Disease relevance of IER2

• These included transcripts encoding acute phase response proteins, IER2 and JUNB, and regulators of cell proliferation, p21Cip1 and KLF6 [1].
• ETR101 was persistently expressed in HTLV-I-infected cells but not in HTLV-I uninfected cells [2].

High impact information on IER2

• Therefore, ETR101 mRNA level is controlled, either directly or indirectly, by protein phosphorylation [3].
• The majority of genes were transcription factors such as c-jun, BTEB2, and ETR101 [4].
• These represented 10 distinct immediate-early genes that were up-regulated by m1AChR activation: Egr-1, Egr-2, Egr-3, NGFi-B, ETR101, c- jun, jun -D, Gos-3 and hcyr61, as well as the unknown gene Gig-2 [5].
• These included the transcription factors Egr-1, Egr-2, Egr-3, c-Jun, Jun-D and Gos-3; the growth regulator hCyr61; the signalling factors NGFi-B (nerve growth factor induced gene-B) and Etr101; the unknown gene Gig-2 (for G-protein-coupled receptor induced gene 2); and the acetylcholinesterase gene (ACHE) [6].
• Tax transactivated the ETR101 gene promoter in a transient transfection assay [2].

Biological context of IER2

• A series of deletion and mutation analyses of the ETR101 gene promoter indicated that a 35 bp region immediately upstream of the TATA-box sequence, which contains a consensus cAMP response element (CRE) and a G+C-rich sequence, is the critical responsive element for Tax activation [2].
• Transcriptional activation of immediate-early gene ETR101 by human T-cell leukaemia virus type I Tax [2].
• These results suggested that Tax directly transactivated ETR101 gene expression, mainly through a CRE sequence via the CREB transcription pathway [2].
• The predicted amino acid sequence encoded by ETR101 has weak homology to JunB and JunD, therefore it is of some interest that these three genes share the chromosomal localization, 19p13 [7].

Anatomical context of IER2

• Expression of ETR101 was dependent upon Tax expression in the inducible Tax-expressing cell line JPX-9 and also in Jurkat cells transiently transfected with Tax-expressing vectors [2].

References