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Gene Review

nadE  -  NAD synthetase, NH3/glutamine-dependent

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1738, JW1729, efg, ntrL
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Disease relevance of nadE


High impact information on nadE


Chemical compound and disease context of nadE

  • Glutamine-dependent NAD synthetase activity was found in crude extracts of E. coli but not in the purified enzyme, suggesting that it may be catalyzed by an additional subunit [3].

Analytical, diagnostic and therapeutic context of nadE


  1. Structural gene for NAD synthetase in Salmonella typhimurium. Hughes, K.T., Olivera, B.M., Roth, J.R. J. Bacteriol. (1988) [Pubmed]
  2. Structures of Escherichia coli NAD synthetase with substrates and products reveal mechanistic rearrangements. Jauch, R., Humm, A., Huber, R., Wahl, M.C. J. Biol. Chem. (2005) [Pubmed]
  3. The Escherichia coli efg gene and the Rhodobacter capsulatus adgA gene code for NH3-dependent NAD synthetase. Willison, J.C., Tissot, G. J. Bacteriol. (1994) [Pubmed]
  4. The outB gene of Bacillus subtilis codes for NAD synthetase. Nessi, C., Albertini, A.M., Speranza, M.L., Galizzi, A. J. Biol. Chem. (1995) [Pubmed]
  5. Stable ammonia-specific NAD synthetase from Bacillus stearothermophilus: purification, characterization, gene cloning, and applications. Yamaguchi, F., Koga, S., Yoshioka, I., Takahashi, M., Sakuraba, H., Ohshima, T. Biosci. Biotechnol. Biochem. (2002) [Pubmed]
  6. The crystal structure of GMP synthetase reveals a novel catalytic triad and is a structural paradigm for two enzyme families. Tesmer, J.J., Klem, T.J., Deras, M.L., Davisson, V.J., Smith, J.L. Nat. Struct. Biol. (1996) [Pubmed]
  7. Comparative genomics of NAD biosynthesis in cyanobacteria. Gerdes, S.Y., Kurnasov, O.V., Shatalin, K., Polanuyer, B., Sloutsky, R., Vonstein, V., Overbeek, R., Osterman, A.L. J. Bacteriol. (2006) [Pubmed]
  8. Structural study of Escherichia coli NAD synthetase: overexpression, purification, crystallization, and preliminary crystallographic analysis. Ozment, C., Barchue, J., DeLucas, L.J., Chattopadhyay, D. J. Struct. Biol. (1999) [Pubmed]
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