The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

deoC  -  2-deoxyribose-5-phosphate aldolase, NAD(P)...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK4373, JW4344, dra, thyR, tlr
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of deoC


High impact information on deoC

  • The dra operon includes the draB and draC genes, whose products exhibit homology to chaperone-usher proteins involved in the biogenesis of surface-located polymeric structures [4].
  • Twenty-three (21%) of the 110 E. coli isolates (13 resistant, 10 susceptible) satisfied criteria for extraintestinal pathogenic E. coli (ExPEC), i.e., exhibited >or=2 of pap (P fimbriae), sfa/foc (S/F1C fimbriae), afa/dra (Dr binding adhesins), iutA (aerobactin receptor), and kpsMT II (group 2 capsule synthesis) [5].
  • Experiments conducted with the laboratory strain E. coli K-12 EC901 carrying the recombinant plasmid pBJN406, which expresses Dr hemagglutinin, demonstrated that the dra operon is involved in polarized entry of IH11128 bacteria [6].
  • The remaining five dra-positive strains agglutinated Dr(a-) erythrocytes [7].
  • The dra gene cluster of uropathogenic strains of Escherichia coli produces proteins involved in bacterial attachment to and invasion of the eukaryotic host tissues [8].

Chemical compound and disease context of deoC


Biological context of deoC

  • The results confirm the order of the gene in the controlling region to be deoPO-cytPO and the mutation, previously analysed as a deletion, appears to have deleted cytPO deoC region of the chromosome [10].
  • Mutants with genotype thyA- dra- discriminate against bromouracil to much greater extent than do mutants with genotype thyA- drm-. 2 [11].
  • This region (23351 bp) contains 25 complete open reading frames (ORFs; genes) including deoR, dra, nupC and pdp and two partial ones [12].
  • Using PCR and primers for the afaB gene, we detected dra-related operons in 17 isolates (27%) [7].
  • The expression of DraD and its role in the biogenesis of Dr fimbriae were determined by constructing mutants in the dra operon and by immunoblot and immunofluorescence experiments [13].

Other interactions of deoC

  • It relies on the detection as papillae on thy colonies of second mutations either at the dra or drm locus [14].

Analytical, diagnostic and therapeutic context of deoC

  • Peptide mass fingerprints from both spots showed similar MALDI spectra and 10 of 10 tryptic fragments confirmed the identity as deoC [15].


  1. Structure and function of the intercistronic regulatory deoC-deoA element of Escherichia coli K-12. Valentin-Hansen, P., Hammer-Jespersen, K., Boetius, F., Svendsen, I. EMBO J. (1984) [Pubmed]
  2. Identification, molecular cloning, and sequence analysis of a deoxyribose aldolase in Streptococcus mutans GS-5. Han, T.K., Zhu, Z., Dao, M.L. Curr. Microbiol. (2004) [Pubmed]
  3. Development of experimental model of chronic pyelonephritis with Escherichia coli O75:K5:H-bearing Dr fimbriae: mutation in the dra region prevented tubulointerstitial nephritis. Goluszko, P., Moseley, S.L., Truong, L.D., Kaul, A., Williford, J.R., Selvarangan, R., Nowicki, S., Nowicki, B. J. Clin. Invest. (1997) [Pubmed]
  4. Molecular aspects of biogenesis of Escherichia coli Dr Fimbriae: characterization of DraB-DraE complexes. Piatek, R., Zalewska, B., Kolaj, O., Ferens, M., Nowicki, B., Kur, J. Infect. Immun. (2005) [Pubmed]
  5. Isolation and molecular characterization of nalidixic acid-resistant extraintestinal pathogenic Escherichia coli from retail chicken products. Johnson, J.R., Murray, A.C., Gajewski, A., Sullivan, M., Snippes, P., Kuskowski, M.A., Smith, K.E. Antimicrob. Agents Chemother. (2003) [Pubmed]
  6. Polarized entry of uropathogenic Afa/Dr diffusely adhering Escherichia coli strain IH11128 into human epithelial cells: evidence for alpha5beta1 integrin recognition and subsequent internalization through a pathway involving caveolae and dynamic unstable microtubules. Guignot, J., Bernet-Camard, M.F., Poüs, C., Plançon, L., Le Bouguenec, C., Servin, A.L. Infect. Immun. (2001) [Pubmed]
  7. dra-related X adhesins of gestational pyelonephritis-associated Escherichia coli recognize SCR-3 and SCR-4 domains of recombinant decay-accelerating factor. Pham, T., Kaul, A., Hart, A., Goluszko, P., Moulds, J., Nowicki, S., Lublin, D.M., Nowicki, B.J. Infect. Immun. (1995) [Pubmed]
  8. Structure of DraD invasin from uropathogenic Escherichia coli: a dimer with swapped beta-tails. Jedrzejczak, R., Dauter, Z., Dauter, M., Piatek, R., Zalewska, B., Mróz, M., Bury, K., Nowicki, B., Kur, J. Acta Crystallogr. D Biol. Crystallogr. (2006) [Pubmed]
  9. The primary structure of Escherichia coli K12 2-deoxyribose 5-phosphate aldolase. Nucleotide sequence of the deoC gene and the amino acid sequence of the enzyme. Valentin-Hansen, P., Boëtius, F., Hammer-Jespersen, K., Svendsen, I. Eur. J. Biochem. (1982) [Pubmed]
  10. Regulation of the synthesis of nucleoside catabolic enzymes in Escherichia coli: further analysis of a deo Oc mutant strain. Albrechtsen, H., Ahmad, S.I. Mol. Gen. Genet. (1980) [Pubmed]
  11. Discrimination between bromouracil and thymine for uptake into DNA in drm- and dra- mutants of Escherichia coli K12. Ryderg, B. Biochim. Biophys. Acta (1977) [Pubmed]
  12. Cloning and sequencing of a 23-kb region of the Bacillus subtilis genome between the iol and hut operons. Yoshida, K., Fujimura, M., Yanai, N., Fujita, Y. DNA Res. (1995) [Pubmed]
  13. A surface-exposed DraD protein of uropathogenic Escherichia coli bearing Dr fimbriae may be expressed and secreted independently from DraC usher and DraE adhesin. Zalewska, B., Piatek, R., Bury, K., Samet, A., Nowicki, B., Nowicki, S., Kur, J. Microbiology (Reading, Engl.) (2005) [Pubmed]
  14. A general method for selecting strains of Escherichia coli having altered spontaneous or induced mutabilities. Grigg, G.W. Mutat. Res. (1993) [Pubmed]
  15. Characterization of periplasmic Escherichia coli protein expression at high cell densities. Franzén, B., Becker, S., Mikkola, R., Tidblad, K., Tjernberg, A., Birnbaum, S. Electrophoresis (1999) [Pubmed]
WikiGenes - Universities