The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

creC  -  sensory histidine kinase in two-component...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK4391, JW4362, phoM
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of creC

  • The phoM gene is one of the positive regulatory genes for the phosphate regulon of Escherichia coli [1].
  • A phoM-lacZ protein fusion was constructed by using a plasmid carrying the phoM gene and a derivative of phage lambda, lambda plac Mu2 [2].

High impact information on creC

  • No effect of phosphate concentration on cet or phoM gene expression could be found and thus their primary function may not be connected to the phosphate regulon [3].
  • PhoM1206 could also transphosphorylate the product of phoM-orf2, which is structurally homologous to phoB and located immediately upstream of phoM [4].
  • By molecular cloning of the wild-type phoM operon onto a multicopy plasmid and recombining onto the plasmid the pho-510 mutation that abolishes variation, the phoM operon, rather than some nearby gene, was shown to control variation [5].
  • However, phoM operon expression was unaffected when tested with phoM operon lacZ transcriptional fusions [6].
  • These data are consistent with the wild-type phoM operon having a negative, as well as a positive, regulatory role in gene expression [6].

Chemical compound and disease context of creC


Biological context of creC


Associations of creC with chemical compounds

  • The switching is regulated by the phoM operon and the presence of glucose; the pho-510 mutant form of the phoM operon abolishes both BAP clonal variation and the effect of glucose (B.L. Wanner, J. Bacteriol. 169:900-903, 1987) [6].

Analytical, diagnostic and therapeutic context of creC


WikiGenes - Universities