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Gene Review

KLF5  -  Kruppel-like factor 5 (intestinal)

Homo sapiens

Synonyms: BTE-binding protein 2, BTEB2, Basic transcription element-binding protein 2, CKLF, Colon krueppel-like factor, ...
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Disease relevance of KLF5


High impact information on KLF5


Chemical compound and disease context of KLF5


Biological context of KLF5


Anatomical context of KLF5

  • Finally, WWP1 was amplified and overexpressed in some cancer cell lines from the prostate and breast, which negatively regulated the function of KLF5 in gene regulation [8].
  • In epithelial cells, the KLF5 protein is tightly regulated by the ubiquitin-proteasome pathway [8].
  • Both genes were highly expressed in the normal bladder epithelium, whereas KLF4, but not KLF5, was frequently downregulated in bladder cancer cell lines and cancer tissues [10].
  • The KLF5 mRNA and the protein is expressed in keratinocytes and throughout the adult human epidermis [12].
  • Although both genes are expressed in the intestinal epithelium, their distributions are different: Klf4 is primarily expressed in the terminally differentiated villus cells while Klf5 is primarily in the proliferating crypt cells [13].

Associations of KLF5 with chemical compounds


Physical interactions of KLF5


Regulatory relationships of KLF5


Other interactions of KLF5

  • Gel shift DNA binding assay showed that their interaction inhibits the DNA binding activity of KLF5, suggesting a property of HDAC1 to directly affect the DNA binding affinity of a transcription factor [17].
  • Therefore, in this report we studied the involvement of the KLF4 and KLF5 genes in bladder carcinogenesis [10].
  • Mutation at a potential protein kinase C phosphorylation site within the CBP interaction domain of KLF5 reduces its transactivation function [11].
  • Regulation of platelet-derived growth factor-A chain by Krüppel-like factor 5: new pathway of cooperative activation with nuclear factor-kappaB [9].
  • Thus far PTEN is the most frequently mutated gene in prostate cancer, and KLF5 showed the most frequent hemizygous deletion and loss of expression [21].

Analytical, diagnostic and therapeutic context of KLF5


  1. Intestinal tumor progression is associated with altered function of KLF5. Bateman, N.W., Tan, D., Pestell, R.G., Black, J.D., Black, A.R. J. Biol. Chem. (2004) [Pubmed]
  2. A possible tumor suppressor role of the KLF5 transcription factor in human breast cancer. Chen, C., Bhalala, H.V., Qiao, H., Dong, J.T. Oncogene (2002) [Pubmed]
  3. KLF5 is frequently deleted and down-regulated but rarely mutated in prostate cancer. Chen, C., Bhalala, H.V., Vessella, R.L., Dong, J.T. Prostate (2003) [Pubmed]
  4. KLF5/BTEB2, a Krüppel-like zinc-finger type transcription factor, mediates both smooth muscle cell activation and cardiac hypertrophy. Nagai, R., Shindo, T., Manabe, I., Suzuki, T., Kurabayashi, M. Adv. Exp. Med. Biol. (2003) [Pubmed]
  5. Lysophosphatidic acid facilitates proliferation of colon cancer cells via induction of Krüppel-like factor 5. Zhang, H., Bialkowska, A., Rusovici, R., Chanchevalap, S., Shim, H., Katz, J.P., Yang, V.W., Yun, C.C. J. Biol. Chem. (2007) [Pubmed]
  6. Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling. Shindo, T., Manabe, I., Fukushima, Y., Tobe, K., Aizawa, K., Miyamoto, S., Kawai-Kowase, K., Moriyama, N., Imai, Y., Kawakami, H., Nishimatsu, H., Ishikawa, T., Suzuki, T., Morita, H., Maemura, K., Sata, M., Hirata, Y., Komukai, M., Kagechika, H., Kadowaki, T., Kurabayashi, M., Nagai, R. Nat. Med. (2002) [Pubmed]
  7. Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation on the DNA-binding domain. Miyamoto, S., Suzuki, T., Muto, S., Aizawa, K., Kimura, A., Mizuno, Y., Nagino, T., Imai, Y., Adachi, N., Horikoshi, M., Nagai, R. Mol. Cell. Biol. (2003) [Pubmed]
  8. Human Kruppel-like factor 5 is a target of the E3 ubiquitin ligase WWP1 for proteolysis in epithelial cells. Chen, C., Sun, X., Guo, P., Dong, X.Y., Sethi, P., Cheng, X., Zhou, J., Ling, J., Simons, J.W., Lingrel, J.B., Dong, J.T. J. Biol. Chem. (2005) [Pubmed]
  9. Regulation of platelet-derived growth factor-A chain by Krüppel-like factor 5: new pathway of cooperative activation with nuclear factor-kappaB. Aizawa, K., Suzuki, T., Kada, N., Ishihara, A., Kawai-Kowase, K., Matsumura, T., Sasaki, K., Munemasa, Y., Manabe, I., Kurabayashi, M., Collins, T., Nagai, R. J. Biol. Chem. (2004) [Pubmed]
  10. Downregulation and growth inhibitory effect of epithelial-type Krüppel-like transcription factor KLF4, but not KLF5, in bladder cancer. Ohnishi, S., Ohnami, S., Laub, F., Aoki, K., Suzuki, K., Kanai, Y., Haga, K., Asaka, M., Ramirez, F., Yoshida, T. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  11. Phosphorylation of Kruppel-like factor 5 (KLF5/IKLF) at the CBP interaction region enhances its transactivation function. Zhang, Z., Teng, C.T. Nucleic Acids Res. (2003) [Pubmed]
  12. Human Krüppel-like factor5/KLF5: synergy with NF-kappaB/Rel factors and expression in human skin and hair follicles. Sur, I., Undén, A.B., Toftgård, R. Eur. J. Cell Biol. (2002) [Pubmed]
  13. Opposing effects of Krüppel-like factor 4 (gut-enriched Krüppel-like factor) and Krüppel-like factor 5 (intestinal-enriched Krüppel-like factor) on the promoter of the Krüppel-like factor 4 gene. Dang, D.T., Zhao, W., Mahatan, C.S., Geiman, D.E., Yang, V.W. Nucleic Acids Res. (2002) [Pubmed]
  14. KLF5 Interacts with p53 in regulating survivin expression in acute lymphoblastic leukemia. Zhu, N., Gu, L., Findley, H.W., Chen, C., Dong, J.T., Yang, L., Zhou, M. J. Biol. Chem. (2006) [Pubmed]
  15. Angiotensin II and tumor necrosis factor-alpha upregulate survivin and Kruppel-like factor 5 in smooth muscle cells: Potential relevance to vein graft hyperplasia. Bafford, R., Sui, X.X., Wang, G., Conte, M. Surgery (2006) [Pubmed]
  16. Regulation of Angiotensin II-Induced Kr??ppel-Like Factor 5 Expression in Vascular Smooth Muscle Cells. Gao, D., Niu, X., Ning, N., Hao, G. Biol. Pharm. Bull. (2006) [Pubmed]
  17. The deacetylase HDAC1 negatively regulates the cardiovascular transcription factor Krüppel-like factor 5 through direct interaction. Matsumura, T., Suzuki, T., Aizawa, K., Munemasa, Y., Muto, S., Horikoshi, M., Nagai, R. J. Biol. Chem. (2005) [Pubmed]
  18. Transcriptional activation domain of human BTEB2, a GC box-binding factor. Kojima, S., Kobayashi, A., Gotoh, O., Ohkuma, Y., Fujii-Kuriyama, Y., Sogawa, K. J. Biochem. (1997) [Pubmed]
  19. KLF4 and KLF5 regulate proliferation, apoptosis and invasion in esophageal cancer cells. Yang, Y., Goldstein, B.G., Chao, H.H., Katz, J.P. Cancer Biol. Ther. (2005) [Pubmed]
  20. Transcriptional activation of the zinc finger transcription factor BTEB2 gene by Egr-1 through mitogen-activated protein kinase pathways in vascular smooth muscle cells. Kawai-Kowase, K., Kurabayashi, M., Hoshino, Y., Ohyama, Y., Nagai, R. Circ. Res. (1999) [Pubmed]
  21. Chromosomal deletions and tumor suppressor genes in prostate cancer. Dong, J.T. Cancer Metastasis Rev. (2001) [Pubmed]
  22. Expression of KLF5 is a prognostic factor for disease-free survival and overall survival in patients with breast cancer. Tong, D., Czerwenka, K., Heinze, G., Ryffel, M., Schuster, E., Witt, A., Leodolter, S., Zeillinger, R. Clin. Cancer Res. (2006) [Pubmed]
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