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Gene Review

deoA  -  thymidine phosphorylase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK4374, JW4345, TP, tpp, ttg
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Disease relevance of deoA


High impact information on deoA


Biological context of deoA


Associations of deoA with chemical compounds


Other interactions of deoA


  1. Structure and function of the intercistronic regulatory deoC-deoA element of Escherichia coli K-12. Valentin-Hansen, P., Hammer-Jespersen, K., Boetius, F., Svendsen, I. EMBO J. (1984) [Pubmed]
  2. Three-dimensional structure of thymidine phosphorylase from Escherichia coli at 2.8 A resolution. Walter, M.R., Cook, W.J., Cole, L.B., Short, S.A., Koszalka, G.W., Krenitsky, T.A., Ealick, S.E. J. Biol. Chem. (1990) [Pubmed]
  3. Expression of platelet-derived endothelial cell growth factor in Escherichia coli and confirmation of its thymidine phosphorylase activity. Moghaddam, A., Bicknell, R. Biochemistry (1992) [Pubmed]
  4. De novo synthesis of thymidylate via deoxycytidine in dcd (dCTP deaminase) mutants of Escherichia coli. Weiss, B., Wang, L. J. Bacteriol. (1994) [Pubmed]
  5. Cloning and characterization of upp, a gene encoding uracil phosphoribosyltransferase from Lactococcus lactis. Martinussen, J., Hammer, K. J. Bacteriol. (1994) [Pubmed]
  6. Genetic analysis of thymidine-resistant and low-thymine-requiring mutants of Escherichia coli K-12 induced by bacteriophage Mu-1. Buxton, R.S. J. Bacteriol. (1975) [Pubmed]
  7. Multiple regulation of nucleoside catabolizing enzymes: effects of a polar dra mutation on the deo enzymes. Albrechtsen, H., Hammer-Jespersen, K., Munch-Petersen, A., Fiil, N. Mol. Gen. Genet. (1976) [Pubmed]
  8. Overexpression of Escherichia coli genes encoding nucleoside phosphorylases in the pET/Bl21(DE3) system yields active recombinant enzymes. Esipov, R.S., Gurevich, A.I., Chuvikovsky, D.V., Chupova, L.A., Muravyova, T.I., Miroshnikov, A.I. Protein Expr. Purif. (2002) [Pubmed]
  9. Thymidine phosphorylase from Escherichia coli: tight-binding inhibitors as enzyme active-site titrants. Gbaj, A., Edwards, P.N., Reigan, P., Freeman, S., Jaffar, M., Douglas, K.T. Journal of enzyme inhibition and medicinal chemistry. (2006) [Pubmed]
  10. Identification of a novel class of inhibitor of human and Escherichia coli thymidine phosphorylase by in silico screening. McNally, V.A., Gbaj, A., Douglas, K.T., Stratford, I.J., Jaffar, M., Freeman, S., Bryce, R.A. Bioorg. Med. Chem. Lett. (2003) [Pubmed]
  11. Cloning and characterization of a gene encoding trehalose phosphorylase (TP) from Pleurotus sajor-caju. Han, S.E., Kwon, H.B., Lee, S.B., Yi, B.Y., Murayama, I., Kitamoto, Y., Byun, M.O. Protein Expr. Purif. (2003) [Pubmed]
  12. Influence of the rho-15 temperature-sensitive (ts) mutation on the expression of the deo-operon in Escherichia coli. Sukhodolets, V.V., Mironov, A.S., Linkova, E.V. Mol. Gen. Genet. (1982) [Pubmed]
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