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MeSH Review

Sex Differentiation

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Disease relevance of Sex Differentiation


Psychiatry related information on Sex Differentiation

  • Administration of testosterone propionate (TP) to castrated (neonatally) males during a critical period (days 6-13) imprinted for the subsequent sex differentiation of HCLA sites, whereas TP administration at other times did not [4].

High impact information on Sex Differentiation


Chemical compound and disease context of Sex Differentiation


Biological context of Sex Differentiation


Anatomical context of Sex Differentiation


Associations of Sex Differentiation with chemical compounds


Gene context of Sex Differentiation


Analytical, diagnostic and therapeutic context of Sex Differentiation


  1. Normal prenatal but arrested postnatal sexual development of luteinizing hormone receptor knockout (LuRKO) mice. Zhang, F.P., Poutanen, M., Wilbertz, J., Huhtaniemi, I. Mol. Endocrinol. (2001) [Pubmed]
  2. An enzyme linked immunoassay for anti-müllerian hormone: a new tool for the evaluation of testicular function in infants and children. Josso, N., Legeai, L., Forest, M.G., Chaussain, J.L., Brauner, R. J. Clin. Endocrinol. Metab. (1990) [Pubmed]
  3. Molecular analysis of the sex-determining region from the Y chromosome in two patients with Frasier syndrome. Berta, P., Morin, D., Poulat, F., Taviaux, S., Lobaccaro, J.M., Sultan, C., Dumas, R. Horm. Res. (1992) [Pubmed]
  4. Imprinting of hepatic estrogen-binding proteins by neonatal androgens. Sloop, T.C., Clark, J.C., Rumbaugh, R.C., Lucier, G.W. Endocrinology (1983) [Pubmed]
  5. Separation of the genetic loci for the H-Y antigen and for testis determination on human Y chromosome. Simpson, E., Chandler, P., Goulmy, E., Disteche, C.M., Ferguson-Smith, M.A., Page, D.C. Nature (1987) [Pubmed]
  6. Endogenous expression of Müllerian inhibiting substance in early postnatal rat sertoli cells requires multiple steroidogenic factor-1 and GATA-4-binding sites. Watanabe, K., Clarke, T.R., Lane, A.H., Wang, X., Donahoe, P.K. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  7. Anti-Müllerian hormone produces endocrine sex reversal of fetal ovaries. Vigier, B., Forest, M.G., Eychenne, B., Bézard, J., Garrigou, O., Robel, P., Josso, N. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  8. The Lutheran and secretor loci: genetic linkage analysis. Lewis, M., Kaita, H., Chown, B., Giblett, E.R., Anderson, J., Côté, G.B. Am. J. Hum. Genet. (1977) [Pubmed]
  9. Structural and functional characterization of the mouse Sox9 promoter: implications for campomelic dysplasia. Kanai, Y., Koopman, P. Hum. Mol. Genet. (1999) [Pubmed]
  10. Effects of styrene monomer and trimer on gonadal sex differentiation of genetic males of the frog Rana rugosa. Ohtani, H., Ichikawa, Y., Iwamoto, E., Miura, I. Environmental research. (2001) [Pubmed]
  11. Zfx mutation results in small animal size and reduced germ cell number in male and female mice. Luoh, S.W., Bain, P.A., Polakiewicz, R.D., Goodheart, M.L., Gardner, H., Jaenisch, R., Page, D.C. Development (1997) [Pubmed]
  12. The molecular mechanisms of coactivator utilization in ligand-dependent transactivation by the androgen receptor. Estébanez-Perpiñá, E., Moore, J.M., Mar, E., Delgado-Rodrigues, E., Nguyen, P., Baxter, J.D., Buehrer, B.M., Webb, P., Fletterick, R.J., Guy, R.K. J. Biol. Chem. (2005) [Pubmed]
  13. Functional characterization of naturally occurring mutant androgen receptors from subjects with complete androgen insensitivity. Brown, T.R., Lubahn, D.B., Wilson, E.M., French, F.S., Migeon, C.J., Corden, J.L. Mol. Endocrinol. (1990) [Pubmed]
  14. ATRX and sex differentiation. Tang, P., Park, D.J., Marshall Graves, J.A., Harley, V.R. Trends Endocrinol. Metab. (2004) [Pubmed]
  15. Ad4BP/SF-1, a transcription factor essential for the transcription of steroidogenic cytochrome P450 genes and for the establishment of the reproductive function. Morohashi, K.I., Omura, T. FASEB J. (1996) [Pubmed]
  16. Cloning, expression, and alternative splicing of the receptor for anti-Müllerian hormone. di Clemente, N., Wilson, C., Faure, E., Boussin, L., Carmillo, P., Tizard, R., Picard, J.Y., Vigier, B., Josso, N., Cate, R. Mol. Endocrinol. (1994) [Pubmed]
  17. Identification of two teleost homologs of the Drosophila sex determination factor, transformer-2 in medaka (Oryzias latipes). Shiraishi, E., Imazato, H., Yamamoto, T., Yokoi, H., Abe, S., Kitano, T. Mech. Dev. (2004) [Pubmed]
  18. AMH and AMH receptor defects in persistent Müllerian duct syndrome. Josso, N., Belville, C., di Clemente, N., Picard, J.Y. Hum. Reprod. Update (2005) [Pubmed]
  19. Sexually dimorphic expression of a teleost homologue of Müllerian inhibiting substance during gonadal sex differentiation in Japanese flounder, Paralichthys olivaceus. Yoshinaga, N., Shiraishi, E., Yamamoto, T., Iguchi, T., Abe, S., Kitano, T. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  20. Phenotypic variation in a family with partial androgen insensitivity syndrome explained by differences in 5alpha dihydrotestosterone availability. Boehmer, A.L., Brinkmann, A.O., Nijman, R.M., Verleun-Mooijman, M.C., de Ruiter, P., Niermeijer, M.F., Drop, S.L. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  21. Micropenis and the 5alpha-reductase-2 (SRD5A2) gene: mutation and V89L polymorphism analysis in 81 Japanese patients. Sasaki, G., Ogata, T., Ishii, T., Kosaki, K., Sato, S., Homma, K., Takahashi, T., Hasegawa, T., Matsuo, N. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  22. Association between plasma level of growth hormone and sex differentiation of hepatic steroid metabolism in the rat. Mode, A., Gustafsson, J.A., Jansson, J.O., Edén, S., Isaksson, O. Endocrinology (1982) [Pubmed]
  23. Minireview: sex differentiation. Hughes, I.A. Endocrinology (2001) [Pubmed]
  24. Cerebral and gonadal aromatase expressions are differently affected during sex differentiation of Pleurodeles waltl. Kuntz, S., Chesnel, A., Flament, S., Chardard, D. J. Mol. Endocrinol. (2004) [Pubmed]
  25. Expression of MIS in the testis is downregulated by tumor necrosis factor alpha through the negative regulation of SF-1 transactivation by NF-kappa B. Hong, C.Y., Park, J.H., Seo, K.H., Kim, J.M., Im, S.Y., Lee, J.W., Choi, H.S., Lee, K. Mol. Cell. Biol. (2003) [Pubmed]
  26. Conservation of the function of DMRT1 regulatory sequences in mammalian sex differentiation. Boyer, A., Dornan, S., Daneau, I., Lussier, J., Silversides, D.W. Genesis (2002) [Pubmed]
  27. Pod-1/Capsulin shows a sex- and stage-dependent expression pattern in the mouse gonad development and represses expression of Ad4BP/SF-1. Tamura, M., Kanno, Y., Chuma, S., Saito, T., Nakatsuji, N. Mech. Dev. (2001) [Pubmed]
  28. Sox8 is expressed at similar levels in gonads of both sexes during the sex determining period in turtles. Takada, S., DiNapoli, L., Capel, B., Koopman, P. Dev. Dyn. (2004) [Pubmed]
  29. Involvement of estrogens in the process of sex differentiation in two fish species: the rainbow trout (Oncorhynchus mykiss) and a tilapia (Oreochromis niloticus). Guiguen, Y., Baroiller, J.F., Ricordel, M.J., Iseki, K., Mcmeel, O.M., Martin, S.A., Fostier, A. Mol. Reprod. Dev. (1999) [Pubmed]
  30. Ontogeny and distribution of gonadotropin-releasing hormone (GnRH) neuronal systems in the brain of the cichlid fish Cichlasoma dimerus. Pandolfi, M., Parhar, I.S., Ravaglia, M.A., Meijide, F.J., Maggese, M.C., Paz, D.A. Anat. Embryol. (2002) [Pubmed]
  31. Estradiol-17beta content in developing eggs and induced sex reversal of the medaka (Oryzias latipes). Iwamatsu, T., Kobayashi, H., Hamaguchi, S., Sagegami, R., Shuo, T. J. Exp. Zoolog. Part A Comp. Exp. Biol. (2005) [Pubmed]
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