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Gene Review

frdB  -  fumarate reductase iron-sulfur subunit

Escherichia coli O157:H7 str. EDL933

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Disease relevance of frdB


High impact information on frdB

  • The Iron-Sulfur Clusters in Escherichia coli Succinate Dehydrogenase Direct Electron Flow [3].
  • Succinate dehydrogenase is an indispensable enzyme involved in the Krebs cycle as well as energy coupling in the mitochondria and certain prokaryotes [3].
  • These observations were made both with wild-type envelopes and with envelopes of a mutant which lacks the enzymes succinate dehydrogenase and fumarase, indicating that the switching-promoting activity of the analogues was not caused by their conversion to fumarate [4].
  • Similar to succinate dehydrogenase, it is part of both the electron transfer chain and the citric acid cycle [5].
  • During growth on glucose, but not on glycerol, activities of succinate dehydrogenase and of 2-oxoglutarate dehydrogenase were missing nearly completely [6].

Biological context of frdB


  1. The Quinone Binding Site in Escherichia coli Succinate Dehydrogenase Is Required for Electron Transfer to the Heme b. Tran, Q.M., Rothery, R.A., Maklashina, E., Cecchini, G., Weiner, J.H. J. Biol. Chem. (2006) [Pubmed]
  2. Analysis of mitochondrial antigens reveals inner membrane succinate dehydrogenase flavoprotein subunit as autoantigen to antibodies in anti-M7 sera. Cicek, G., Schiltz, E., Hess, D., Staiger, J., Brandsch, R. Clin. Exp. Immunol. (2002) [Pubmed]
  3. The Iron-Sulfur Clusters in Escherichia coli Succinate Dehydrogenase Direct Electron Flow. Cheng, V.W., Ma, E., Zhao, Z., Rothery, R.A., Weiner, J.H. J. Biol. Chem. (2006) [Pubmed]
  4. The specificity of fumarate as a switching factor of the bacterial flagellar motor. Barak, R., Giebel, I., Eisenbach, M. Mol. Microbiol. (1996) [Pubmed]
  5. Another unusual type of citric acid cycle enzyme in Helicobacter pylori: the malate:quinone oxidoreductase. Kather, B., Stingl, K., van der Rest, M.E., Altendorf, K., Molenaar, D. J. Bacteriol. (2000) [Pubmed]
  6. Functional citric acid cycle in an arcA mutant of Escherichia coli during growth with nitrate under anoxic conditions. Prohl, C., Wackwitz, B., Vlad, D., Unden, G. Arch. Microbiol. (1998) [Pubmed]
  7. Global gene expression analysis of glucose overflow metabolism in Escherichia coli and reduction of aerobic acetate formation. Veit, A., Polen, T., Wendisch, V.F. Appl. Microbiol. Biotechnol. (2007) [Pubmed]
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