The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

GOSR2  -  golgi SNAP receptor complex member 2

Homo sapiens

Synonyms: 27 kDa Golgi SNARE protein, Bos1, EPM6, GS27, Golgi SNAP receptor complex member 2, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of GOSR2

  • The chromosomal location of GS27 near a locus implicated in familial essential hypertension and its known function in trafficking indicate that it is a potential candidate gene for this disease [1].
  • In vitro studies indicate that Bos 6-specific IgG and, to a lesser extent, Bos 1-specific IgG can cause acantholysis [2].

High impact information on GOSR2

  • Temperature shifts reveal that membrin, rsec22b, rbet1, and syntaxin 5 are present together on membranes that rapidly recycle between peripheral and Golgi-centric locations [3].
  • The 34-kD syntaxin 5 isoform, membrin, and GOS-28 may function in intraGolgi transport [3].
  • Our results indicate a central role for complexes among rbet1, rsec22b, membrin, and syntaxin 5 (34 and 41 kD) at two membrane fusion interfaces: the fusion of ER-derived vesicles with VTCs, and the assembly of VTCs to form cis-Golgi elements [3].
  • Our data suggest that Bos 6-specific IgG4 is probably the main acantholytic autoantibody, while Bos 1-specific IgG4 may act as a facilitator or enhancer of the process [2].
  • The co-localization with membrin was maintained at 15 degrees C and after microtubule depolymerization with nocodazole [4].

Biological context of GOSR2

  • cDNA characterization and chromosomal mapping of human golgi SNARE GS27 and GS28 to chromosome 17 [1].
  • Purified recombinant syntaxin 5, membrin, and rbet1, three Q-SNAREs, assemble cooperatively to create a high affinity binding site for sec22b, an R-SNARE [5].
  • Both H427 and H373 augmented the levels of intracellular reactive oxygen species (ROS) and induced apoptosis as demonstrated by terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling analysis [6].
  • Two pigmented compounds from Uroleucon nigrotuberculatum, rhododactynaphin-jc-1 (H427) and rhododactynaphin-jc-2 (H373), significantly diminished the cell viability of HL60 cells with IC(50) of 10 muM and 30 muM, respectively, in an 18 h-dye uptake assay [6].

Associations of GOSR2 with chemical compounds


Other interactions of GOSR2

  • Chromosomal mapping analyses reveal that human GS27 is located on chromosome 17q21 and GS28 on approximately 17q11 [1].

Analytical, diagnostic and therapeutic context of GOSR2


  1. cDNA characterization and chromosomal mapping of human golgi SNARE GS27 and GS28 to chromosome 17. Bui, T.D., Levy, E.R., Subramaniam, V.N., Lowe, S.L., Hong, W. Genomics (1999) [Pubmed]
  2. Correlation of peptide specificity and IgG subclass with pathogenic and nonpathogenic autoantibodies in pemphigus vulgaris: a model for autoimmunity. Bhol, K., Natarajan, K., Nagarwalla, N., Mohimen, A., Aoki, V., Ahmed, A.R. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  3. Localization, dynamics, and protein interactions reveal distinct roles for ER and Golgi SNAREs. Hay, J.C., Klumperman, J., Oorschot, V., Steegmaier, M., Kuo, C.S., Scheller, R.H. J. Cell Biol. (1998) [Pubmed]
  4. Identification of a human orthologue of Sec34p as a component of the cis-Golgi vesicle tethering machinery. Suvorova, E.S., Kurten, R.C., Lupashin, V.V. J. Biol. Chem. (2001) [Pubmed]
  5. Subunit structure of a mammalian ER/Golgi SNARE complex. Xu, D., Joglekar, A.P., Williams, A.L., Hay, J.C. J. Biol. Chem. (2000) [Pubmed]
  6. Pigments from Uroleucon nigrotuberculatum Induce Apoptosis in HL60 Human Leukemia Cells, Implicating Intracellular Oxidative Stress and Activation of Caspases. Suzuki, S., Tomita, M., Hyodo, M., Horikawa, M., Tsunoda, T., Sato, M. Biol. Pharm. Bull. (2006) [Pubmed]
  7. Human Yip1A specifies the localization of Yif1 to the Golgi apparatus. Jin, C., Zhang, Y., Zhu, H., Ahmed, K., Fu, C., Yao, X. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
WikiGenes - Universities