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Gene Review

JUNB  -  jun B proto-oncogene

Homo sapiens

Synonyms: Transcription factor jun-B
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Disease relevance of JUNB


High impact information on JUNB


Biological context of JUNB


Anatomical context of JUNB


Regulatory relationships of JUNB


Other interactions of JUNB

  • Immunohistochemical staining of paraffin sections from six cases demonstrated expression of JUNB protein in five cases and BCL2 in three cases [13].
  • This region was found to be sufficient for the phorbol ester-inducible transcriptional activity of JUN, but not JUNB [5].
  • Tissue factor pathway inhibitor induces expression of JUNB and GADD45B mRNAs [12].
  • TPA but not AII increased the level of the transcription factor JunB in nuclear extracts and the increase was partially abolished by the MEK1 inhibitor PD98059 [14].


  1. Amplification and overexpression of JUNB is associated with primary cutaneous T-cell lymphomas. Mao, X., Orchard, G., Lillington, D.M., Russell-Jones, R., Young, B.D., Whittaker, S.J. Blood (2003) [Pubmed]
  2. Influence of surgical manipulation on prostate gene expression: implications for molecular correlates of treatment effects and disease prognosis. Lin, D.W., Coleman, I.M., Hawley, S., Dumpit, R., Gifford, D., Kezele, P., Hung, H., Knudsen, B.S., Kristal, A.R., Nelson, P.S. J. Clin. Oncol. (2006) [Pubmed]
  3. PU.1 and Junb: Suppressing the formation of acute myeloid leukemia stem cells. Somervaille, T.C., Cleary, M.L. Cancer Cell (2006) [Pubmed]
  4. Gene expression profiling of Japanese psoriatic skin reveals an increased activity in molecular stress and immune response signals. Kulski, J.K., Kenworthy, W., Bellgard, M., Taplin, R., Okamoto, K., Oka, A., Mabuchi, T., Ozawa, A., Tamiya, G., Inoko, H. J. Mol. Med. (2005) [Pubmed]
  5. Phorbol ester-induced amino-terminal phosphorylation of human JUN but not JUNB regulates transcriptional activation. Franklin, C.C., Sanchez, V., Wagner, F., Woodgett, J.R., Kraft, A.S. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  6. The Synovial Sarcoma-Associated SS18-SSX2 Fusion Protein Induces Epigenetic Gene (De)Regulation. de Bruijn, D.R., Allander, S.V., van Dijk, A.H., Willemse, M.P., Thijssen, J., van Groningen, J.J., Meltzer, P.S., Geurts van Kessel, A. Cancer Res. (2006) [Pubmed]
  7. Distinct oligomeric states of SMAD proteins in the transforming growth factor-beta pathway. Jayaraman, L., Massague, J. J. Biol. Chem. (2000) [Pubmed]
  8. Transcription factor jun-B is target of autoreactive T-cells in IDDM. Honeyman, M.C., Cram, D.S., Harrison, L.C. Diabetes (1993) [Pubmed]
  9. Transcriptional interactions of transforming growth-factor-beta with pro-inflammatory cytokines. Mauviel, A., Qiu Chen, Y., Dong, W., Evans, C.H., Uitto, J. Curr. Biol. (1993) [Pubmed]
  10. The protein kinase N (PKN) gene PRKCL1/Prkcl1 maps to human chromosome 19p12-p13.1 and mouse chromosome 8 with close linkage to the myodystrophy (myd) mutation. Bartsch, J.W., Mukai, H., Takahashi, N., Ronsiek, M., Fuchs, S., Jockusch, H., Ono, Y. Genomics (1998) [Pubmed]
  11. BCL2 and JUNB abnormalities in primary cutaneous lymphomas. Mao, X., Orchard, G., Lillington, D.M., Child, F.J., Vonderheid, E.C., Nowell, P.C., Bagot, M., Bensussan, A., Russell-Jones, R., Young, B.D., Whittaker, S.J. Br. J. Dermatol. (2004) [Pubmed]
  12. Tissue factor pathway inhibitor induces expression of JUNB and GADD45B mRNAs. Shirotani-Ikejima, H., Kokame, K., Hamuro, T., Bu, G., Kato, H., Miyata, T. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  13. Genetic alterations in primary cutaneous CD30+ anaplastic large cell lymphoma. Mao, X., Orchard, G., Lillington, D.M., Russell-Jones, R., Young, B.D., Whittaker, S. Genes Chromosomes Cancer (2003) [Pubmed]
  14. On the control of the hCYP11B2 gene expressing cytochrome P450 aldosterone synthase. LeHoux, J.G., Lefebvre, A. Endocr. Res. (2004) [Pubmed]
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