Gene Review:
PAK1 - p21 protein (Cdc42/Rac)-activated kinase 1
Homo sapiens
Synonyms:
Alpha-PAK, PAK-1, Serine/threonine-protein kinase PAK 1, p21-activated kinase 1, p65-PAK
Carter,
McDonald,
Thomas,
Wary,
Kovalenko,
Turner,
Colligan,
Riedy,
Leventhal,
Pemberton,
Lim,
Madden,
Bokoch,
Deddens,
Bhatt,
Koh,
Somlyo,
Hom,
Webb,
Whitmore,
Tan,
Manser,
Graff,
Marshall,
Horwitz,
Nikolopoulos,
Douglass,
Bagrodia,
Brown,
Scott,
Somlyo,
Perrotta,
Leopardi,
Konicek,
Settleman,
Printup,
- Modulation of myosin light-chain phosphorylation by p21-activated kinase 1 in Escherichia coli invasion of human brain microvascular endothelial cells. Rudrabhatla, R.S., Sukumaran, S.K., Bokoch, G.M., Prasadarao, N.V. Infect. Immun. (2003)
- A clue to the therapy of neurofibromatosis type 2: NF2/merlin is a PAK1 inhibitor. Hirokawa, Y., Tikoo, A., Huynh, J., Utermark, T., Hanemann, C.O., Giovannini, M., Xiao, G.H., Testa, J.R., Wood, J., Maruta, H. Cancer journal (Sudbury, Mass.) (2004)
- Increased p21-activated kinase-1 expression is associated with invasive potential in uveal melanoma. Pavey, S., Zuidervaart, W., van Nieuwpoort, F., Packer, L., Jager, M., Gruis, N., Hayward, N. Melanoma Res. (2006)
- Signal therapy of human pancreatic cancer and NF1-deficient breast cancer xenograft in mice by a combination of PP1 and GL-2003, anti-PAK1 drugs (Tyr-kinase inhibitors). Hirokawa, Y., Levitzki, A., Lessene, G., Baell, J., Xiao, Y., Zhu, H., Maruta, H. Cancer Lett. (2007)
- Central Nervous System Functions of PAK Protein Family: From Spine Morphogenesis to Mental Retardation. Boda, B., Nikonenko, I., Alberi, S., Muller, D. Mol. Neurobiol. (2006)
- Biology of the p21-activated kinases. Bokoch, G.M. Annu. Rev. Biochem. (2003)
- Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase. Somlyo, A.P., Somlyo, A.V. Physiol. Rev. (2003)
- A Rac-cGMP Signaling Pathway. Guo, D., Tan, Y.C., Wang, D., Madhusoodanan, K.S., Zheng, Y., Maack, T., Zhang, J.J., Huang, X.Y. Cell (2007)
- PAK-in' Up cGMP for the Move. Settleman, J. Cell (2007)
- Activation of p21-activated kinase 1 is required for lysophosphatidic acid-induced focal adhesion kinase phosphorylation and cell motility in human melanoma A2058 cells. Jung, I.D., Lee, J., Lee, K.B., Park, C.G., Kim, Y.K., Seo, D.W., Park, D., Lee, H.W., Han, J.W., Lee, H.Y. Eur. J. Biochem. (2004)
- Nuclear p21-activated kinase 1 in breast cancer packs off tamoxifen sensitivity. Rayala, S.K., Molli, P.R., Kumar, R. Cancer Res. (2006)
- Inhibition of myosin light chain kinase by p21-activated kinase. Sanders, L.C., Matsumura, F., Bokoch, G.M., de Lanerolle, P. Science (1999)
- AILIM/ICOS-mediated elongation of activated T cells is regulated by both the PI3-kinase/Akt and Rho family cascade. Nukada, Y., Okamoto, N., Konakahara, S., Tezuka, K., Ohashi, K., Mizuno, K., Tsuji, T. Int. Immunol. (2006)
- PAK1 regulates myosin II-B phosphorylation, filament assembly, localization and cell chemotaxis. Even-Faitelson, L., Rosenberg, M., Ravid, S. Cell. Signal. (2005)
- Identification of dynein light chain 2 as an interaction partner of p21-activated kinase 1. Lu, J., Sun, Q., Chen, X., Wang, H., Hu, Y., Gu, J. Biochem. Biophys. Res. Commun. (2005)
- The active conformation of the PAK1 kinase domain. Lei, M., Robinson, M.A., Harrison, S.C. Structure (Camb.) (2005)
- PAK1 hyperactivation is sufficient for mammary gland tumor formation. Wang, R.A., Zhang, H., Balasenthil, S., Medina, D., Kumar, R. Oncogene (2006)
- Paxillin-dependent paxillin kinase linker and p21-activated kinase localization to focal adhesions involves a multistep activation pathway. Brown, M.C., West, K.A., Turner, C.E. Mol. Biol. Cell (2002)
- Critical Role of Vimentin Phosphorylation at Ser-56 by p21-activated Kinase in Vimentin Cytoskeleton Signaling. Li, Q.F., Spinelli, A.M., Wang, R., Anfinogenova, Y., Singer, H.A., Tang, D.D. J. Biol. Chem. (2006)
- Identification of a putative effector for Cdc42Hs with high sequence similarity to the RasGAP-related protein IQGAP1 and a Cdc42Hs binding partner with similarity to IQGAP2. McCallum, S.J., Wu, W.J., Cerione, R.A. J. Biol. Chem. (1996)
- The epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 (Iressa) suppresses c-Src and Pak1 pathways and invasiveness of human cancer cells. Yang, Z., Bagheri-Yarmand, R., Wang, R.A., Adam, L., Papadimitrakopoulou, V.V., Clayman, G.L., El-Naggar, A., Lotan, R., Barnes, C.J., Hong, W.K., Kumar, R. Clin. Cancer Res. (2004)
- Amplification of CCND1 and PAK1 as predictors of recurrence and tamoxifen resistance in postmenopausal breast cancer. Bostner, J., Ahnström Waltersson, M., Fornander, T., Skoog, L., Nordenskjöld, B., Stål, O. Oncogene (2007)
- alpha6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-kappaB-dependent resistance to apoptosis in 3D mammary acini. Friedland, J.C., Lakins, J.N., Kazanietz, M.G., Chernoff, J., Boettiger, D., Weaver, V.M. J. Cell. Sci. (2007)
- p21-activated kinase 1 is activated through the mammalian target of rapamycin/p70 S6 kinase pathway and regulates the replication of hepatitis C virus in human hepatoma cells. Ishida, H., Li, K., Yi, M., Lemon, S.M. J. Biol. Chem. (2007)
- Involvement of alpha-PAK-interacting exchange factor in the PAK1-c-Jun NH(2)-terminal kinase 1 activation and apoptosis induced by benzo[a]pyrene. Yoshii, S., Tanaka, M., Otsuki, Y., Fujiyama, T., Kataoka, H., Arai, H., Hanai, H., Sugimura, H. Mol. Cell. Biol. (2001)
- Androgen receptor specifically interacts with a novel p21-activated kinase, PAK6. Yang, F., Li, X., Sharma, M., Zarnegar, M., Lim, B., Sun, Z. J. Biol. Chem. (2001)
- Regulation of actin polymerization in cell-free systems by GTPgammaS and Cdc42. Zigmond, S.H., Joyce, M., Borleis, J., Bokoch, G.M., Devreotes, P.N. J. Cell Biol. (1997)
- Phosphorylation of RhoGDI by p21-activated kinase 1. DerMardirossian, C.M., Bokoch, G.M. Meth. Enzymol. (2006)
- Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling. Turner, C.E., Brown, M.C., Perrotta, J.A., Riedy, M.C., Nikolopoulos, S.N., McDonald, A.R., Bagrodia, S., Thomas, S., Leventhal, P.S. J. Cell Biol. (1999)
- p21-activated kinase 1 interacts with and phosphorylates histone H3 in breast cancer cells. Li, F., Adam, L., Vadlamudi, R.K., Zhou, H., Sen, S., Chernoff, J., Mandal, M., Kumar, R. EMBO Rep. (2002)
- Phosphorylation of the NF2 tumor suppressor in Schwann cells is mediated by Cdc42-Pak and requires paxillin binding. Thaxton, C., Lopera, J., Bott, M., Baldwin, M.E., Kalidas, P., Fernandez-Valle, C. Mol. Cell. Neurosci. (2007)
- Phosphorylation of serine 709 in GIT1 regulates protrusive activity in cells. Webb, D.J., Kovalenko, M., Whitmore, L., Horwitz, A.F. Biochem. Biophys. Res. Commun. (2006)
- p21-activated kinase (Pak) regulates NADPH oxidase activation in human neutrophils. Martyn, K.D., Kim, M.J., Quinn, M.T., Dinauer, M.C., Knaus, U.G. Blood (2005)
- Signaling through Raf-1 in the neovasculature and target validation by nanoparticles. Wary, K.K. Mol. Cancer (2003)
- Cell surface heparan sulfate participates in CXCL1-induced signaling. Wang, D., Sai, J., Richmond, A. Biochemistry (2003)
- The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family. Koh, C.G., Tan, E.J., Manser, E., Lim, L. Curr. Biol. (2002)
- Phosphorylation of Raf-1 by p21-activated kinase 1 and Src regulates Raf-1 autoinhibition. Tran, N.H., Frost, J.A. J. Biol. Chem. (2003)
- A p21-activated kinase-controlled metabolic switch up-regulates phagocyte NADPH oxidase. Shalom-Barak, T., Knaus, U.G. J. Biol. Chem. (2002)
- Structural requirements for PAK activation by Rac GTPases. Knaus, U.G., Wang, Y., Reilly, A.M., Warnock, D., Jackson, J.H. J. Biol. Chem. (1998)
- Vascular endothelial growth factor up-regulation via p21-activated kinase-1 signaling regulates heregulin-beta1-mediated angiogenesis. Bagheri-Yarmand, R., Vadlamudi, R.K., Wang, R.A., Mendelsohn, J., Kumar, R. J. Biol. Chem. (2000)
- PAK1 primes MEK1 for phosphorylation by Raf-1 kinase during cross-cascade activation of the ERK pathway. Coles, L.C., Shaw, P.E. Oncogene (2002)
- Lim kinase regulates the development of olfactory and neuromuscular synapses. Ang, L.H., Chen, W., Yao, Y., Ozawa, R., Tao, E., Yonekura, J., Uemura, T., Keshishian, H., Hing, H. Dev. Biol. (2006)
- Filopodia are conduits for melanosome transfer to keratinocytes. Scott, G., Leopardi, S., Printup, S., Madden, B.C. J. Cell. Sci. (2002)
- Pak-1 expression increases with progression of colorectal carcinomas to metastasis. Carter, J.H., Douglass, L.E., Deddens, J.A., Colligan, B.M., Bhatt, T.R., Pemberton, J.O., Konicek, S., Hom, J., Marshall, M., Graff, J.R. Clin. Cancer Res. (2004)
- A method to measure the interaction of Rac/Cdc42 with their binding partners using fluorescence resonance energy transfer between mutants of green fluorescent protein. Graham, D.L., Lowe, P.N., Chalk, P.A. Anal. Biochem. (2001)
- Basic fibroblast growth factor-induced translocation of p21-activated kinase to the membrane is independent of phospholipase C-gamma1 in the differentiation of PC12 cells. Shin, K.S., Shin, E.Y., Lee, C.S., Quan, S.H., Woo, K.N., Soung, N.K., Kwak, S.J., Kim, S.R., Kim, E.G. Exp. Mol. Med. (2002)