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Gene Review

clpP  -  proteolytic subunit of ClpA-ClpP and ClpX...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0431, JW0427, lopP, wseA
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Disease relevance of clpP


High impact information on clpP

  • The clpP gene is at 10 min on the E. coli map, close to that for the ATP-dependent Lon protease of E. coli and far from the gene for clpA [5].
  • The DNA sequence of the clpP gene predicts a protein of 207 amino acids (Mr 21,679), which is in close agreement with the size determined by sodium dodecyl sulfate-gel electrophoresis of purified Clp P [5].
  • Insertion mutations in clpP have been isolated and transferred to the chromosome; strains devoid of Clp P are viable in the presence or absence of Lon protease [5].
  • This turnover is dependent on the clpP and clpX genes [6].
  • Increased levels of MecA in the absence of ClpP are at least partly responsible for the observed pleiotropic phenotype of the delta clpP mutant [2].

Biological context of clpP

  • For example, in the clpP and clpA mutant cultures, the Dps protein, the WrbA protein, and the periplasmic lysine-arginine-ornithine binding protein ArgT did not display the induction typical for late-stationary-phase wild-type cells [7].
  • An analysis of the degradation kinetics shows that Rep is a target of two protease systems: inactivation of either the clpP or lon gene results in a stabilization of Rep. Such a reaction scheme explains the counterintuitive observation that derepression is correlated with high repressor concentration [8].
  • In this study, we further investigated the underlying mechanism of virulence attenuation by the clpP mutation [9].
  • Nucleotide sequence analysis of the Streptococcus salivarius clpP locus revealed potential binding sites for both the CtsR and HrcA repressors [10].
  • Based on the amino acid sequences of the Bacillus subtilis clpC and clpP genes, we identified one clpC gene and two clpP genes (designated clpP1 and clpP2) in Bacillus thuringiensis [3].

Anatomical context of clpP

  • In addition, the clpP mutant was defective in colonization of the nasopharynx and survival in the lungs of mice after intranasal challenge [9].

Associations of clpP with chemical compounds

  • Lethality fixation did progress when protein synthesis was restricted and the cells were incubated in the presence of puromycin or were either clpP or clpX defective [11].


  1. The ClpP component of Clp protease is the sigma 32-dependent heat shock protein F21.5. Kroh, H.E., Simon, L.D. J. Bacteriol. (1990) [Pubmed]
  2. ClpP of Bacillus subtilis is required for competence development, motility, degradative enzyme synthesis, growth at high temperature and sporulation. Msadek, T., Dartois, V., Kunst, F., Herbaud, M.L., Denizot, F., Rapoport, G. Mol. Microbiol. (1998) [Pubmed]
  3. Distinct clpP genes control specific adaptive responses in Bacillus thuringiensis. Fedhila, S., Msadek, T., Nel, P., Lereclus, D. J. Bacteriol. (2002) [Pubmed]
  4. Inactivation of the clpP1 gene for the proteolytic subunit of the ATP-dependent Clp protease in the cyanobacterium Synechococcus limits growth and light acclimation. Clarke, A.K., Schelin, J., Porankiewicz, J. Plant Mol. Biol. (1998) [Pubmed]
  5. Sequence and structure of Clp P, the proteolytic component of the ATP-dependent Clp protease of Escherichia coli. Maurizi, M.R., Clark, W.P., Katayama, Y., Rudikoff, S., Pumphrey, J., Bowers, B., Gottesman, S. J. Biol. Chem. (1990) [Pubmed]
  6. Dynamic control of Dps protein levels by ClpXP and ClpAP proteases in Escherichia coli. Stephani, K., Weichart, D., Hengge, R. Mol. Microbiol. (2003) [Pubmed]
  7. Global role for ClpP-containing proteases in stationary-phase adaptation of Escherichia coli. Weichart, D., Querfurth, N., Dreger, M., Hengge-Aronis, R. J. Bacteriol. (2003) [Pubmed]
  8. Control of bacteriophage mu lysogenic repression. Ranquet, C., Toussaint, A., de Jong, H., Maenhaut-Michel, G., Geiselmann, J. J. Mol. Biol. (2005) [Pubmed]
  9. The ClpP protease of Streptococcus pneumoniae modulates virulence gene expression and protects against fatal pneumococcal challenge. Kwon, H.Y., Ogunniyi, A.D., Choi, M.H., Pyo, S.N., Rhee, D.K., Paton, J.C. Infect. Immun. (2004) [Pubmed]
  10. ClpP of Streptococcus salivarius is a novel member of the dually regulated class of stress response genes in gram-positive bacteria. Chastanet, A., Msadek, T. J. Bacteriol. (2003) [Pubmed]
  11. DNA damage-processing in E. coli: on-going protein synthesis is required for fixation of UV-induced lethality and mutation. Burger, A., Raymer, J., Bockrath, R. DNA Repair (Amst.) (2002) [Pubmed]
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