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Gene Review

deoB  -  phosphopentomutase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK4375, JW4346, drm, thyR, tlr
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Disease relevance of deoB


High impact information on deoB

  • From a strain in which Mu-1 is inserted in drm, a mutant has been isolated that has a deletion extending into tpp [1].
  • Northern blot and enzyme analyses showed that drm and pupG form a dicistronic operon [3].
  • The characterization of two closely linked loci, drm and pupG, which encode phosphopentomutase (Drm) and guanosine (inosine) phosphorylase (PupG), respectively, is reported here [3].
  • It relies on the detection as papillae on thy colonies of second mutations either at the dra or drm locus [4].
  • E. coli transformants expressing phosphopentomutase and nucleoside phosphorylase produced 2'-deoxyribonucleosides from 2-deoxyribose 5-phosphate and a nucleobase via 2-deoxyribose 1-phosphate through the reverse reactions of 2'-deoxyribonucleoside degradation [5].

Other interactions of deoB


  1. Genetic analysis of thymidine-resistant and low-thymine-requiring mutants of Escherichia coli K-12 induced by bacteriophage Mu-1. Buxton, R.S. J. Bacteriol. (1975) [Pubmed]
  2. Discrimination between bromouracil and thymine for uptake into DNA in drm- and dra- mutants of Escherichia coli K12. Ryderg, B. Biochim. Biophys. Acta (1977) [Pubmed]
  3. Nucleosides as a carbon source in Bacillus subtilis: characterization of the drm-pupG operon. Schuch, R., Garibian, A., Saxild, H.H., Piggot, P.J., Nygaard, P. Microbiology (Reading, Engl.) (1999) [Pubmed]
  4. A general method for selecting strains of Escherichia coli having altered spontaneous or induced mutabilities. Grigg, G.W. Mutat. Res. (1993) [Pubmed]
  5. Biochemical retrosynthesis of 2'-deoxyribonucleosides from glucose, acetaldehyde, and a nucleobase. Horinouchi, N., Ogawa, J., Kawano, T., Sakai, T., Saito, K., Matsumoto, S., Sasaki, M., Mikami, Y., Shimizu, S. Appl. Microbiol. Biotechnol. (2006) [Pubmed]
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