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Gene Review

GINS1  -  GINS complex subunit 1 (Psf1 homolog)

Homo sapiens

Synonyms: DNA replication complex GINS protein PSF1, GINS complex subunit 1, KIAA0186, PSF1
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Disease relevance of GINS1


High impact information on GINS1


Analytical, diagnostic and therapeutic context of GINS1

  • Here we used the gene-targeting technique to determine the physiological function of PSF1 in vivo [2].


  1. The human GINS complex binds to and specifically stimulates human DNA polymerase alpha-primase. De Falco, M., Ferrari, E., De Felice, M., Rossi, M., H??bscher, U., Pisani, F.M. EMBO Rep. (2007) [Pubmed]
  2. PSF1 is essential for early embryogenesis in mice. Ueno, M., Itoh, M., Kong, L., Sugihara, K., Asano, M., Takakura, N. Mol. Cell. Biol. (2005) [Pubmed]
  3. Porcine steroidogenic factor-1 gene (pSF-1) expression and analysis of embryonic pig gonads during sexual differentiation. Pilon, N., Behdjani, R., Daneau, I., Lussier, J.G., Silversides, D.W. Endocrinology (1998) [Pubmed]
  4. Insulin stimulates a novel GTPase activity in human platelets. Gawler, D., Houslay, M.D. FEBS Lett. (1987) [Pubmed]
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