.M., Robbins, T.W. Psychopharmacology (Berl.) (2002) [Pubmed]
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